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Multi Collagen Peptides Powder Platinum Stick Pack.

Enfocar Codeage Multi Collagen Platinum Biotin Keratin Vitamin C Sachet Stick Pack
Enfocar Codeage Multi Collagen Vitamin C D3 B6 5 Types collagen hydrolyzed
Enfocar Codeage Multi Collagen Biotin 10000 mcg Stick Sachet Hyaluronic Acid
Enfocar Codeage Multi Collagen Platinum Stick Joint Health Bones Support
Enfocar Codeage Multi Collagen Vitamin C D3 B6
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Enfocar Codeage Multi Collagen Platinum stick packs multi collagen 5 types hydrolyzed peptides grass-fed pasture-raised, 10 000mcg biotin, hyaluronic acid and keratin powder packets
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Multi Collagen Peptides Powder Platinum Stick Pack.

Colágeno, biotina y queratina.

$59.99
Disponible en cómodas barras, la fórmula en polvo premium Codeage Multi Collageno Biotina Platino combina 5 tipos de péptidos de colágeno, 18 aminoácidos, biotina, queratina y vitaminas esenciales B6, C y D3, además de ácido hialurónico y ácido pantoténico. Práctico y todo en uno, cada paquete contiene 30 barras.
  • Los paquetes de barras Codeage Multi Collageno Biotina Platino brindan una manera premium y conveniente de incorporar colágeno en su rutina diaria con una mezcla única de 5 tipos de péptidos de colágeno de 5 fuentes alimenticias diferentes, colágeno alimentado con pasto, colágeno marino capturado en la naturaleza y 18 aminoácidos. todo en uno.
  • Esta fórmula avanzada de colágeno en polvo contiene nutrientes como biotina 10,000 mcg, queratina, vitamina B6, vitamina C, vitamina D3, ácido hialurónico, niacina y ácido pantoténico para ayudar a mantener la salud del cabello, la piel, las uñas, las articulaciones, los huesos y el bienestar general.*
  • Nuestro colágeno proviene de animales criados en pastos y alimentados con pasto, lo que garantiza que sea de la más alta calidad y pureza. Cada caja de suplemento vitamínico y biotina de colágeno múltiple Codeage viene con 30 barras para 1 mes de suministro.
  • Adecuados tanto para mujeres como para hombres, estos paquetes de colágeno en polvo para viaje sin sabor se pueden mezclar fácilmente con sus bebidas frías o calientes, batidos o batidos de proteínas favoritos para aumentar el colágeno en cualquier momento y en cualquier lugar.
  • Fabricado en una instalación certificada por cGMP en los EE. UU., Codeage Multi Collageno Biotina Platino no contiene OGM, no contiene lácteos, no contiene soja, no contiene gluten, no contiene carbohidratos y es adecuado para dietas cetogénicas y paleo. No contiene mariscos, saborizantes, colorantes, edulcorantes, aceites ni conservantes artificiales, lo que lo convierte en una opción de alta calidad para suplementar con colágeno. Esta fórmula también existe en formato bote .
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Disponible en cómodas barras, la fórmula en polvo premium Codeage Multi Collageno Biotina Platino combina 5 tipos de péptidos de colágeno, 18 aminoácidos, biotina, queratina y vitaminas esenciales B6, C y D3, además de ácido hialurónico y ácido pantoténico. Práctico y todo en uno, cada paquete contiene 30 barras.

Información nutricional

Información nutricional

Ingredientes

Vitamina C (como ácido ascórbico), vitamina D3 (como colecalciferol), niacina (como niacinamida), vitamina B6 (como piridoxal-5'-fosfato), biotina, ácido pantoténico (como D-pantotenato de calcio), complejo multicolágeno: Péptidos de colágeno bovino hidrolizado alimentados con pasto (sin EEB), caldo de huesos de pollo, caldo de huesos de res (sin EEB), péptidos de colágeno de pescado hidrolizado capturados en la naturaleza, colágeno de membrana de cáscara de huevo, queratina hidrolizada, ácido hialurónico (como hialuronato de sodio). Contiene: Pescado (Bacalao, Pargo), Huevo.

Perfil de aminoácidos (miligramos promedio por porción): Alanina 867 mg, Arginina 737 mg, Ácido aspártico 558 mg, Ácido glutámico 979 mg, Glicina 2334 mg, Histidina 73 mg, Hidroxilisina 85 mg, Hidroxiprolina 1234 mg, Isoleucina 149 mg, Leucina 285 mg, Lisina 358 mg, Metionina 86 mg, Fenilalanina 189 mg, Prolina 1354 mg, Serina 325 mg, Treonina 177 mg, Tirosina 50 mg, Valina 220 mg. Miligramos promedio por porción de origen natural; los valores absolutos pueden variar. Contiene 8 de 9 aminoácidos esenciales. No es una fuente importante de proteínas. La proteína de colágeno no cuenta para el porcentaje de valor diario de proteína recomendado por la FDA porque carece de un aminoácido esencial: el triptófano. Empaquetado por peso, no por volumen. Puede ocurrir asentamiento.

Product Details

  • Los paquetes de barras Codeage Multi Collageno Biotina Platino brindan una manera premium y conveniente de incorporar colágeno en su rutina diaria con una mezcla única de 5 tipos de péptidos de colágeno de 5 fuentes alimenticias diferentes, colágeno alimentado con pasto, colágeno marino capturado en la naturaleza y 18 aminoácidos. todo en uno.
  • Esta fórmula avanzada de colágeno en polvo contiene nutrientes como biotina 10,000 mcg, queratina, vitamina B6, vitamina C, vitamina D3, ácido hialurónico, niacina y ácido pantoténico para ayudar a mantener la salud del cabello, la piel, las uñas, las articulaciones, los huesos y el bienestar general.*
  • Nuestro colágeno proviene de animales criados en pastos y alimentados con pasto, lo que garantiza que sea de la más alta calidad y pureza. Cada caja de suplemento vitamínico y biotina de colágeno múltiple Codeage viene con 30 barras para 1 mes de suministro.
  • Adecuados tanto para mujeres como para hombres, estos paquetes de colágeno en polvo para viaje sin sabor se pueden mezclar fácilmente con sus bebidas frías o calientes, batidos o batidos de proteínas favoritos para aumentar el colágeno en cualquier momento y en cualquier lugar.
  • Fabricado en una instalación certificada por cGMP en los EE. UU., Codeage Multi Collageno Biotina Platino no contiene OGM, no contiene lácteos, no contiene soja, no contiene gluten, no contiene carbohidratos y es adecuado para dietas cetogénicas y paleo. No contiene mariscos, saborizantes, colorantes, edulcorantes, aceites ni conservantes artificiales, lo que lo convierte en una opción de alta calidad para suplementar con colágeno. Esta fórmula también existe en formato bote .

Supplement Facts

Supplement Facts

Ingredients

Vitamina C (como ácido ascórbico), vitamina D3 (como colecalciferol), niacina (como niacinamida), vitamina B6 (como piridoxal-5'-fosfato), biotina, ácido pantoténico (como D-pantotenato de calcio), complejo multicolágeno: Péptidos de colágeno bovino hidrolizado alimentados con pasto (sin EEB), caldo de huesos de pollo, caldo de huesos de res (sin EEB), péptidos de colágeno de pescado hidrolizado capturados en la naturaleza, colágeno de membrana de cáscara de huevo, queratina hidrolizada, ácido hialurónico (como hialuronato de sodio). Contiene: Pescado (Bacalao, Pargo), Huevo.

