Vitamins & Minerals

Mrinal Gupta, Vikram K. Mahajan, Karaninder S. Mehta, Pushpinder S. Chauhan, "Zinc Therapy in Dermatology: A Review", Dermatology Research and Practice, vol. 2014, Article ID 709152, 11 pages, 2014. DOI: 10.1155/2014/709152

Brandt, Staci. “The clinical effects of zinc as a topical or oral agent on the clinical response and pathophysiologic mechanisms of acne: a systematic review of the literature.” Journal of drugs in dermatology : JDD vol. 12,5 (2013): 542-5. PMID: 23652948

Dreno, B et al. “Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris.” Dermatology (Basel, Switzerland) vol. 203,2 (2001): 135-40. DOI: 10.1159/000051728

Yee, Brittany E et al. “Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.” Dermatologic therapy, e14252. 29 Aug. 2020, DOI: 10.1111/dth.14252

Dhaliwal, Simran et al. “Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence.” American journal of clinical dermatology vol. 21,1 (2020): 21-39. DOI: 10.1007/s40257-019-00484-0

Ozuguz, Pinar et al. “Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris.” Cutaneous and ocular toxicology vol. 33,2 (2014): 99-102. DOI: 10.3109/15569527.2013.808656

Rostami Mogaddam, Majid et al. “Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris.” BioMed research international vol. 2014 (2014): 474108. DOI: 10.1155/2014/474108

Ikaraoha, C I et al. “The Role of Blood Lead, Cadmium, Zinc and Copper in Development and Severity of Acne Vulgaris in a Nigerian Population.” Biological trace element research vol. 176,2 (2017): 251-257. DOI: 10.1007/s12011-016-0839-4

Gupta, Mrinal et al. “Zinc therapy in dermatology: a review.” Dermatology research and practice vol. 2014 (2014): 709152. doi: 10.1155/2014/709152

Ogawa, Youichi et al. “Zinc and Skin Disorders.” Nutrients vol. 10,2 199. 11 Feb. 2018, doi: 10.3390/nu10020199

Keen, Mohammad Abid, and Iffat Hassan. “Vitamin E in dermatology.” Indian dermatology online journal vol. 7,4 (2016): 311-5. doi: 10.4103/2229-5178.185494

Nachbar, F, and H C Korting. “The role of vitamin E in normal and damaged skin.” Journal of molecular medicine (Berlin, Germany) vol. 73,1 (1995): 7-17. DOI: 10.1007/BF00203614

Schagen, Silke K et al. “Discovering the link between nutrition and skin aging.” Dermato-endocrinology vol. 4,3 (2012): 298-307. doi: 10.4161/derm.22876

Eberlein-König, B et al. “Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E).” Journal of the American Academy of Dermatology vol. 38,1 (1998): 45-8. DOI: 10.1016/s0190-9622(98)70537-7

Kafi, Reza et al. “Improvement of naturally aged skin with vitamin A (retinol).” Archives of dermatology vol. 143,5 (2007): 606-12. DOI: 10.1001/archderm.143.5.606

Zasada, Malwina, and Elżbieta Budzisz. “Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments.” Postepy dermatologii i alergologii vol. 36,4 (2019): 392-397. doi: 10.5114/ada.2019.87443

Mukherjee, Siddharth et al. “Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety.” Clinical interventions in aging vol. 1,4 (2006): 327-48. PMCID: PMC2699641

Telang, Pumori Saokar. “Vitamin C in dermatology.” Indian dermatology online journal vol. 4,2 (2013): 143-6. doi: 10.4103/2229-5178.110593

Pullar, Juliet M et al. “The Roles of Vitamin C in Skin Health.” Nutrients vol. 9,8 866. 12 Aug. 2017, doi: 10.3390/nu9080866

Rattanawiwatpong, Pattarawan et al. “Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial.” Journal of cosmetic dermatology vol. 19,3 (2020): 671-676. doi: 10.1111/jocd.13305

Umar, Meenakshi et al. “Vitamin D and the Pathophysiology of Inflammatory Skin Diseases.” Skin pharmacology and physiology vol. 31,2 (2018): 74-86. DOI: 10.1159/000485132

Mostafa, Wedad Z, and Rehab A Hegazy. “Vitamin D and the skin: Focus on a complex relationship: A review.” Journal of advanced research vol. 6,6 (2015): 793-804. doi: 10.1016/j.jare.2014.01.011

Sadat-Ali, Mir et al. “Topical delivery of vitamin d3: a randomized controlled pilot study.” International journal of biomedical science : IJBS vol. 10,1 (2014): 21-4. PMCID: PMC3976443

