$27.99
All-Skin Types

Clearface Vitamins.

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All-Skin Types

Clearface Vitamins.

Face and skin vitamins.

$27.99
Pamper your face and skin with Codeage Clearface, an all-in-one, vegan & whole-food supplement with vitamins A, C, D3, E, niacin, riboflavin, pantothenic acid, minerals, phytoceramides, probiotics, omega-3, L-lysine HC, and herbal blend.
  • All-in-one formula for skin health support, featuring vegan and whole-food vitamins A, C, D3, and E, as well as essential minerals like zinc, selenium, and copper in amino acid chelate form.*
  • Formulated with a powerful blend of phytoceramides, manganese, chromium, MSM, matcha green tea leaf powder, and milk thistle seed extract to help support your face and skin.*
  • This face vitamins and skin supplement includes L-Lysine HCL, riboflavin, pantothenic acid, niacin as niacinamide, probiotics, vegan omega-3, and an herbal blend to help enhance the effects of this supplement further.*
  • Manufactured in a cGMP-certified facility in the USA with global ingredients and 3rd party tested, this skin vitamins supplement is vegan, non-GMO, keto-friendly, gluten-free, soy-free, dairy-free, and suitable for both women and men.
  • Available in your choice of white or black bottles, this 1-month supply supplement can be added to your existing skin health regimen or used in conjunction with a vitamin serum for the face. Vitamin C and Vitamin E may help in the role of skin elasticity and the appearance of dark spots. A Clearface formula is also available for teens.
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    Supplement Facts

    Supplement Facts

    Ingredients

    Vitamin A (as Beta-Carotene; from Blakeslea trispora), Vitamin C (as L-Ascorbic Acid), Vitamin D3 (as Cholecalciferol; from Wild Harvested Lichen), Vitamin E (from Rice Bran; containing Alpha, Beta, Gamma, & Delta Tocopherols), Thiamin (as Thiamine HCI), Riboflavin, Niacin (as Niacinamide), Pantothenic Acid (as D-Calcium Pantothenate), Iodine (from Organic Kelp), Zinc (as Amino Acid Chelate), Selenium (as Amino Acid Chelate), Copper (as Amino Acid Chelate), Manganese (as Citrate), Chromium (as Picolinate; Organically Bound with GTF Activity), L-Lysine HCL, Vegan Omega-3 (Eicosapentaenoic Acid & Docosahexaenoic Acid), Skin Cleanse & Detox Blend: Milk Thistle Seed Extract (Std. to 80% Silymarin), Spirulina Algae Powder, Matcha Green Tea Leaf Powder, Dandelion Leaf Extract 4:1, Beet Root Powder, Methylsulfonylmethane (MSM), L-Proline, Organic Chlorella Algae Powder, Horsetail Aerial Parts Extract, Oregon Grape Powder (Root), Alpha Lipoic Acid; Probiotic Blend (10 Billion CFU‡): L. rhamnosus (2 Billion CFU), La-14® (L. acidophilus; 3 Billion CFU), B. bifidum (1 Billion CFU), Lc-11® (L. casei; 2 Billion CFU), Lp-115® (L. plantarum; 2 Billion CFU); Rice Phytoceramide Extract, BioPerine® (Black Pepper Extract; Fruit; Piper nigrum). Other Ingredients: Methylcellulose Capsule.

    Elevate your radiance.

    Multivitamin - Minerals - Probiotics
    Omega-3 - Plants & Herbs - L-Lysine
    Same formula available in 2 colors

    Codeage vitamins for skin and face

    Product Details

    • All-in-one formula for skin health support, featuring vegan and whole-food vitamins A, C, D3, and E, as well as essential minerals like zinc, selenium, and copper in amino acid chelate form.*
    • Formulated with a powerful blend of phytoceramides, manganese, chromium, MSM, matcha green tea leaf powder, and milk thistle seed extract to help support your face and skin.*
    • This face vitamins and skin supplement includes L-Lysine HCL, riboflavin, pantothenic acid, niacin as niacinamide, probiotics, vegan omega-3, and an herbal blend to help enhance the effects of this supplement further.*
    • Manufactured in a cGMP-certified facility in the USA with global ingredients and 3rd party tested, this skin vitamins supplement is vegan, non-GMO, keto-friendly, gluten-free, soy-free, dairy-free, and suitable for both women and men.
    • Available in your choice of white or black bottles, this 1-month supply supplement can be added to your existing skin health regimen or used in conjunction with a vitamin serum for the face. Vitamin C and Vitamin E may help in the role of skin elasticity and the appearance of dark spots. A Clearface formula is also available for teens.