Perfil de aminoácidos (miligramos promedio por porción): Alanina 867 mg, Arginina 737 mg, Ácido aspártico 558 mg, Ácido glutámico 979 mg, Glicina 2334 mg, Histidina 73 mg, Hidroxilisina 85 mg, Hidroxiprolina 1234 mg, Isoleucina 149 mg, Leucina 285 mg, Lisina 358 mg, Metionina 86 mg, Fenilalanina 189 mg, Prolina 1354 mg, Serina 325 mg, Treonina 177 mg, Tirosina 50 mg, Valina 220 mg. Miligramos promedio por porción de origen natural; los valores absolutos pueden variar. Contiene 8 de 9 aminoácidos esenciales. No es una fuente importante de proteínas. La proteína de colágeno no cuenta para el porcentaje de valor diario de proteína recomendado por la FDA porque carece de un aminoácido esencial: el triptófano. Empaquetado por peso, no por volumen. Puede ocurrir asentamiento.

Suggested Use

Los adultos mezclan 1 paquete con 8 onzas líquidas de café caliente, líquido caliente o su bebida favorita. ¡Mezcla bien y disfruta!

PRECAUCIÓN: No exceda la dosis recomendada. Tenga cuidado si tiene alergias o sensibilidades a alguno de los ingredientes enumerados. Las madres embarazadas o lactantes y las personas con una afección médica conocida deben consultar a un médico antes de usar este o cualquier suplemento dietético. Utilizar sólo según las indicaciones. Algunas personas pueden experimentar una ligera intolerancia a los productos marinos o bovinos. Si experimenta molestias gastrointestinales (incluyendo hinchazón, calambres, diarrea u otros trastornos digestivos) u otra sensibilidad, deje de tomar el producto inmediatamente. Algunas personas son alérgicas a la carne bovina (carne de res) o al pescado. Si está embarazada, amamantando o tiene una condición médica, consulte con su médico antes de usarlo. Si tiene alguna pregunta sobre el consumo de este suplemento dietético, consulte con su profesional de la salud antes de usarlo. Si usa medicamentos recetados o de venta libre, desconoce su condición médica actual o tiene una condición médica preexistente, consulte con su profesional de la salud antes de usarlos. Suspenda su uso inmediatamente si experimenta algún síntoma o reacción adversa mientras toma este producto. Suspenda su uso 2 semanas antes de la cirugía. No lo use si se desconoce su estado de salud. No lo utilice si el sello de seguridad está dañado o falta. Mantener fuera del alcance de los niños y las mascotas. Conservar en un lugar fresco y seco, alejado de la humedad del calor. La biotina se puede obtener en cantidades adecuadas o adicionales únicamente a través de los alimentos y la dieta habitual. Utilice este producto únicamente como complemento alimenticio. No utilice para la reducción de peso.

References

Biotin: an essential B vitamin involved in a number of specific biological reactions responsible for the metabolism of fats, glucose and amino acids

Biotin. Fact Sheet for Health Professionals.  NIH.  https://ods.od.nih.gov/factsheets/Biotin-HealthProfessional/

Vitamin C: antioxidant support, collagen synthesis, skin & hair health

One of vitamin Cs essential functions is to serve as an antioxidant, protecting the body from excessive oxidation.  Vitamin C plays a pivotal role in the regeneration of vitamin E, another important antioxidant.

Vitamin C.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/

Vitamin C is required to support synthesis of collagen in the body.  Collagen is the major component of the bodys connective tissue.

Vitamin C.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/

Vitamin C supports skin health in two ways: as an antioxidant and as a required cofactor for production of collagen in the body.  References for these roles are provided above.

Skin dermal and epidermal layers contain relatively high amounts of vitamin C.  Age and UV exposure can reduce tissue levels.

Skin Health.  Linus Pauling Institute. Oregon State University. https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-C

Vitamin D, from diet and production within the skin, play a vital role in skin health.  More specifically, vitamin D in skin plays a critical role in regulating the proliferation and differentiation of keratinocytes, the cells responsible for producing the structural protein keratin. This process ensures normal cell growth and maintains the skin barrier. Vitamin D has also been shown to be involved in maintaining the growth cycle of mature hair follicles.

Vitamin D.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/

Vitamin D and Skin Health.  Linus Pauling Institute. Oregon State University.  https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-D

Vitamin B6: essential in the metabolism of protein, fat, carbohydrates

Vitamin B6 is found in 6 forms all of which can be utilized.  Two forms, Pyridoxal 5 phosphate (PLP) and pyridoxamine 5 phosphate (PMP) are the active coenzyme forms of vitamin B6. Vitamin B6 in coenzyme forms performs a wide variety of functions in the body, with involvement in more than 100 enzyme reactions, primarily concerned with protein metabolism. Both PLP and PMP are involved in amino acid metabolism, and PLP is also involved in the metabolism of one-carbon units, carbohydrates, and lipids 

Vitamin B6.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/vitaminb6-healthprofessional/

Pantothenic acid: essential in fatty acid metabolism

The primary functions of Pantothenic acid involve the synthesis of coenzyme A (CoA) and acyl carrier protein, both of which are involved in the metabolism of fatty acids.

Pantothenic acid. Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/

Hydrolyzed keratin protein: a source of amino acids used by the body form new protein

Keratin is a major structural protein in hair and nails.

Composition of hair and nails ( and overview of conditions):

J McKittrick, PY Chen, SG Bodde, W Yang The structure, functions, and mechanical properties of keratin.- Jom, 2012

http://meyersgroup.ucsd.edu/papers/journals/Meyers%20354.pdf

P Grinzi. Hair and nails.  - Australian Family Physician, 2011

https://www.racgp.org.au/getattachment/065396cf-bb0c-4fd6-99fb-63fa5a3770b1/Hair-and-nails.aspx

Hyaluronic acid: joint & skin health

HA supports joint lubrication. Several human studies in persons who are healthy as well as those with osteoarthritis, experienced reduction in knee pain following ingestion of oral HA.  Various daily doses were studied (80 mg-630 mg) and all showed benefit. (The complex molecule hyaluronan is found in the joint space where if lubricates and cushions joints.)

Oe M, Tashiro T, Yoshida H, Nishiyama H, Masuda Y, Maruyama K, Koikeda T, Maruya R, Fukui N. Oral hyaluronan relieves knee pain: a review. Nutr J. 2016 Jan 27;15:11. doi: 10.1186/s12937-016-0128-2. PMID: 26818459; PMCID: PMC4729158.

HA supports skin hydration. Hyaluronic acid is a building block of hyaluronan, a complex molecule found in the extracellular matrix of tissues such as skin, eye and joints.  It plays a role in lubrication of joints and is important in maintaining skin moisture. 

Oral supplementation with HA has been shown in at least 6 human studies to improve skin moisture content.  These studies have been reviewed by Kawada et al.  Studies examined a range of doses (37.5 mg HA per day to 240 mg HA per day-3 studies at 120 mg HA per day). The consumption period ranged from 4 to 12 weeks, with all time periods showing benefit.

Kawada C, Yoshida T, Yoshida H, Matsuoka R, Sakamoto W, Odanaka W, Sato T, Yamasaki T, Kanemitsu T, Masuda Y, Urushibata O. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014 Jul 11;13:70. doi: 10.1186/1475-2891-13-70. PMID: 25014997; PMCID: PMC4110621.

