Medicinal Ingredients (per capsules): Hydrolyzed collagen (Chicken cartilage) 283 mg, Hydrolyzed collagen (Bos - Bovine skin/hide split) 283 mg, Withania somnifera, Ashwagandha (Root) 34.6 mg, Curcuma longa, Turmeric (Rhizome) 33 mg, Phyllanthus emblica, Amla (Fruit) 33 mg. Non-Medicinal Ingredients: Methylcellulose capsule.

Contains 8 of 9 essential amino acids. Not a significant source of protein. Collagen protein does not count toward the FDA recommended Percent Daily Value for protein because it lacks one essential amino acid: tryptophan.

Adults take 3 capsules 2 times per day. Take up to 6 capsules each day in divided doses. Take 2 hours before or after taking other medications. May be taken with or without food.

CAUTION: Keep out of the reach of children. Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended. If you have gallstones or a bile duct obstruction, consult a health care practitioner prior to use. If you have stomach ulcers or excess stomach acid, consult a health care practitioner prior to use. If you have or develop abdominal pain, nausea, fever or vomiting, consult a health care practitioner. Known Adverse Reactions: May cause gastrointestinal disturbances in which case, discontinue use. Precautions for Use: Store in a cool, dry place. Do not use if product has been opened or tampered with in any way.

Organic Chicken Bone Broth

Crowley DC, Lau FC, Sharma P, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009;6(6):312‐321. Published 2009 Oct 9. doi: 10.7150/ijms.6.312

Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016;48(2):95‐101. doi: 10.5152/eurasianjmed.2015.15030

Lugo, J.P., Saiyed, Z.M. & Lane, N.E. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J 15, 14 (2015). DOI: 10.1186/s12937-016-0130-8

Bagchi, D., Misner, B., Bagchi, M., Kothari, S. C., Downs, B. W., Fafard, R. D., & Preuss, H. G. (2002). Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. International journal of clinical pharmacology research, 22(3-4), 101–110.

Zhu, P., Li, X. Y., Wang, H. K., Jia, J. F., Zheng, Z. H., Ding, J., & Fan, C. M. (2007). Oral administration of type-II collagen peptide 250-270 suppresses specific cellular and humoral immune response in collagen-induced arthritis. Clinical immunology (Orlando, Fla.), 122(1), 75–84. DOI: 10.1016/j.clim.2006.08.004

Barnett, M. L., Kremer, J. M., St Clair, E. W., Clegg, D. O., Furst, D., Weisman, M., Fletcher, M. J., Chasan-Taber, S., Finger, E., Morales, A., Le, C. H., & Trentham, D. E. (1998). Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis and rheumatism, 41(2), 290–297. DOI: 10.1002/1529-0131(199802)41:2<290::AID-ART13>3.0.CO;2-R

Yoshinari, O., Moriyama, H., & Shiojima, Y. (2015). An overview of a novel, water-soluble undenatured type II collagen (NEXT-II). Journal of the American College of Nutrition, 34(3), 255–262. DOI: 10.1080/07315724.2014.919541

Paul, C., Leser, S., & Oesser, S. (2019). Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance. Nutrients, 11(5), 1079. DOI: 10.3390/nu11051079

Darling, A. L., Manders, R., Sahni, S., Zhu, K., Hewitt, C. E., Prince, R. L., Millward, D. J., & Lanham-New, S. A. (2019). Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 30(4), 741–761. DOI: 10.1007/s00198-019-04933-8

Lerman, R. H., Chang, J. L., Konda, V., Desai, A., & Montalto, M. B. (2015). Nutritional Approach for Relief of Joint Discomfort: A 12-week, Open-case Series and Illustrative Case Report. Integrative medicine (Encinitas, Calif.), 14(5), 52–61. PMCID: PMC4712866

Organic Bovine Bone Broth

Vollmer DL, West VA, Lephart ED. Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome. Int J Mol Sci. 2018;19(10):3059. Published 2018 Oct 7. doi: 10.3390/ijms19103059

Saha A, Alam MJ, Ashraf KU, Mannan A. Computational analysis of bovine alpha-1 collagen sequences. Bioinformation. 2013;9(1):42‐48. doi: 10.6026/97320630009042

León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed Collagen-Sources and Applications. Molecules. 2019;24(22):4031. Published 2019 Nov 7. doi: 10.3390/molecules24224031

K. Henriksen, M.A. Karsdal, in Biochemistry of Collagens, Laminins and Elastin, 2016

Albaugh VL, Mukherjee K, Barbul A. Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing. J Nutr. 2017;147(11):2011‐2017. doi:10.3945/jn.117.256404

Avila Rodríguez, MI, Rodríguez Barroso, LG, Sánchez, ML. Collagen: A review on its sources and potential cosmetic applications. J Cosmet. Dermatol. 2018; 17: 20– 26. DOI: 10.1111/jocd.12450