    Supplement Facts

    Supplement Facts

    Ingredients

    Vitamin A (as Beta-Carotene; from Blakeslea trispora), Vitamin C (as L-Ascorbic Acid), Vitamin D3 (as Cholecalciferol; from Wild Harvested Lichen), Vitamin E (from Rice Bran; containing Alpha, Beta, Gamma, & Delta Tocopherols), Thiamin (as Thiamine HCI), Riboflavin, Niacin (as Niacinamide), Pantothenic Acid (as D-Calcium Pantothenate), Iodine (from Organic Kelp), Zinc (as Amino Acid Chelate), Selenium (as Amino Acid Chelate), Copper (as Amino Acid Chelate), Manganese (as Citrate), Chromium (as Picolinate; Organically Bound with GTF Activity), L-Lysine HCL, Vegan Omega-3 (Eicosapentaenoic Acid & Docosahexaenoic Acid), Skin Cleanse & Detox Blend: Milk Thistle Seed Extract (Std. to 80% Silymarin), Spirulina Algae Powder, Matcha Green Tea Leaf Powder, Dandelion Leaf Extract 4:1, Beet Root Powder, Methylsulfonylmethane (MSM), L-Proline, Organic Chlorella Algae Powder, Horsetail Aerial Parts Extract, Oregon Grape Powder (Root), Alpha Lipoic Acid; Probiotic Blend (10 Billion CFU‡): L. rhamnosus (2 Billion CFU), La-14® (L. acidophilus; 3 Billion CFU), B. bifidum (1 Billion CFU), Lc-11® (L. casei; 2 Billion CFU), Lp-115® (L. plantarum; 2 Billion CFU); Rice Phytoceramide Extract, BioPerine® (Black Pepper Extract; Fruit; Piper nigrum). Other Ingredients: Methylcellulose Capsule.

    Suggested Use

    Adults take 3 capsules daily with 8 ounces of water or your favorite beverage or as directed by a qualified healthcare practitioner. CAUTION: Do not exceed the recommended dose.

    CAUTION: Do not exceed recommended dose. Please use caution if you have allergies or sensitivities to any of the listed ingredients. Pregnant or nursing mothers and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Use only as directed. If gastrointestinal discomfort (including bloating, cramps, diarrhea, or other digestive upset) or other sensitivity is experienced stop taking the product immediately. If you are pregnant, nursing, or have a medical condition, please consult with your physician before use. If you have any questions about consuming this dietary supplement, consult with your healthcare provider before using. If you use prescription drugs or over-the-counter medications, are unaware of your current medical condition or have a pre-existing medical condition(s), consult with your health care professional before using. Discontinue use immediately if you experience any adverse symptoms or reactions while taking this product. Discontinue use 2 weeks prior to surgery. Do not use if your health status is unknown. Do not use if safety seal is damaged or missing. Keep out of reach of children and pets. Store in a cool, dry place, away from heat moisture. Use this product as a food supplement only. Do not use for weight reduction.

    References

    Vitamins & Minerals

    Mrinal Gupta, Vikram K. Mahajan, Karaninder S. Mehta, Pushpinder S. Chauhan, "Zinc Therapy in Dermatology: A Review", Dermatology Research and Practice, vol. 2014, Article ID 709152, 11 pages, 2014. DOI: 10.1155/2014/709152

    Brandt, Staci. The clinical effects of zinc as a topical or oral agent on the clinical response and pathophysiologic mechanisms of acne: a systematic review of the literature. Journal of drugs in dermatology : JDD vol. 12,5 (2013): 542-5. PMID: 23652948

    Dreno, B et al. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate in the treatment of inflammatory acne vulgaris. Dermatology (Basel, Switzerland) vol. 203,2 (2001): 135-40. DOI: 10.1159/000051728

    Yee, Brittany E et al. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatologic therapy, e14252. 29 Aug. 2020, DOI: 10.1111/dth.14252

    Dhaliwal, Simran et al. Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence. American journal of clinical dermatology vol. 21,1 (2020): 21-39. DOI: 10.1007/s40257-019-00484-0