Grass-Fed Hydrolyzed Bovine Collagen

Vollmer DL, West VA, Lephart ED. Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome. Int J Mol Sci. 2018;19(10):3059. Published 2018 Oct 7. doi: 10.3390/ijms19103059

Saha A, Alam MJ, Ashraf KU, Mannan A. Computational analysis of bovine alpha-1 collagen sequences. Bioinformation. 2013;9(1):4248. doi: 10.6026/97320630009042

León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed Collagen-Sources and Applications. Molecules. 2019;24(22):4031. Published 2019 Nov 7. doi: 10.3390/molecules24224031

K. Henriksen, M.A. Karsdal, in Biochemistry of Collagens, Laminins and Elastin, 2016

Albaugh VL, Mukherjee K, Barbul A. Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing. J Nutr. 2017;147(11):20112017. doi:10.3945/jn.117.256404

Avila Rodríguez, MI, Rodríguez Barroso, LG, Sánchez, ML. Collagen: A review on its sources and potential cosmetic applications. J Cosmet. Dermatol. 2018; 17: 20 26. DOI: 10.1111/jocd.12450

Paul C, Leser S, Oesser S. Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance. Nutrients. 2019;11(5):1079. Published 2019 May 15.  doi: 10.3945/jn.117.256404

Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2014). Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin pharmacology and physiology, 27(1), 4755. DOI: 10.1159/000351376

Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015;114(8):12371245. doi: 10.1017/S0007114515002810

Organic Chicken Bone Broth

Crowley DC, Lau FC, Sharma P, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009;6(6):312321. Published 2009 Oct 9. doi: 10.7150/ijms.6.312

Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016;48(2):95101. doi: 10.5152/eurasianjmed.2015.15030

Lugo, J.P., Saiyed, Z.M. & Lane, N.E. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J 15, 14 (2015). DOI: 10.1186/s12937-016-0130-8

Bagchi, D., Misner, B., Bagchi, M., Kothari, S. C., Downs, B. W., Fafard, R. D., & Preuss, H. G. (2002). Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. International journal of clinical pharmacology research, 22(3-4), 101110.

Zhu, P., Li, X. Y., Wang, H. K., Jia, J. F., Zheng, Z. H., Ding, J., & Fan, C. M. (2007). Oral administration of type-II collagen peptide 250-270 suppresses specific cellular and humoral immune response in collagen-induced arthritis. Clinical immunology (Orlando, Fla.), 122(1), 7584. DOI: 10.1016/j.clim.2006.08.004

Barnett, M. L., Kremer, J. M., St Clair, E. W., Clegg, D. O., Furst, D., Weisman, M., Fletcher, M. J., Chasan-Taber, S., Finger, E., Morales, A., Le, C. H., & Trentham, D. E. (1998). Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis and rheumatism, 41(2), 290297. DOI: 10.1002/1529-0131(199802)41:2<290::AID-ART13>3.0.CO;2-R

Yoshinari, O., Moriyama, H., & Shiojima, Y. (2015). An overview of a novel, water-soluble undenatured type II collagen (NEXT-II). Journal of the American College of Nutrition, 34(3), 255262. DOI: 10.1080/07315724.2014.919541

Paul, C., Leser, S., & Oesser, S. (2019). Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance. Nutrients, 11(5), 1079. DOI: 10.3390/nu11051079

Darling, A. L., Manders, R., Sahni, S., Zhu, K., Hewitt, C. E., Prince, R. L., Millward, D. J., & Lanham-New, S. A. (2019). Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 30(4), 741761. DOI: 10.1007/s00198-019-04933-8

Lerman, R. H., Chang, J. L., Konda, V., Desai, A., & Montalto, M. B. (2015). Nutritional Approach for Relief of Joint Discomfort: A 12-week, Open-case Series and Illustrative Case Report. Integrative medicine (Encinitas, Calif.), 14(5), 5261. PMCID: PMC4712866

Biotin

Glynis A. A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2012;5(11):28-34. PMID: 23198010

Janos Zempleni, Yousef I Hassan & Subhashinee SK Wijeratne (2008) Biotin and biotinidase deficiency, Expert Review of Endocrinology & Metabolism, 3:6, 715-724, DOI: 10.1586/17446651.3.6.715

Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166169. doi: 10.1159/000462981

Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166169. doi: 10.1159/000462981

S. Daniells and G. Hardy, Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame? Current Opinion in Clinical Nutrition & Metabolic Care, vol. 13, no. 6, pp. 690697, November 2010. doi: 10.1097/MCO.0b013e32833ece02

Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008;3(6):715724. doi: 10.1586/17446651.3.6.715

2008;3(6):715724. doi: 10.1586/17446651.3.6.715

Sparavigna A, Tenconi B, La Penna L. Efficacy and tolerability of a biomineral formulation for treatment of onychoschizia: a randomized trial. Clin Cosmet Investig Dermatol. 2019;12:355362. Published 2019 May 13. doi: 10.2147/CCID.S187305

Lipner, S. R., & Scher, R. K. (2018). Biotin for the treatment of nail disease: what is the evidence?. The Journal of dermatological treatment, 29(4), 411414. DOI: 10.1080/09546634.2017.1395799

Victor E. Colombo, Françoise Gerber, Max Bronhofer, George L. Floersheim. Treatment of brittle fingernails and onychoschizia with biotin: Scanning electron microscopy. Colombo, Victor E. et al. Journal of the American Academy of Dermatology, Volume 23, Issue 6, 1127 1132. DOI: https://doi.org/10.1016/0190-9622(90)70345-I

Trüeb RM. Serum Biotin Levels in Women Complaining of Hair Loss. Int J Trichology. 2016;8(2):73-77. doi: 10.4103/0974-7753.188040

Floersheim G. L. (1989). Behandlung brüchiger Fingernägel mit Biotin [Treatment of brittle fingernails with biotin]. Zeitschrift fur Hautkrankheiten, 64(1), 4148. PMID: 2648686

Hochman, L. G., Scher, R. K., & Meyerson, M. S. (1993). Brittle nails: response to daily biotin supplementation. Cutis, 51(4), 303305. PMID: 8477615

Scheinfeld, N., Dahdah, M. J., & Scher, R. (2007). Vitamins and minerals: their role in nail health and disease. Journal of drugs in dermatology : JDD, 6(8), 782787. PMID: 17763607

Keratin

Gavazzoni Dias MF. Hair cosmetics: an overview. Int J Trichology. 2015;7(1):215. doi: 10.4103/0974-7753.153450

Bragulla HH, Homberger DG. Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia. J Anat. 2009;214(4):516559. doi: 10.1111/j.1469-7580.2009.01066.x

Basit A, Asghar F, Sadaf S, Akhtar MW. Health improvement of human hair and their reshaping using recombinant keratin K31. Biotechnol Rep (Amst). 2018;20:e00288. Published 2018 Oct 24. doi: 10.1016/j.btre.2018.e00288

Villa, A.L.V., Aragão, M.R.S., dos Santos, E.P. et al. Feather keratin hydrolysates obtained from microbial keratinases: effect on hair fiber. BMC Biotechnol 13, 15 (2013). DOI: 10.1186/1472-6750-13-15

Narda, Mridvika & Aladren, Sonia & Cestone, Enza & Nobile, Vincenzo. (2017). Efficacy and Safety of a Food Supplement Containing L-cystine, Serenoa repens Extract and Biotin for Hair Loss in Healthy Males and Females. A Prospective, Randomized, Double-blinded, Controlled Clinical Trial. Journal of Cosmetology & Trichology. DOI: 10.4172/2471-9323.1000127