Paul C, Leser S, Oesser S. Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance. Nutrients. 2019;11(5):1079. Published 2019 May 15.  doi: 10.3945/jn.117.256404

Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2014). Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin pharmacology and physiology, 27(1), 47–55. DOI: 10.1159/000351376

Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015;114(8):1237‐1245. doi: 10.1017/S0007114515002810

Organic Ashwagandha

Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255–262. doi: 10.4103/0253-7176.106022

BHATIA, V. and TANDON, R.K. (2005), Stress and the gastrointestinal tract. Journal of Gastroenterology and Hepatology, 20: 332-339. doi:10.1111/j.1440-1746.2004.03508.x

Singh SK, Rajoria K. Ayurvedic management of chronic constipation in Hirschsprung disease - A case study. J Ayurveda Integr Med. 2018;9(2):131–135. doi: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033722/

Mishra, L.C. & Singh, B.B. & Dagenais, Simon. (2000). Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): A Review. Alternative medicine review : a journal of clinical therapeutic. 5. 334-46. https://www.researchgate.net/publication/12365397_Scientific_basis_for_the_therapeutic_use_of_Withania_somnifera_Ashwagandha_A_Review

Organic Turmeric Extract

Hewlings SJ, Kalman DS. Curcumin: A Review of Its' Effects on Human Health. Foods. 2017;6(10):92. Published 2017 Oct 22. doi.org/10.3390/foods6100092.

Langhans, Sigrid. (2011). Therapeutic potential of curcumin in gastrointestinal diseases. World journal of gastrointestinal pathophysiology. 2. 1-14. DOI: 10.4291/wjgp.v2.i1.1

Adrian L Lopresti, The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects?, Advances in Nutrition, Volume 9, Issue 1, January 2018, Pages 41–50, https://doi.org/10.1093/advances/nmx011

Chainani-Wu N. (2003). Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). Journal of alternative and complementary medicine (New York, N.Y.), 9(1), 161–168. DOI: 10.1089/107555303321223035

Zdrojewicz, Z., Szyca, M., Popowicz, E., Michalik, T., & Śmieszniak, B. (2017). Kurkuma – nie tylko przyprawa [Turmeric - not only spice]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 42(252), 227–230. PMID: 28662006

Gupta, S. C., Sung, B., Kim, J. H., Prasad, S., Li, S., & Aggarwal, B. B. (2013). Multitargeting by turmeric, the golden spice: From kitchen to clinic. Molecular nutrition & food research, 57(9), 1510–1528. DOI: 10.1002/mnfr.201100741

Organic Alma Berry Extract

Baliga, M. S., & Dsouza, J. J. (2011). Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 20(3), 225–239. DOI: 10.1097/CEJ.0b013e32834473f4

Scartezzini, P., Antognoni, F., Raggi, M. A., Poli, F., & Sabbioni, C. (2006). Vitamin C content and antioxidant activity of the fruit and of the Ayurvedic preparation of Emblica officinalis Gaertn. Journal of ethnopharmacology, 104(1-2), 113–118. DOI: 10.1016/j.jep.2005.08.065

Fujii, T., Wakaizumi, M., Ikami, T., & Saito, M. (2008). Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts. Journal of ethnopharmacology, 119(1), 53–57. DOI: 10.1016/j.jep.2008.05.039

Chen, T. S., Liou, S. Y., & Chang, Y. L. (2009). Supplementation of Emblica officinalis (Amla) extract reduces oxidative stress in uremic patients. The American journal of Chinese medicine, 37(1), 19–25. DOI: 10.1142/S0192415X09006680

Poltanov, E. A., Shikov, A. N., Dorman, H. J., Pozharitskaya, O. N., Makarov, V. G., Tikhonov, V. P., & Hiltunen, R. (2009). Chemical and antioxidant evaluation of Indian gooseberry (Emblica officinalis Gaertn., syn. Phyllanthus emblica L.) supplements. Phytotherapy research : PTR, 23(9), 1309–1315. DOI: 10.1002/ptr.2775

Chen, T. S., Liou, S. Y., Wu, H. C., Tsai, F. J., Tsai, C. H., Huang, C. Y., & Chang, Y. L. (2011). Efficacy of epigallocatechin-3-gallate and Amla (Emblica officinalis) extract for the treatment of diabetic-uremic patients. Journal of medicinal food, 14(7-8), 718–723. DOI: 10.1089/jmf.2010.1195

Zhao T, Sun Q, Marques M, Witcher M. Anticancer Properties of Phyllanthus emblica (Indian Gooseberry). Oxid Med Cell Longev. 2015;2015:950890. doi: 10.1155/2015/950890