    Ozuguz, Pinar et al. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutaneous and ocular toxicology vol. 33,2 (2014): 99-102. DOI: 10.3109/15569527.2013.808656

    Rostami Mogaddam, Majid et al. Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris. BioMed research international vol. 2014 (2014): 474108. DOI: 10.1155/2014/474108

    Ikaraoha, C I et al. The Role of Blood Lead, Cadmium, Zinc and Copper in Development and Severity of Acne Vulgaris in a Nigerian Population. Biological trace element research vol. 176,2 (2017): 251-257. DOI: 10.1007/s12011-016-0839-4

    Gupta, Mrinal et al. Zinc therapy in dermatology: a review. Dermatology research and practice vol. 2014 (2014): 709152. doi: 10.1155/2014/709152

    Ogawa, Youichi et al. Zinc and Skin Disorders. Nutrients vol. 10,2 199. 11 Feb. 2018, doi: 10.3390/nu10020199

    Keen, Mohammad Abid, and Iffat Hassan. Vitamin E in dermatology. Indian dermatology online journal vol. 7,4 (2016): 311-5. doi: 10.4103/2229-5178.185494

    Nachbar, F, and H C Korting. The role of vitamin E in normal and damaged skin. Journal of molecular medicine (Berlin, Germany) vol. 73,1 (1995): 7-17. DOI: 10.1007/BF00203614

    Schagen, Silke K et al. Discovering the link between nutrition and skin aging. Dermato-endocrinology vol. 4,3 (2012): 298-307. doi: 10.4161/derm.22876

    Eberlein-König, B et al. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E). Journal of the American Academy of Dermatology vol. 38,1 (1998): 45-8. DOI: 10.1016/s0190-9622(98)70537-7

    Kafi, Reza et al. Improvement of naturally aged skin with vitamin A (retinol). Archives of dermatology vol. 143,5 (2007): 606-12. DOI: 10.1001/archderm.143.5.606

    Zasada, Malwina, and Elżbieta Budzisz. Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy dermatologii i alergologii vol. 36,4 (2019): 392-397. doi: 10.5114/ada.2019.87443

    Mukherjee, Siddharth et al. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging vol. 1,4 (2006): 327-48. PMCID: PMC2699641

    Telang, Pumori Saokar. Vitamin C in dermatology. Indian dermatology online journal vol. 4,2 (2013): 143-6. doi: 10.4103/2229-5178.110593

    Pullar, Juliet M et al. The Roles of Vitamin C in Skin Health. Nutrients vol. 9,8 866. 12 Aug. 2017, doi: 10.3390/nu9080866

    Rattanawiwatpong, Pattarawan et al. Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial. Journal of cosmetic dermatology vol. 19,3 (2020): 671-676. doi: 10.1111/jocd.13305

    Umar, Meenakshi et al. Vitamin D and the Pathophysiology of Inflammatory Skin Diseases. Skin pharmacology and physiology vol. 31,2 (2018): 74-86. DOI: 10.1159/000485132

    Mostafa, Wedad Z, and Rehab A Hegazy. Vitamin D and the skin: Focus on a complex relationship: A review. Journal of advanced research vol. 6,6 (2015): 793-804. doi: 10.1016/j.jare.2014.01.011

    Sadat-Ali, Mir et al. Topical delivery of vitamin d3: a randomized controlled pilot study. International journal of biomedical science : IJBS vol. 10,1 (2014): 21-4. PMCID: PMC3976443

    Weber, Günther et al. Vitamin D induces the antimicrobial protein hCAP18 in human skin. The Journal of investigative dermatology vol. 124,5 (2005): 1080-2. DOI: 10.1111/j.0022-202X.2005.23687.x

    Bikle, Daniel D. Vitamin D and the skin. Journal of bone and mineral metabolism vol. 28,2 (2010): 117-30. DOI: 10.1007/s00774-009-0153-8

    Bikle, Daniel D. Vitamin D metabolism and function in the skin. Molecular and cellular endocrinology vol. 347,1-2 (2011): 80-9. DOI: 10.1016/j.mce.2011.05.017

    MacLaughlin, J, and M F Holick. Aging decreases the capacity of human skin to produce vitamin D3. The Journal of clinical investigation vol. 76,4 (1985): 1536-8. DOI: 10.1172/JCI112134