Sando, L., Kim, M., Colgrave, M.L., Ramshaw, J.A.M., Werkmeister, J.A. and Elvin, C.M. (2010), Photochemical crosslinking of soluble wool keratins produces a mechanically stable biomaterial that supports cell adhesion and proliferation. J. Biomed. Mater. Res., 95A: 901-911. doi:10.1002/jbm.a.32913

Villa AL, Aragão MR, Dos Santos EP, et al. Feather keratin hydrolysates obtained from microbial keratinases: effect on hair fiber. BMC Biotechnol. 2013;13:15. Published 2013 Feb 18. doi: 10.1186/1472-6750-13-15

Vitamin C & Hyaluronic Acid

Dincel YM, Adanir O, Arikan Y, Caglar AK, Dogru SC, Arslan YZ. EFFECTS OF HIGH-DOSE VITAMIN C AND HYALURONIC ACID ON TENDON HEALING. Acta Ortop Bras. 2018;26(2):8285. doi: 10.1590/1413-785220182602182353

Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253258. doi: 10.4161/derm.21923

Oe M, Sakai S, Yoshida H, et al. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clin Cosmet Investig Dermatol. 2017;10:267273. Published 2017 Jul 18. doi: 10.2147/CCID.S141845

Jegasothy SM, Zabolotniaia V, Bielfeldt S. Efficacy of a New Topical Nano-hyaluronic Acid in Humans. J Clin Aesthet Dermatol. 2014;7(3):2729. PMID: 24688623

Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019;6:192. Published 2019 Jun 25. doi: 10.3389/fvets.2019.00192

Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014;13:70. Published 2014 Jul 11. doi: 10.1186/1475-2891-13-70

Bowman S, Awad ME, Hamrick MW, Hunter M, Fulzele S. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin Transl Med. 2018;7(1):6. Published 2018 Feb 16. doi: 10.1186/s40169-017-0180-3

Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. ScientificWorldJournal. 2012;2012:167928. doi: 10.1100/2012/167928

Altman, R., Hackel, J., Niazi, F., Shaw, P., & Nicholls, M. (2018). Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review. Seminars in arthritis and rheumatism, 48(2), 168175. DOI: 10.1016/j.semarthrit.2018.01.009

Concoff, A., Sancheti, P., Niazi, F., Shaw, P., & Rosen, J. (2017). The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis. BMC musculoskeletal disorders, 18(1), 542. DOI: 10.1186/s12891-017-1897-2

Altman, R. D., Bedi, A., Karlsson, J., Sancheti, P., & Schemitsch, E. (2016). Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. The American journal of sports medicine, 44(8), 21582165. DOI: 10.1177/0363546515609599

Witteveen, A. G., Hofstad, C. J., & Kerkhoffs, G. M. (2015). Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle. The Cochrane database of systematic reviews, (10), CD010643. DOI: 10.1002/14651858.CD010643.pub2

Wu M, Cronin K, Crane JS. Biochemistry, Collagen Synthesis. [Updated 2020 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. 

Boyera, N., Galey, I., & Bernard, B. A. (1998). Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International journal of cosmetic science, 20(3), 151158. DOI: 10.1046/j.1467-2494.1998.171747.x

Lis, D. M., & Baar, K. (2019). Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. International journal of sport nutrition and exercise metabolism, 29(5), 526531. DOI: 10.1123/ijsnem.2018-0385

Kleszczewska E. (2007). Biologiczne znaczenie witaminy C ze szczególnym z uwzglednieniem jej znaczenia w metabolizmie skóry [Biological role and importance in the skin metabolism of vitamin C]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 23(138), 462465. PMID: 18432133

DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF. Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop J Sports Med. 2018;6(10):2325967118804544. Published 2018 Oct 25. doi: 10.1177/2325967118804544

Moores J. (2013). Vitamin C: a wound healing perspective. British journal of community nursing, Suppl, S6S11. DOI: 10.12968/bjcn.2013.18.sup12.s6

Collins N. (2004). Adding vitamin C to the wound management mix. Advances in skin & wound care, 17(3), 109112. DOI: 10.1097/00129334-200404000-00010

Ronchetti, I. P., Quaglino, D., Jr, & Bergamini, G. (1996). Ascorbic acid and connective tissue. Sub-cellular biochemistry, 25, 249264. DOI: 10.1007/978-1-4613-0325-1_13

Vaxman, F., Olender, S., Lambert, A., Nisand, G., & Grenier, J. F. (1996). Can the wound healing process be improved by vitamin supplementation? Experimental study on humans. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 28(4), 306314. DOI: 10.1159/000129471

Hallberg, L., Brune, M., & Rossander, L. (1989). The role of vitamin C in iron absorption. International journal for vitamin and nutrition research. Supplement = Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Supplement, 30, 103108. PMID: 2507689

Lynch, S. R., & Cook, J. D. (1980). Interaction of vitamin C and iron. Annals of the New York Academy of Sciences, 355, 3244. DOI: 10.1111/j.1749-6632.1980.tb21325.x

Teucher, B., Olivares, M., & Cori, H. (2004). Enhancers of iron absorption: ascorbic acid and other organic acids. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 74(6), 403419. DOI: 10.1024/0300-9831.74.6.403

Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. DOI: 10.3390/nu9111211

Ströhle, A., & Hahn, A. (2009). Vitamin C und Immunfunktion [Vitamin C and immune function]. Medizinische Monatsschrift fur Pharmazeuten, 32(2), 4956. PMID: 19263912

Maheu, E., Rannou, F., & Reginster, J. Y. (2016). Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Seminars in arthritis and rheumatism, 45(4 Suppl), S28S33. DOI: 10.1016/j.semarthrit.2015.11.008

Dincel YM, Adanir O, Arikan Y, Caglar AK, Dogru SC, Arslan YZ. EFFECTS OF HIGH-DOSE VITAMIN C AND HYALURONIC ACID ON TENDON HEALING. Acta Ortop Bras. 2018;26(2):8285. doi: 10.1590/1413-785220182602182353

Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253258. doi: 10.4161/derm.21923

Oe M, Sakai S, Yoshida H, et al. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clin Cosmet Investig Dermatol. 2017;10:267273. Published 2017 Jul 18. doi: 10.2147/CCID.S141845

Jegasothy SM, Zabolotniaia V, Bielfeldt S. Efficacy of a New Topical Nano-hyaluronic Acid in Humans. J Clin Aesthet Dermatol. 2014;7(3):2729. PMID: 24688623

Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019;6:192. Published 2019 Jun 25. doi: 10.3389/fvets.2019.00192

Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014;13:70. Published 2014 Jul 11. doi: 10.1186/1475-2891-13-70

Bowman S, Awad ME, Hamrick MW, Hunter M, Fulzele S. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin Transl Med. 2018;7(1):6. Published 2018 Feb 16. doi: 10.1186/s40169-017-0180-3

Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. ScientificWorldJournal. 2012;2012:167928. doi: 10.1100/2012/167928

Altman, R., Hackel, J., Niazi, F., Shaw, P., & Nicholls, M. (2018). Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review. Seminars in arthritis and rheumatism, 48(2), 168175. DOI: 10.1016/j.semarthrit.2018.01.009

Concoff, A., Sancheti, P., Niazi, F., Shaw, P., & Rosen, J. (2017). The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis. BMC musculoskeletal disorders, 18(1), 542. DOI: 10.1186/s12891-017-1897-2

Altman, R. D., Bedi, A., Karlsson, J., Sancheti, P., & Schemitsch, E. (2016). Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. The American journal of sports medicine, 44(8), 21582165. DOI: 10.1177/0363546515609599

Witteveen, A. G., Hofstad, C. J., & Kerkhoffs, G. M. (2015). Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle. The Cochrane database of systematic reviews, (10), CD010643. DOI: 10.1002/14651858.CD010643.pub2

Wu M, Cronin K, Crane JS. Biochemistry, Collagen Synthesis. [Updated 2020 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. 

