Liposomal Nattokinase Case Study | Codeage Education
The Longevity Code · Pillar 04 · Systemic Balance
Education · Nattokinase

Liposomal Nattokinase
A centuries-old fermentation tradition.
Liposomal delivery.

200mg of nattokinase per capsule — an enzyme derived from natto, a traditional Japanese fermented soybean food — delivered through the Codeage Helix Liposomal system.

200mg
Nattokinase Per Capsule
4,000FU
Fibrinolytic Units
Helix
Liposomal Delivery
7 min read·Systemic Balance·Liposomal Capsule
Pillar Overview
04
Systemic Balance
The Longevity Code

An enzyme born from fermentation. A tradition that spans centuries in Japanese food culture.

Nattokinase is an enzyme originally identified in nattō — a traditional Japanese food made from soybeans fermented with Bacillus subtilis var. natto. Nattō has been consumed in Japan for centuries as a staple food, and nattokinase was first described in the published scientific literature in the 1980s as the fibrinolytic enzyme present in this fermented food.

Codeage Liposomal Nattokinase delivers 200mg of nattokinase (4,000 FU) per capsule using the Codeage Helix Liposomal system with phospholipids from non-GMO sunflower lecithin. The capsule is methylcellulose — a plant-derived material. Pillar 04 of The Longevity Code is focused on systemic balance — supporting the body's interconnected systems.

The Enzyme

Nattokinase. From fermented soybeans to published research.

Nattokinase is a serine protease enzyme produced during the fermentation of soybeans into nattō. It was first isolated and described by Dr. Hiroyuki Sumi in 1987, and has since become the subject of a growing body of published scientific literature.

Enzyme Activity Visualization · Illustrative
NK
The Enzyme

Nattokinase

A serine protease enzyme derived from nattō — a traditional Japanese fermented soybean food. Nattokinase has been the subject of published research since the late 1980s and is one of the most recognized enzymes originating from a fermented food source.

FU
The Measurement

4,000 Fibrinolytic Units

Nattokinase activity is measured in fibrinolytic units (FU) — a standardized unit used to quantify its enzymatic activity. This formula delivers 4,000 FU per capsule, as stated on the supplement facts panel.

The Delivery

Helix Liposomal

Delivered through the Codeage Helix Liposomal system using phospholipids from non-GMO sunflower lecithin, including phosphatidylcholine. A deliberate formulation choice for this enzyme.

Nattō. A fermentation tradition rooted in Japanese food culture.

Nattō is a traditional Japanese food produced by fermenting soybeans with the bacterium Bacillus subtilis var. natto. It has been consumed in Japan for centuries and remains a common part of the Japanese diet today. The characteristic stringy texture of nattō is a result of the fermentation process — and it is this process that produces the enzyme nattokinase.

Nattō · Traditional Fermented Food

Centuries of tradition. A single enzyme isolated from it.

The enzyme nattokinase was first identified and isolated from nattō by Japanese researcher Dr. Hiroyuki Sumi in 1987. While nattō itself has been part of Japanese food culture for centuries, the scientific characterization of nattokinase as a distinct enzyme is a more recent development — and one that has led to a growing body of published research examining this enzyme in various contexts.

Nattokinase Per Capsule
4,000
FU · Fibrinolytic Units
200mg Nattokinase · Helix Liposomal Delivery

200mg of nattokinase per capsule delivering 4,000 fibrinolytic units — through the Codeage Helix Liposomal system with phospholipids from non-GMO sunflower lecithin. In a methylcellulose capsule.

Codeage Helix. Liposomal from sunflower lecithin.

The Codeage Helix Liposomal Delivery system provides phospholipids from non-GMO sunflower lecithin, including phosphatidylcholine. Liposomal delivery is a format that has been a subject of growing interest in nutritional science research — and its application here reflects a deliberate formulation choice for how this enzyme is delivered.

Codeage Helix · Liposomal System

Phospholipid delivery. Non-GMO sunflower lecithin.

The liposomal format uses phospholipids — molecules with both water-soluble and fat-soluble regions — to deliver the nattokinase. The phospholipids in this formula are sourced from non-GMO sunflower lecithin. This is the same Helix Liposomal system used across the Codeage liposomal product line — applied here to an enzyme derived from a centuries-old fermentation tradition.

Helix
Liposomal
Codeage Helix · Liposomal Platform

The same liposomal system. Applied to nattokinase.