    Holick, M F et al. Photosynthesis of previtamin D3 in human skin and the physiologic consequences. Science (New York, N.Y.) vol. 210,4466 (1980): 203-5. DOI: 10.1126/science.6251551

    L-Lysine HCL & Vegan Omega-3            

    Baldwin, Hilary, and Jerry Tan. Effects of Diet on Acne and Its Response to Treatment. American journal of clinical dermatology, 10.1007/s40257-020-00542-y. 3 Aug. 2020. DOI: 10.1007/s40257-020-00542-y

    Kiefer, David, and Traci Pantuso. Omega-3 fatty acids: An update emphasizing clinical use. Agro food industry hi-tech vol. 23,4 (2012): 10-13. PMID: 24436723

    Huang, Tse-Hung et al. Cosmetic and Therapeutic Applications of Fish Oil's Fatty Acids on the Skin. Marine drugs vol. 16,8 256. 30 Jul. 2018. doi: 10.3390/md16080256

    Pilkington, Suzanne M et al. Omega-3 polyunsaturated fatty acids: photoprotective macronutrients. Experimental dermatology vol. 20,7 (2011): 537-43. DOI: 10.1111/j.1600-0625.2011.01294.x

    Tanghetti, Emil A. The role of inflammation in the pathology of acne. The Journal of clinical and aesthetic dermatology vol. 6,9 (2013): 27-35. PMID: 24062871

    Rubin, Mark G et al. Acne vulgaris, mental health and omega-3 fatty acids: a report of cases. Lipids in health and disease vol. 7 36. 13 Oct. 2008. doi: 10.1186/1476-511X-7-36

    Khayef, Golandam et al. Effects of fish oil supplementation on inflammatory acne. Lipids in health and disease vol. 11 165. 3 Dec. 2012. doi: 10.1186/1476-511X-11-165

    Jung, Jae Yoon et al. Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. Acta dermato-venereologica vol. 94,5 (2014): 521-5. DOI: 10.2340/00015555-1802

    Mirnezami, Mina, and Hoda Rahimi. Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects in Patients with Acne Vulgaris?. Dermatology research and practice vol. 2018 6974045. 29 May. 2018. doi: 10.1155/2018/6974045

    Neukam, K et al. Supplementation of flaxseed oil diminishes skin sensitivity and improves skin barrier function and condition. Skin pharmacology and physiology vol. 24,2 (2011): 67-74. DOI: 10.1159/000321442

    Yamauchi, Mitsuo, and Marnisa Sricholpech. Lysine post-translational modifications of collagen. Essays in biochemistry vol. 52 (2012): 113-33. doi: 10.1042/bse0520113

    Singh, Meenu & Rao, Dowlathabad & Pande, Shivansh & Battu, Sowjanya & Rajeswar Dutt, Kunduri & Ramesh, Mantri. (2011). Medicinal Uses of L-Lysine: Past and Future. International Journal of Research in Pharmaceutical Sciences. 2.

    Niacin, Riboflavin, Thiamin

    Walocko, Frances M et al. The role of nicotinamide in acne treatment. Dermatologic therapy vol. 30,5 (2017): 10.1111/dth.12481. DOI: 10.1111/dth.12481

    Levin, Jacquelyn, and Saira B Momin. How much do we really know about our favorite cosmeceutical ingredients?. The Journal of clinical and aesthetic dermatology vol. 3,2 (2010): 22-41. PMID: 20725560

    Bissett, Donald L et al. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] vol. 31,7 Pt 2 (2005): 860-5; discussion 865. DOI: 10.1111/j.1524-4725.2005.31732

    Matts, Paul & Oblong, John & Bissett, D.L.. (2002). A Review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag. 5. 285-289.

    Park, Sang Min et al. Niacin intake and risk of skin cancer in US women and men. International journal of cancer vol. 140,9 (2017): 2023-2031. doi: 10.1002/ijc.30630

    Mahabadi N, Bhusal A, Banks SW. Riboflavin Deficiency. [Updated 2020 Jul 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.