Boyera, N., Galey, I., & Bernard, B. A. (1998). Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International journal of cosmetic science, 20(3), 151158. DOI: 10.1046/j.1467-2494.1998.171747.x

Lis, D. M., & Baar, K. (2019). Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. International journal of sport nutrition and exercise metabolism, 29(5), 526531. DOI: 10.1123/ijsnem.2018-0385

Kleszczewska E. (2007). Biologiczne znaczenie witaminy C ze szczególnym z uwzglednieniem jej znaczenia w metabolizmie skóry [Biological role and importance in the skin metabolism of vitamin C]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 23(138), 462465. PMID: 18432133

DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF. Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop J Sports Med. 2018;6(10):2325967118804544. Published 2018 Oct 25. doi: 10.1177/2325967118804544

Moores J. (2013). Vitamin C: a wound healing perspective. British journal of community nursing, Suppl, S6S11. DOI: 10.12968/bjcn.2013.18.sup12.s6

Collins N. (2004). Adding vitamin C to the wound management mix. Advances in skin & wound care, 17(3), 109112. DOI: 10.1097/00129334-200404000-00010

Ronchetti, I. P., Quaglino, D., Jr, & Bergamini, G. (1996). Ascorbic acid and connective tissue. Sub-cellular biochemistry, 25, 249264. DOI: 10.1007/978-1-4613-0325-1_13

Vaxman, F., Olender, S., Lambert, A., Nisand, G., & Grenier, J. F. (1996). Can the wound healing process be improved by vitamin supplementation? Experimental study on humans. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 28(4), 306314. DOI: 10.1159/000129471

Hallberg, L., Brune, M., & Rossander, L. (1989). The role of vitamin C in iron absorption. International journal for vitamin and nutrition research. Supplement = Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Supplement, 30, 103108. PMID: 2507689

Lynch, S. R., & Cook, J. D. (1980). Interaction of vitamin C and iron. Annals of the New York Academy of Sciences, 355, 3244. DOI: 10.1111/j.1749-6632.1980.tb21325.x

Teucher, B., Olivares, M., & Cori, H. (2004). Enhancers of iron absorption: ascorbic acid and other organic acids. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 74(6), 403419. DOI: 10.1024/0300-9831.74.6.403

Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. DOI: 10.3390/nu9111211

Ströhle, A., & Hahn, A. (2009). Vitamin C und Immunfunktion [Vitamin C and immune function]. Medizinische Monatsschrift fur Pharmazeuten, 32(2), 4956. PMID: 19263912

Maheu, E., Rannou, F., & Reginster, J. Y. (2016). Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Seminars in arthritis and rheumatism, 45(4 Suppl), S28S33. DOI: 10.1016/j.semarthrit.2015.11.008

Un multicolágeno como ningún otro.

La fusión de cinco tipos distintos de colágeno en su núcleo crea sinergia con una matriz compleja de biotina, multivitaminas y queratina. Esta mezcla orquestada es más que una fórmula; es un tejido ingenioso de los mejores elementos de la naturaleza. La belleza inherente de la biotina, la nutrición saludable de las multivitaminas y la integridad estructural de la queratina se fusionan en una mezcla armoniosa.

MULTIVITAMINAS Y 18 AMINOÁCIDOS.

Los paquetes de barras Codeage Multi Collagen Platinum son su potencia todo en uno: combinan cinco tipos de colágeno premium con vitamina C, D3, B6 y niacina y ofrecen 18 aminoácidos diferentes.
Codeage Multi Collagen Platinum Stick Photography 1

BIOTINA Y ÁCIDO HIALURÓNICO.

Los paquetes de barras Codeage Multi Collagen Platinum están fortificados con 10,000 mcg de biotina por porción y queratina innovadora hidrolizada para ayudar a fortalecer el cabello, la piel y las uñas.* La biotina puede actuar como un catalizador, promoviendo el crecimiento y la textura, mientras que la queratina puede ayudar a proporcionar fuerza fundamental. reforzando tu belleza natural desde dentro.*
Codeage Multi Collagen Platinum Stick Photography 2

INCUESTIONABLEMENTE PURA.

Esta fórmula avanzada de colágeno en polvo contiene colágeno bovino hidrolizado, criado en pastos y alimentado con pasto para una pureza inigualable en cada barra conveniente, lo que garantiza que su viaje hacia una vida más saludable sea lo más auténtico posible.
Codeage Multi Collagen Platinum Stick Photography 3

USO SUGERIDO.

Los adultos mezclan 1 paquete con 8 onzas líquidas de café caliente, líquido caliente o su bebida favorita. ¡Mezcla bien y disfruta!

VER PRECAUCIÓN

PRECAUCIÓN: No exceda la dosis recomendada. Tenga cuidado si tiene alergias o sensibilidades a alguno de los ingredientes enumerados. Las madres embarazadas o lactantes y las personas con una afección médica conocida deben consultar a un médico antes de usar este o cualquier suplemento dietético. Utilizar sólo según las indicaciones. Algunas personas pueden experimentar una ligera intolerancia a los productos marinos o bovinos. Si experimenta molestias gastrointestinales (incluyendo hinchazón, calambres, diarrea u otros trastornos digestivos) u otra sensibilidad, deje de tomar el producto inmediatamente. Algunas personas son alérgicas a la carne bovina (carne de res) o al pescado. Si está embarazada, amamantando o tiene una condición médica, consulte con su médico antes de usarlo. Si tiene alguna pregunta sobre el consumo de este suplemento dietético, consulte con su profesional de la salud antes de usarlo. Si usa medicamentos recetados o de venta libre, desconoce su condición médica actual o tiene una condición médica preexistente, consulte con su profesional de la salud antes de usarlos. Suspenda su uso inmediatamente si experimenta algún síntoma o reacción adversa mientras toma este producto. Suspenda su uso 2 semanas antes de la cirugía. No lo use si se desconoce su estado de salud. No lo utilice si el sello de seguridad está dañado o falta. Mantener fuera del alcance de los niños y las mascotas. Conservar en un lugar fresco y seco, alejado de la humedad del calor. La biotina se puede obtener en cantidades adecuadas o adicionales únicamente a través de los alimentos y la dieta habitual. Utilice este producto únicamente como complemento alimenticio. No utilice para la reducción de peso.

DETALLES ADICIONALES.

Multi Colágeno con Biotina Queratina y Multivitaminas
Ver Referencias

Referencias

Biotin: an essential B vitamin involved in a number of specific biological reactions responsible for the metabolism of fats, glucose and amino acids

Biotin. Fact Sheet for Health Professionals.  NIH.  https://ods.od.nih.gov/factsheets/Biotin-HealthProfessional/

Vitamin C: antioxidant support, collagen synthesis, skin & hair health

One of vitamin Cs essential functions is to serve as an antioxidant, protecting the body from excessive oxidation.  Vitamin C plays a pivotal role in the regeneration of vitamin E, another important antioxidant.