The Codeage Helix Liposomal Delivery system is a proprietary platform using phospholipids from non-GMO sunflower lecithin, including phosphatidylcholine. It is the same liposomal system found across the Codeage liposomal product line — a platform-level formulation technology applied here to nattokinase in capsule form.

What the literature has explored.

Three areas of published research relevant to the enzyme in this formula — shared as educational context only.

Published Research Reference · Discovery of Nattokinase
"Nattokinase was first identified and characterized by Dr. Hiroyuki Sumi in 1987 as a fibrinolytic enzyme produced during the fermentation of soybeans into nattō. Published research has since examined this enzyme in various contexts, establishing it as one of the most studied enzymes derived from a traditional fermented food."
For reference: Sumi, H., et al. (1987). A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia, 43(10), 1110–1111
Published Research Reference · Nattokinase as an Enzyme
"Nattokinase is classified as a serine protease — a category of enzymes characterized by a specific catalytic mechanism. Published research has examined its enzymatic properties, its production through Bacillus subtilis fermentation, and its measurement in fibrinolytic units (FU) as a standardized activity metric."
For reference: Chen, H., et al. (2018). Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomarker Insights, 13
Published Research Reference · Nattō in the Japanese Diet
"Nattō has been consumed in Japan for centuries as a traditional fermented soybean food. Published research has examined its nutritional composition and its role in the traditional Japanese diet, where it remains a widely consumed food to this day."
For reference: Weng, Y., et al. (2017). Nattokinase: An Oral Antithrombotic Agent. Journal of Atherosclerosis and Thrombosis, 24(5), 490–500

The studies referenced above were conducted independently and did not involve this product. They are cited here solely for educational context regarding the enzyme discussed, and do not represent claims about the intended effects of this formula.

An enzyme with a growing body of published research.

Since its initial characterization in 1987, nattokinase has become the subject of a growing number of published studies. The following areas represent key themes in the published literature — shared here as educational context.

Fermentation Origin

Nattokinase is produced naturally during the bacterial fermentation of soybeans by Bacillus subtilis var. natto. The fermentation process itself is central to the enzyme's production.

Serine Protease

Nattokinase is classified as a serine protease — a type of enzyme that uses a serine residue in its catalytic mechanism. This is a well-characterized category of enzymes in biochemistry.

Fibrinolytic Units

The enzymatic activity of nattokinase is measured in fibrinolytic units (FU) — a standardized measurement used to quantify the activity level of this specific enzyme.

Published Since 1987

Nattokinase was first described in the published literature in 1987 by Dr. Hiroyuki Sumi. Since then, the enzyme has been the subject of a growing body of scientific publications.

From Nattō

The name "nattokinase" comes directly from "nattō" — the traditional Japanese fermented soybean food from which it was first isolated. The enzyme name reflects its origin.

The format is a formulation decision.

Delivering 200mg of nattokinase (4,000 FU) through the Codeage Helix Liposomal system in a methylcellulose capsule reflects the considerations of enzyme delivery, dosing, and suitability for daily use.

200mg
Nattokinase Per Capsule

200mg per capsule. 4,000 FU.

200mg of nattokinase delivering 4,000 fibrinolytic units per capsule. The serving size is one capsule — a single-capsule serving for daily use.

4K
Fibrinolytic Units

Standardized activity measurement.

Nattokinase activity is measured in FU — fibrinolytic units. This formula delivers 4,000 FU per capsule, as indicated on the supplement facts panel.

Helix Liposomal System

Phospholipid delivery.

The Codeage Helix Liposomal system uses phospholipids from non-GMO sunflower lecithin, including phosphatidylcholine — a liposomal delivery method applied to this enzyme.

⦿
Methylcellulose Capsule

Plant-based. Vegan-friendly.

The capsule shell is methylcellulose — a plant-derived material. Compatible with a broad range of dietary preferences. Contains soy, as indicated on the product label.

The Longevity Code · Architecture

Systemic balance.
Rooted in a centuries-old tradition.

Pillar 04 of The Longevity Code is focused on systemic balance — supporting the body's interconnected systems. Nattokinase — an enzyme born from Japanese fermentation tradition — delivered through the Helix Liposomal system.

01 · Daily Foundation 02 · Structural Integrity 03 · Cellular Longevity 04 · Systemic Balance

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