    Thakur, Kiran & Tomar, Sudhir & Singh, Ashish Kumar & Mandal, Surajit & Arora, Sumit. (2016). Riboflavin and health: A review of recent human research. Critical reviews in food science and nutrition. 57. DOI: 10.1080/10408398.2016.1145104

    Alvarez, O M, and R L Gilbreath. Thiamine influence on collagen during the granulation of skin wounds. The Journal of surgical research vol. 32,1 (1982): 24-31. DOI: 10.1016/0022-4804(82)90180-9

    Probiotic Blend

    Kober, Mary-Margaret, and Whitney P Bowe. The effect of probiotics on immune regulation, acne, and photoaging. International journal of women's dermatology vol. 1,2 85-89. 6 Apr. 2015, doi: 10.1016/j.ijwd.2015.02.001

    Lee, Young Bok et al. Potential Role of the Microbiome in Acne: A Comprehensive Review. Journal of clinical medicine vol. 8,7 987. 7 Jul. 2019. doi: 10.3390/jcm8070987

    Dolan, Keren E et al. Probiotics and Disease: A Comprehensive Summary-Part 6, Skin Health. Integrative medicine (Encinitas, Calif.) vol. 16,4 (2017): 32-41. PMID: 30881255

    Skin Herbals

    Vostálová, Jitka et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules (Basel, Switzerland) vol. 24,6 1022. 14 Mar. 2019. doi: 10.3390/molecules24061022

    Hung, Chi-feng et al. Topical delivery of silymarin constituents via the skin route. Acta pharmacologica Sinica vol. 31,1 (2010): 118-26. doi: 10.1038/aps.2009.186

    Dhanalakshmi, Sivanandhan et al. Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis vol. 25,8 (2004): 1459-65. DOI: 10.1093/carcin/bgh152

    Gunes, Seda et al. In vitro evaluation of Spirulina platensis extract incorporated skin cream with its wound healing and antioxidant activities. Pharmaceutical biology vol. 55,1 (2017): 1824-1832. doi:10.1080/13880209.2017.1331249

    Yang, Yafan, and Shuangshuang Li. Dandelion Extracts Protect Human Skin Fibroblasts from UVB Damage and Cellular Senescence. Oxidative medicine and cellular longevity vol. 2015 (2015): 619560. doi: 10.1155/2015/619560

    OyetakinWhite, Patricia et al. Protective mechanisms of green tea polyphenols in skin. Oxidative medicine and cellular longevity vol. 2012 (2012): 560682. doi: 10.1155/2012/560682

    Katiyar, S K et al. Green tea and skin. Archives of dermatology vol. 136,8 (2000): 989-94. DOI: 10.1001/archderm.136.8.989

    Clifford, Tom et al. The potential benefits of red beetroot supplementation in health and disease. Nutrients vol. 7,4 2801-22. 14 Apr. 2015. doi: 10.3390/nu7042801

    Albaugh, Vance L et al. Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing. The Journal of nutrition vol. 147,11 (2017): 2011-2017. doi: 10.3945/jn.117.256404

    Beitner, H. Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. The British journal of dermatology vol. 149,4 (2003): 841-9. DOI: 10.1046/j.1365-2133.2003.05597.x

    Oregon Health & Science University. "Pepper Compound Could Aid Millions With Vitiligo." ScienceDaily. ScienceDaily, 15 April 2008.

    Elevate your radiance.

    Multivitamin - Minerals - Probiotics
    Omega-3 - Plants & Herbs - L-Lysine
    Same formula available in 2 colors

    Codeage vitamins for skin and face

    SUGGESTED USE.

    Adults take 3 capsules daily with 8 ounces of water or your favorite beverage or as directed by a qualified healthcare practitioner. CAUTION: Do not exceed the recommended dose.

    SEE CAUTION

    CAUTION: Do not exceed recommended dose. Please use caution if you have allergies or sensitivities to any of the listed ingredients. Pregnant or nursing mothers and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Use only as directed. If gastrointestinal discomfort (including bloating, cramps, diarrhea, or other digestive upset) or other sensitivity is experienced stop taking the product immediately. If you are pregnant, nursing, or have a medical condition, please consult with your physician before use. If you have any questions about consuming this dietary supplement, consult with your healthcare provider before using. If you use prescription drugs or over-the-counter medications, are unaware of your current medical condition or have a pre-existing medical condition(s), consult with your health care professional before using. Discontinue use immediately if you experience any adverse symptoms or reactions while taking this product. Discontinue use 2 weeks prior to surgery. Do not use if your health status is unknown. Do not use if safety seal is damaged or missing. Keep out of reach of children and pets. Store in a cool, dry place, away from heat moisture. Use this product as a food supplement only. Do not use for weight reduction.