Vitamin C.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/

Vitamin C is required to support synthesis of collagen in the body.  Collagen is the major component of the bodys connective tissue.

Vitamin C.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/

Vitamin C supports skin health in two ways: as an antioxidant and as a required cofactor for production of collagen in the body.  References for these roles are provided above.

Skin dermal and epidermal layers contain relatively high amounts of vitamin C.  Age and UV exposure can reduce tissue levels.

Skin Health.  Linus Pauling Institute. Oregon State University. https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-C

Vitamin D, from diet and production within the skin, play a vital role in skin health.  More specifically, vitamin D in skin plays a critical role in regulating the proliferation and differentiation of keratinocytes, the cells responsible for producing the structural protein keratin. This process ensures normal cell growth and maintains the skin barrier. Vitamin D has also been shown to be involved in maintaining the growth cycle of mature hair follicles.

Vitamin D.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/

Vitamin D and Skin Health.  Linus Pauling Institute. Oregon State University.  https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-D

Vitamin B6: essential in the metabolism of protein, fat, carbohydrates

Vitamin B6 is found in 6 forms all of which can be utilized.  Two forms, Pyridoxal 5 phosphate (PLP) and pyridoxamine 5 phosphate (PMP) are the active coenzyme forms of vitamin B6. Vitamin B6 in coenzyme forms performs a wide variety of functions in the body, with involvement in more than 100 enzyme reactions, primarily concerned with protein metabolism. Both PLP and PMP are involved in amino acid metabolism, and PLP is also involved in the metabolism of one-carbon units, carbohydrates, and lipids 

Vitamin B6.  Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/vitaminb6-healthprofessional/

Pantothenic acid: essential in fatty acid metabolism

The primary functions of Pantothenic acid involve the synthesis of coenzyme A (CoA) and acyl carrier protein, both of which are involved in the metabolism of fatty acids.

Pantothenic acid. Health Professional Fact Sheet. NIH. https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/

Hydrolyzed keratin protein: a source of amino acids used by the body form new protein

Keratin is a major structural protein in hair and nails.

Composition of hair and nails ( and overview of conditions):

J McKittrick, PY Chen, SG Bodde, W Yang The structure, functions, and mechanical properties of keratin.- Jom, 2012

http://meyersgroup.ucsd.edu/papers/journals/Meyers%20354.pdf

P Grinzi. Hair and nails.  - Australian Family Physician, 2011

https://www.racgp.org.au/getattachment/065396cf-bb0c-4fd6-99fb-63fa5a3770b1/Hair-and-nails.aspx

Hyaluronic acid: joint & skin health

HA supports joint lubrication. Several human studies in persons who are healthy as well as those with osteoarthritis, experienced reduction in knee pain following ingestion of oral HA.  Various daily doses were studied (80 mg-630 mg) and all showed benefit. (The complex molecule hyaluronan is found in the joint space where if lubricates and cushions joints.)

Oe M, Tashiro T, Yoshida H, Nishiyama H, Masuda Y, Maruyama K, Koikeda T, Maruya R, Fukui N. Oral hyaluronan relieves knee pain: a review. Nutr J. 2016 Jan 27;15:11. doi: 10.1186/s12937-016-0128-2. PMID: 26818459; PMCID: PMC4729158.

HA supports skin hydration. Hyaluronic acid is a building block of hyaluronan, a complex molecule found in the extracellular matrix of tissues such as skin, eye and joints.  It plays a role in lubrication of joints and is important in maintaining skin moisture. 

Oral supplementation with HA has been shown in at least 6 human studies to improve skin moisture content.  These studies have been reviewed by Kawada et al.  Studies examined a range of doses (37.5 mg HA per day to 240 mg HA per day-3 studies at 120 mg HA per day). The consumption period ranged from 4 to 12 weeks, with all time periods showing benefit.

Kawada C, Yoshida T, Yoshida H, Matsuoka R, Sakamoto W, Odanaka W, Sato T, Yamasaki T, Kanemitsu T, Masuda Y, Urushibata O. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014 Jul 11;13:70. doi: 10.1186/1475-2891-13-70. PMID: 25014997; PMCID: PMC4110621.

Grass-Fed Hydrolyzed Bovine Collagen

Vollmer DL, West VA, Lephart ED. Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome. Int J Mol Sci. 2018;19(10):3059. Published 2018 Oct 7. doi: 10.3390/ijms19103059

Saha A, Alam MJ, Ashraf KU, Mannan A. Computational analysis of bovine alpha-1 collagen sequences. Bioinformation. 2013;9(1):4248. doi: 10.6026/97320630009042

León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed Collagen-Sources and Applications. Molecules. 2019;24(22):4031. Published 2019 Nov 7. doi: 10.3390/molecules24224031

K. Henriksen, M.A. Karsdal, in Biochemistry of Collagens, Laminins and Elastin, 2016

Albaugh VL, Mukherjee K, Barbul A. Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing. J Nutr. 2017;147(11):20112017. doi:10.3945/jn.117.256404

Avila Rodríguez, MI, Rodríguez Barroso, LG, Sánchez, ML. Collagen: A review on its sources and potential cosmetic applications. J Cosmet. Dermatol. 2018; 17: 20 26. DOI: 10.1111/jocd.12450

Paul C, Leser S, Oesser S. Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance. Nutrients. 2019;11(5):1079. Published 2019 May 15.  doi: 10.3945/jn.117.256404

Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2014). Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin pharmacology and physiology, 27(1), 4755. DOI: 10.1159/000351376

Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015;114(8):12371245. doi: 10.1017/S0007114515002810

Organic Chicken Bone Broth

Crowley DC, Lau FC, Sharma P, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009;6(6):312321. Published 2009 Oct 9. doi: 10.7150/ijms.6.312

Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016;48(2):95101. doi: 10.5152/eurasianjmed.2015.15030

Lugo, J.P., Saiyed, Z.M. & Lane, N.E. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J 15, 14 (2015). DOI: 10.1186/s12937-016-0130-8

Bagchi, D., Misner, B., Bagchi, M., Kothari, S. C., Downs, B. W., Fafard, R. D., & Preuss, H. G. (2002). Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. International journal of clinical pharmacology research, 22(3-4), 101110.

Zhu, P., Li, X. Y., Wang, H. K., Jia, J. F., Zheng, Z. H., Ding, J., & Fan, C. M. (2007). Oral administration of type-II collagen peptide 250-270 suppresses specific cellular and humoral immune response in collagen-induced arthritis. Clinical immunology (Orlando, Fla.), 122(1), 7584. DOI: 10.1016/j.clim.2006.08.004

Barnett, M. L., Kremer, J. M., St Clair, E. W., Clegg, D. O., Furst, D., Weisman, M., Fletcher, M. J., Chasan-Taber, S., Finger, E., Morales, A., Le, C. H., & Trentham, D. E. (1998). Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis and rheumatism, 41(2), 290297. DOI: 10.1002/1529-0131(199802)41:2<290::AID-ART13>3.0.CO;2-R

Yoshinari, O., Moriyama, H., & Shiojima, Y. (2015). An overview of a novel, water-soluble undenatured type II collagen (NEXT-II). Journal of the American College of Nutrition, 34(3), 255262. DOI: 10.1080/07315724.2014.919541

Paul, C., Leser, S., & Oesser, S. (2019). Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance. Nutrients, 11(5), 1079. DOI: 10.3390/nu11051079