    ADDITIONAL DETAILS.

    Skin Supplement with Broad-Spectrum Vitamins Minerals and Ingredients
    See References

    References

    Vitamins & Minerals

    Mrinal Gupta, Vikram K. Mahajan, Karaninder S. Mehta, Pushpinder S. Chauhan, "Zinc Therapy in Dermatology: A Review", Dermatology Research and Practice, vol. 2014, Article ID 709152, 11 pages, 2014. DOI: 10.1155/2014/709152

    Brandt, Staci. The clinical effects of zinc as a topical or oral agent on the clinical response and pathophysiologic mechanisms of acne: a systematic review of the literature. Journal of drugs in dermatology : JDD vol. 12,5 (2013): 542-5. PMID: 23652948

    Dreno, B et al. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate in the treatment of inflammatory acne vulgaris. Dermatology (Basel, Switzerland) vol. 203,2 (2001): 135-40. DOI: 10.1159/000051728

    Yee, Brittany E et al. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatologic therapy, e14252. 29 Aug. 2020, DOI: 10.1111/dth.14252

    Dhaliwal, Simran et al. Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence. American journal of clinical dermatology vol. 21,1 (2020): 21-39. DOI: 10.1007/s40257-019-00484-0

    Ozuguz, Pinar et al. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutaneous and ocular toxicology vol. 33,2 (2014): 99-102. DOI: 10.3109/15569527.2013.808656

    Rostami Mogaddam, Majid et al. Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris. BioMed research international vol. 2014 (2014): 474108. DOI: 10.1155/2014/474108

    Ikaraoha, C I et al. The Role of Blood Lead, Cadmium, Zinc and Copper in Development and Severity of Acne Vulgaris in a Nigerian Population. Biological trace element research vol. 176,2 (2017): 251-257. DOI: 10.1007/s12011-016-0839-4

    Gupta, Mrinal et al. Zinc therapy in dermatology: a review. Dermatology research and practice vol. 2014 (2014): 709152. doi: 10.1155/2014/709152

    Ogawa, Youichi et al. Zinc and Skin Disorders. Nutrients vol. 10,2 199. 11 Feb. 2018, doi: 10.3390/nu10020199

    Keen, Mohammad Abid, and Iffat Hassan. Vitamin E in dermatology. Indian dermatology online journal vol. 7,4 (2016): 311-5. doi: 10.4103/2229-5178.185494

    Nachbar, F, and H C Korting. The role of vitamin E in normal and damaged skin. Journal of molecular medicine (Berlin, Germany) vol. 73,1 (1995): 7-17. DOI: 10.1007/BF00203614

    Schagen, Silke K et al. Discovering the link between nutrition and skin aging. Dermato-endocrinology vol. 4,3 (2012): 298-307. doi: 10.4161/derm.22876

    Eberlein-König, B et al. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E). Journal of the American Academy of Dermatology vol. 38,1 (1998): 45-8. DOI: 10.1016/s0190-9622(98)70537-7

    Kafi, Reza et al. Improvement of naturally aged skin with vitamin A (retinol). Archives of dermatology vol. 143,5 (2007): 606-12. DOI: 10.1001/archderm.143.5.606

    Zasada, Malwina, and Elżbieta Budzisz. Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy dermatologii i alergologii vol. 36,4 (2019): 392-397. doi: 10.5114/ada.2019.87443

    Mukherjee, Siddharth et al. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging vol. 1,4 (2006): 327-48. PMCID: PMC2699641

    Telang, Pumori Saokar. Vitamin C in dermatology. Indian dermatology online journal vol. 4,2 (2013): 143-6. doi: 10.4103/2229-5178.110593

    Pullar, Juliet M et al. The Roles of Vitamin C in Skin Health. Nutrients vol. 9,8 866. 12 Aug. 2017, doi: 10.3390/nu9080866

    Rattanawiwatpong, Pattarawan et al. Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial. Journal of cosmetic dermatology vol. 19,3 (2020): 671-676. doi: 10.1111/jocd.13305

    Umar, Meenakshi et al. Vitamin D and the Pathophysiology of Inflammatory Skin Diseases. Skin pharmacology and physiology vol. 31,2 (2018): 74-86. DOI: 10.1159/000485132