Darling, A. L., Manders, R., Sahni, S., Zhu, K., Hewitt, C. E., Prince, R. L., Millward, D. J., & Lanham-New, S. A. (2019). Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 30(4), 741761. DOI: 10.1007/s00198-019-04933-8

Lerman, R. H., Chang, J. L., Konda, V., Desai, A., & Montalto, M. B. (2015). Nutritional Approach for Relief of Joint Discomfort: A 12-week, Open-case Series and Illustrative Case Report. Integrative medicine (Encinitas, Calif.), 14(5), 5261. PMCID: PMC4712866

Biotin

Glynis A. A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2012;5(11):28-34. PMID: 23198010

Janos Zempleni, Yousef I Hassan & Subhashinee SK Wijeratne (2008) Biotin and biotinidase deficiency, Expert Review of Endocrinology & Metabolism, 3:6, 715-724, DOI: 10.1586/17446651.3.6.715

Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166169. doi: 10.1159/000462981

Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166169. doi: 10.1159/000462981

S. Daniells and G. Hardy, Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame? Current Opinion in Clinical Nutrition & Metabolic Care, vol. 13, no. 6, pp. 690697, November 2010. doi: 10.1097/MCO.0b013e32833ece02

Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008;3(6):715724. doi: 10.1586/17446651.3.6.715

2008;3(6):715724. doi: 10.1586/17446651.3.6.715

Sparavigna A, Tenconi B, La Penna L. Efficacy and tolerability of a biomineral formulation for treatment of onychoschizia: a randomized trial. Clin Cosmet Investig Dermatol. 2019;12:355362. Published 2019 May 13. doi: 10.2147/CCID.S187305

Lipner, S. R., & Scher, R. K. (2018). Biotin for the treatment of nail disease: what is the evidence?. The Journal of dermatological treatment, 29(4), 411414. DOI: 10.1080/09546634.2017.1395799

Victor E. Colombo, Françoise Gerber, Max Bronhofer, George L. Floersheim. Treatment of brittle fingernails and onychoschizia with biotin: Scanning electron microscopy. Colombo, Victor E. et al. Journal of the American Academy of Dermatology, Volume 23, Issue 6, 1127 1132. DOI: https://doi.org/10.1016/0190-9622(90)70345-I

Trüeb RM. Serum Biotin Levels in Women Complaining of Hair Loss. Int J Trichology. 2016;8(2):73-77. doi: 10.4103/0974-7753.188040

Floersheim G. L. (1989). Behandlung brüchiger Fingernägel mit Biotin [Treatment of brittle fingernails with biotin]. Zeitschrift fur Hautkrankheiten, 64(1), 4148. PMID: 2648686

Hochman, L. G., Scher, R. K., & Meyerson, M. S. (1993). Brittle nails: response to daily biotin supplementation. Cutis, 51(4), 303305. PMID: 8477615

Scheinfeld, N., Dahdah, M. J., & Scher, R. (2007). Vitamins and minerals: their role in nail health and disease. Journal of drugs in dermatology : JDD, 6(8), 782787. PMID: 17763607

Keratin

Gavazzoni Dias MF. Hair cosmetics: an overview. Int J Trichology. 2015;7(1):215. doi: 10.4103/0974-7753.153450

Bragulla HH, Homberger DG. Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia. J Anat. 2009;214(4):516559. doi: 10.1111/j.1469-7580.2009.01066.x

Basit A, Asghar F, Sadaf S, Akhtar MW. Health improvement of human hair and their reshaping using recombinant keratin K31. Biotechnol Rep (Amst). 2018;20:e00288. Published 2018 Oct 24. doi: 10.1016/j.btre.2018.e00288

Villa, A.L.V., Aragão, M.R.S., dos Santos, E.P. et al. Feather keratin hydrolysates obtained from microbial keratinases: effect on hair fiber. BMC Biotechnol 13, 15 (2013). DOI: 10.1186/1472-6750-13-15

Narda, Mridvika & Aladren, Sonia & Cestone, Enza & Nobile, Vincenzo. (2017). Efficacy and Safety of a Food Supplement Containing L-cystine, Serenoa repens Extract and Biotin for Hair Loss in Healthy Males and Females. A Prospective, Randomized, Double-blinded, Controlled Clinical Trial. Journal of Cosmetology & Trichology. DOI: 10.4172/2471-9323.1000127

Sando, L., Kim, M., Colgrave, M.L., Ramshaw, J.A.M., Werkmeister, J.A. and Elvin, C.M. (2010), Photochemical crosslinking of soluble wool keratins produces a mechanically stable biomaterial that supports cell adhesion and proliferation. J. Biomed. Mater. Res., 95A: 901-911. doi:10.1002/jbm.a.32913

Villa AL, Aragão MR, Dos Santos EP, et al. Feather keratin hydrolysates obtained from microbial keratinases: effect on hair fiber. BMC Biotechnol. 2013;13:15. Published 2013 Feb 18. doi: 10.1186/1472-6750-13-15

Vitamin C & Hyaluronic Acid

Dincel YM, Adanir O, Arikan Y, Caglar AK, Dogru SC, Arslan YZ. EFFECTS OF HIGH-DOSE VITAMIN C AND HYALURONIC ACID ON TENDON HEALING. Acta Ortop Bras. 2018;26(2):8285. doi: 10.1590/1413-785220182602182353

Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253258. doi: 10.4161/derm.21923

Oe M, Sakai S, Yoshida H, et al. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clin Cosmet Investig Dermatol. 2017;10:267273. Published 2017 Jul 18. doi: 10.2147/CCID.S141845

Jegasothy SM, Zabolotniaia V, Bielfeldt S. Efficacy of a New Topical Nano-hyaluronic Acid in Humans. J Clin Aesthet Dermatol. 2014;7(3):2729. PMID: 24688623

Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019;6:192. Published 2019 Jun 25. doi: 10.3389/fvets.2019.00192

Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014;13:70. Published 2014 Jul 11. doi: 10.1186/1475-2891-13-70

Bowman S, Awad ME, Hamrick MW, Hunter M, Fulzele S. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin Transl Med. 2018;7(1):6. Published 2018 Feb 16. doi: 10.1186/s40169-017-0180-3

Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. ScientificWorldJournal. 2012;2012:167928. doi: 10.1100/2012/167928

Altman, R., Hackel, J., Niazi, F., Shaw, P., & Nicholls, M. (2018). Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review. Seminars in arthritis and rheumatism, 48(2), 168175. DOI: 10.1016/j.semarthrit.2018.01.009

Concoff, A., Sancheti, P., Niazi, F., Shaw, P., & Rosen, J. (2017). The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis. BMC musculoskeletal disorders, 18(1), 542. DOI: 10.1186/s12891-017-1897-2

Altman, R. D., Bedi, A., Karlsson, J., Sancheti, P., & Schemitsch, E. (2016). Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. The American journal of sports medicine, 44(8), 21582165. DOI: 10.1177/0363546515609599

Witteveen, A. G., Hofstad, C. J., & Kerkhoffs, G. M. (2015). Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle. The Cochrane database of systematic reviews, (10), CD010643. DOI: 10.1002/14651858.CD010643.pub2

Wu M, Cronin K, Crane JS. Biochemistry, Collagen Synthesis. [Updated 2020 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. 

Boyera, N., Galey, I., & Bernard, B. A. (1998). Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International journal of cosmetic science, 20(3), 151158. DOI: 10.1046/j.1467-2494.1998.171747.x

Lis, D. M., & Baar, K. (2019). Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. International journal of sport nutrition and exercise metabolism, 29(5), 526531. DOI: 10.1123/ijsnem.2018-0385

Kleszczewska E. (2007). Biologiczne znaczenie witaminy C ze szczególnym z uwzglednieniem jej znaczenia w metabolizmie skóry [Biological role and importance in the skin metabolism of vitamin C]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 23(138), 462465. PMID: 18432133

DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF. Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop J Sports Med. 2018;6(10):2325967118804544. Published 2018 Oct 25. doi: 10.1177/2325967118804544

Moores J. (2013). Vitamin C: a wound healing perspective. British journal of community nursing, Suppl, S6S11. DOI: 10.12968/bjcn.2013.18.sup12.s6

Collins N. (2004). Adding vitamin C to the wound management mix. Advances in skin & wound care, 17(3), 109112. DOI: 10.1097/00129334-200404000-00010

Ronchetti, I. P., Quaglino, D., Jr, & Bergamini, G. (1996). Ascorbic acid and connective tissue. Sub-cellular biochemistry, 25, 249264. DOI: 10.1007/978-1-4613-0325-1_13

Vaxman, F., Olender, S., Lambert, A., Nisand, G., & Grenier, J. F. (1996). Can the wound healing process be improved by vitamin supplementation? Experimental study on humans. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 28(4), 306314. DOI: 10.1159/000129471

Hallberg, L., Brune, M., & Rossander, L. (1989). The role of vitamin C in iron absorption. International journal for vitamin and nutrition research. Supplement = Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Supplement, 30, 103108. PMID: 2507689

Lynch, S. R., & Cook, J. D. (1980). Interaction of vitamin C and iron. Annals of the New York Academy of Sciences, 355, 3244. DOI: 10.1111/j.1749-6632.1980.tb21325.x

Teucher, B., Olivares, M., & Cori, H. (2004). Enhancers of iron absorption: ascorbic acid and other organic acids. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 74(6), 403419. DOI: 10.1024/0300-9831.74.6.403

Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. DOI: 10.3390/nu9111211

Ströhle, A., & Hahn, A. (2009). Vitamin C und Immunfunktion [Vitamin C and immune function]. Medizinische Monatsschrift fur Pharmazeuten, 32(2), 4956. PMID: 19263912

Maheu, E., Rannou, F., & Reginster, J. Y. (2016). Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Seminars in arthritis and rheumatism, 45(4 Suppl), S28S33. DOI: 10.1016/j.semarthrit.2015.11.008

Dincel YM, Adanir O, Arikan Y, Caglar AK, Dogru SC, Arslan YZ. EFFECTS OF HIGH-DOSE VITAMIN C AND HYALURONIC ACID ON TENDON HEALING. Acta Ortop Bras. 2018;26(2):8285. doi: 10.1590/1413-785220182602182353

Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253258. doi: 10.4161/derm.21923

Oe M, Sakai S, Yoshida H, et al. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clin Cosmet Investig Dermatol. 2017;10:267273. Published 2017 Jul 18. doi: 10.2147/CCID.S141845

Jegasothy SM, Zabolotniaia V, Bielfeldt S. Efficacy of a New Topical Nano-hyaluronic Acid in Humans. J Clin Aesthet Dermatol. 2014;7(3):2729. PMID: 24688623

Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019;6:192. Published 2019 Jun 25. doi: 10.3389/fvets.2019.00192

Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014;13:70. Published 2014 Jul 11. doi: 10.1186/1475-2891-13-70

Bowman S, Awad ME, Hamrick MW, Hunter M, Fulzele S. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin Transl Med. 2018;7(1):6. Published 2018 Feb 16. doi: 10.1186/s40169-017-0180-3

Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. ScientificWorldJournal. 2012;2012:167928. doi: 10.1100/2012/167928

Altman, R., Hackel, J., Niazi, F., Shaw, P., & Nicholls, M. (2018). Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review. Seminars in arthritis and rheumatism, 48(2), 168175. DOI: 10.1016/j.semarthrit.2018.01.009

Concoff, A., Sancheti, P., Niazi, F., Shaw, P., & Rosen, J. (2017). The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis. BMC musculoskeletal disorders, 18(1), 542. DOI: 10.1186/s12891-017-1897-2

Altman, R. D., Bedi, A., Karlsson, J., Sancheti, P., & Schemitsch, E. (2016). Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. The American journal of sports medicine, 44(8), 21582165. DOI: 10.1177/0363546515609599

Witteveen, A. G., Hofstad, C. J., & Kerkhoffs, G. M. (2015). Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle. The Cochrane database of systematic reviews, (10), CD010643. DOI: 10.1002/14651858.CD010643.pub2

Wu M, Cronin K, Crane JS. Biochemistry, Collagen Synthesis. [Updated 2020 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. 

Boyera, N., Galey, I., & Bernard, B. A. (1998). Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International journal of cosmetic science, 20(3), 151158. DOI: 10.1046/j.1467-2494.1998.171747.x

Lis, D. M., & Baar, K. (2019). Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. International journal of sport nutrition and exercise metabolism, 29(5), 526531. DOI: 10.1123/ijsnem.2018-0385

Kleszczewska E. (2007). Biologiczne znaczenie witaminy C ze szczególnym z uwzglednieniem jej znaczenia w metabolizmie skóry [Biological role and importance in the skin metabolism of vitamin C]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 23(138), 462465. PMID: 18432133

DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF. Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop J Sports Med. 2018;6(10):2325967118804544. Published 2018 Oct 25. doi: 10.1177/2325967118804544

Moores J. (2013). Vitamin C: a wound healing perspective. British journal of community nursing, Suppl, S6S11. DOI: 10.12968/bjcn.2013.18.sup12.s6

Collins N. (2004). Adding vitamin C to the wound management mix. Advances in skin & wound care, 17(3), 109112. DOI: 10.1097/00129334-200404000-00010

Ronchetti, I. P., Quaglino, D., Jr, & Bergamini, G. (1996). Ascorbic acid and connective tissue. Sub-cellular biochemistry, 25, 249264. DOI: 10.1007/978-1-4613-0325-1_13

Vaxman, F., Olender, S., Lambert, A., Nisand, G., & Grenier, J. F. (1996). Can the wound healing process be improved by vitamin supplementation? Experimental study on humans. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 28(4), 306314. DOI: 10.1159/000129471

Hallberg, L., Brune, M., & Rossander, L. (1989). The role of vitamin C in iron absorption. International journal for vitamin and nutrition research. Supplement = Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Supplement, 30, 103108. PMID: 2507689

Lynch, S. R., & Cook, J. D. (1980). Interaction of vitamin C and iron. Annals of the New York Academy of Sciences, 355, 3244. DOI: 10.1111/j.1749-6632.1980.tb21325.x

Teucher, B., Olivares, M., & Cori, H. (2004). Enhancers of iron absorption: ascorbic acid and other organic acids. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 74(6), 403419. DOI: 10.1024/0300-9831.74.6.403

Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. DOI: 10.3390/nu9111211

Ströhle, A., & Hahn, A. (2009). Vitamin C und Immunfunktion [Vitamin C and immune function]. Medizinische Monatsschrift fur Pharmazeuten, 32(2), 4956. PMID: 19263912

Maheu, E., Rannou, F., & Reginster, J. Y. (2016). Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Seminars in arthritis and rheumatism, 45(4 Suppl), S28S33. DOI: 10.1016/j.semarthrit.2015.11.008

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