    Mostafa, Wedad Z, and Rehab A Hegazy. Vitamin D and the skin: Focus on a complex relationship: A review. Journal of advanced research vol. 6,6 (2015): 793-804. doi: 10.1016/j.jare.2014.01.011

    Sadat-Ali, Mir et al. Topical delivery of vitamin d3: a randomized controlled pilot study. International journal of biomedical science : IJBS vol. 10,1 (2014): 21-4. PMCID: PMC3976443

    Weber, Günther et al. Vitamin D induces the antimicrobial protein hCAP18 in human skin. The Journal of investigative dermatology vol. 124,5 (2005): 1080-2. DOI: 10.1111/j.0022-202X.2005.23687.x

    Bikle, Daniel D. Vitamin D and the skin. Journal of bone and mineral metabolism vol. 28,2 (2010): 117-30. DOI: 10.1007/s00774-009-0153-8

    Bikle, Daniel D. Vitamin D metabolism and function in the skin. Molecular and cellular endocrinology vol. 347,1-2 (2011): 80-9. DOI: 10.1016/j.mce.2011.05.017

    MacLaughlin, J, and M F Holick. Aging decreases the capacity of human skin to produce vitamin D3. The Journal of clinical investigation vol. 76,4 (1985): 1536-8. DOI: 10.1172/JCI112134

    Holick, M F et al. Photosynthesis of previtamin D3 in human skin and the physiologic consequences. Science (New York, N.Y.) vol. 210,4466 (1980): 203-5. DOI: 10.1126/science.6251551

    L-Lysine HCL & Vegan Omega-3            

    Baldwin, Hilary, and Jerry Tan. Effects of Diet on Acne and Its Response to Treatment. American journal of clinical dermatology, 10.1007/s40257-020-00542-y. 3 Aug. 2020. DOI: 10.1007/s40257-020-00542-y

    Kiefer, David, and Traci Pantuso. Omega-3 fatty acids: An update emphasizing clinical use. Agro food industry hi-tech vol. 23,4 (2012): 10-13. PMID: 24436723

    Huang, Tse-Hung et al. Cosmetic and Therapeutic Applications of Fish Oil's Fatty Acids on the Skin. Marine drugs vol. 16,8 256. 30 Jul. 2018. doi: 10.3390/md16080256

    Pilkington, Suzanne M et al. Omega-3 polyunsaturated fatty acids: photoprotective macronutrients. Experimental dermatology vol. 20,7 (2011): 537-43. DOI: 10.1111/j.1600-0625.2011.01294.x

    Tanghetti, Emil A. The role of inflammation in the pathology of acne. The Journal of clinical and aesthetic dermatology vol. 6,9 (2013): 27-35. PMID: 24062871

    Rubin, Mark G et al. Acne vulgaris, mental health and omega-3 fatty acids: a report of cases. Lipids in health and disease vol. 7 36. 13 Oct. 2008. doi: 10.1186/1476-511X-7-36

    Khayef, Golandam et al. Effects of fish oil supplementation on inflammatory acne. Lipids in health and disease vol. 11 165. 3 Dec. 2012. doi: 10.1186/1476-511X-11-165

    Jung, Jae Yoon et al. Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. Acta dermato-venereologica vol. 94,5 (2014): 521-5. DOI: 10.2340/00015555-1802

    Mirnezami, Mina, and Hoda Rahimi. Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects in Patients with Acne Vulgaris?. Dermatology research and practice vol. 2018 6974045. 29 May. 2018. doi: 10.1155/2018/6974045

    Neukam, K et al. Supplementation of flaxseed oil diminishes skin sensitivity and improves skin barrier function and condition. Skin pharmacology and physiology vol. 24,2 (2011): 67-74. DOI: 10.1159/000321442

    Yamauchi, Mitsuo, and Marnisa Sricholpech. Lysine post-translational modifications of collagen. Essays in biochemistry vol. 52 (2012): 113-33. doi: 10.1042/bse0520113

    Singh, Meenu & Rao, Dowlathabad & Pande, Shivansh & Battu, Sowjanya & Rajeswar Dutt, Kunduri & Ramesh, Mantri. (2011). Medicinal Uses of L-Lysine: Past and Future. International Journal of Research in Pharmaceutical Sciences. 2.

    Niacin, Riboflavin, Thiamin

    Walocko, Frances M et al. The role of nicotinamide in acne treatment. Dermatologic therapy vol. 30,5 (2017): 10.1111/dth.12481. DOI: 10.1111/dth.12481

    Levin, Jacquelyn, and Saira B Momin. How much do we really know about our favorite cosmeceutical ingredients?. The Journal of clinical and aesthetic dermatology vol. 3,2 (2010): 22-41. PMID: 20725560

    Bissett, Donald L et al. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] vol. 31,7 Pt 2 (2005): 860-5; discussion 865. DOI: 10.1111/j.1524-4725.2005.31732

    Matts, Paul & Oblong, John & Bissett, D.L.. (2002). A Review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag. 5. 285-289.

    Park, Sang Min et al. Niacin intake and risk of skin cancer in US women and men. International journal of cancer vol. 140,9 (2017): 2023-2031. doi: 10.1002/ijc.30630

    Mahabadi N, Bhusal A, Banks SW. Riboflavin Deficiency. [Updated 2020 Jul 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.

    Thakur, Kiran & Tomar, Sudhir & Singh, Ashish Kumar & Mandal, Surajit & Arora, Sumit. (2016). Riboflavin and health: A review of recent human research. Critical reviews in food science and nutrition. 57. DOI: 10.1080/10408398.2016.1145104

    Alvarez, O M, and R L Gilbreath. Thiamine influence on collagen during the granulation of skin wounds. The Journal of surgical research vol. 32,1 (1982): 24-31. DOI: 10.1016/0022-4804(82)90180-9

    Probiotic Blend

    Kober, Mary-Margaret, and Whitney P Bowe. The effect of probiotics on immune regulation, acne, and photoaging. International journal of women's dermatology vol. 1,2 85-89. 6 Apr. 2015, doi: 10.1016/j.ijwd.2015.02.001

    Lee, Young Bok et al. Potential Role of the Microbiome in Acne: A Comprehensive Review. Journal of clinical medicine vol. 8,7 987. 7 Jul. 2019. doi: 10.3390/jcm8070987

    Dolan, Keren E et al. Probiotics and Disease: A Comprehensive Summary-Part 6, Skin Health. Integrative medicine (Encinitas, Calif.) vol. 16,4 (2017): 32-41. PMID: 30881255

    Skin Herbals

    Vostálová, Jitka et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules (Basel, Switzerland) vol. 24,6 1022. 14 Mar. 2019. doi: 10.3390/molecules24061022

    Hung, Chi-feng et al. Topical delivery of silymarin constituents via the skin route. Acta pharmacologica Sinica vol. 31,1 (2010): 118-26. doi: 10.1038/aps.2009.186

    Dhanalakshmi, Sivanandhan et al. Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis vol. 25,8 (2004): 1459-65. DOI: 10.1093/carcin/bgh152

    Gunes, Seda et al. In vitro evaluation of Spirulina platensis extract incorporated skin cream with its wound healing and antioxidant activities. Pharmaceutical biology vol. 55,1 (2017): 1824-1832. doi:10.1080/13880209.2017.1331249

    Yang, Yafan, and Shuangshuang Li. Dandelion Extracts Protect Human Skin Fibroblasts from UVB Damage and Cellular Senescence. Oxidative medicine and cellular longevity vol. 2015 (2015): 619560. doi: 10.1155/2015/619560

    OyetakinWhite, Patricia et al. Protective mechanisms of green tea polyphenols in skin. Oxidative medicine and cellular longevity vol. 2012 (2012): 560682. doi: 10.1155/2012/560682

    Katiyar, S K et al. Green tea and skin. Archives of dermatology vol. 136,8 (2000): 989-94. DOI: 10.1001/archderm.136.8.989

    Clifford, Tom et al. The potential benefits of red beetroot supplementation in health and disease. Nutrients vol. 7,4 2801-22. 14 Apr. 2015. doi: 10.3390/nu7042801

    Albaugh, Vance L et al. Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing. The Journal of nutrition vol. 147,11 (2017): 2011-2017. doi: 10.3945/jn.117.256404

    Beitner, H. Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. The British journal of dermatology vol. 149,4 (2003): 841-9. DOI: 10.1046/j.1365-2133.2003.05597.x

    Oregon Health & Science University. "Pepper Compound Could Aid Millions With Vitiligo." ScienceDaily. ScienceDaily, 15 April 2008.

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