Weber, Günther et al. “Vitamin D induces the antimicrobial protein hCAP18 in human skin.” The Journal of investigative dermatology vol. 124,5 (2005): 1080-2. DOI: 10.1111/j.0022-202X.2005.23687.x

Bikle, Daniel D. “Vitamin D and the skin.” Journal of bone and mineral metabolism vol. 28,2 (2010): 117-30. DOI: 10.1007/s00774-009-0153-8

Bikle, Daniel D. “Vitamin D metabolism and function in the skin.” Molecular and cellular endocrinology vol. 347,1-2 (2011): 80-9. DOI: 10.1016/j.mce.2011.05.017

MacLaughlin, J, and M F Holick. “Aging decreases the capacity of human skin to produce vitamin D3.” The Journal of clinical investigation vol. 76,4 (1985): 1536-8. DOI: 10.1172/JCI112134

Holick, M F et al. “Photosynthesis of previtamin D3 in human skin and the physiologic consequences.” Science (New York, N.Y.) vol. 210,4466 (1980): 203-5. DOI: 10.1126/science.6251551

L-Lysine HCL & Vegan Omega-3            

Baldwin, Hilary, and Jerry Tan. “Effects of Diet on Acne and Its Response to Treatment.” American journal of clinical dermatology, 10.1007/s40257-020-00542-y. 3 Aug. 2020. DOI: 10.1007/s40257-020-00542-y

Kiefer, David, and Traci Pantuso. “Omega-3 fatty acids: An update emphasizing clinical use.” Agro food industry hi-tech vol. 23,4 (2012): 10-13. PMID: 24436723

Huang, Tse-Hung et al. “Cosmetic and Therapeutic Applications of Fish Oil's Fatty Acids on the Skin.” Marine drugs vol. 16,8 256. 30 Jul. 2018. doi: 10.3390/md16080256

Pilkington, Suzanne M et al. “Omega-3 polyunsaturated fatty acids: photoprotective macronutrients.” Experimental dermatology vol. 20,7 (2011): 537-43. DOI: 10.1111/j.1600-0625.2011.01294.x

Tanghetti, Emil A. “The role of inflammation in the pathology of acne.” The Journal of clinical and aesthetic dermatology vol. 6,9 (2013): 27-35. PMID: 24062871

Rubin, Mark G et al. “Acne vulgaris, mental health and omega-3 fatty acids: a report of cases.” Lipids in health and disease vol. 7 36. 13 Oct. 2008. doi: 10.1186/1476-511X-7-36

Khayef, Golandam et al. “Effects of fish oil supplementation on inflammatory acne.” Lipids in health and disease vol. 11 165. 3 Dec. 2012. doi: 10.1186/1476-511X-11-165

Jung, Jae Yoon et al. “Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial.” Acta dermato-venereologica vol. 94,5 (2014): 521-5. DOI: 10.2340/00015555-1802

Mirnezami, Mina, and Hoda Rahimi. “Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris?.” Dermatology research and practice vol. 2018 6974045. 29 May. 2018. doi: 10.1155/2018/6974045

Neukam, K et al. “Supplementation of flaxseed oil diminishes skin sensitivity and improves skin barrier function and condition.” Skin pharmacology and physiology vol. 24,2 (2011): 67-74. DOI: 10.1159/000321442

Yamauchi, Mitsuo, and Marnisa Sricholpech. “Lysine post-translational modifications of collagen.” Essays in biochemistry vol. 52 (2012): 113-33. doi: 10.1042/bse0520113

Singh, Meenu & Rao, Dowlathabad & Pande, Shivansh & Battu, Sowjanya & Rajeswar Dutt, Kunduri & Ramesh, Mantri. (2011). Medicinal Uses of L-Lysine: Past and Future. International Journal of Research in Pharmaceutical Sciences. 2.

Niacin, Riboflavin, Thiamin

Walocko, Frances M et al. “The role of nicotinamide in acne treatment.” Dermatologic therapy vol. 30,5 (2017): 10.1111/dth.12481. DOI: 10.1111/dth.12481

Levin, Jacquelyn, and Saira B Momin. “How much do we really know about our favorite cosmeceutical ingredients?.” The Journal of clinical and aesthetic dermatology vol. 3,2 (2010): 22-41. PMID: 20725560

Bissett, Donald L et al. “Niacinamide: A B vitamin that improves aging facial skin appearance.” Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] vol. 31,7 Pt 2 (2005): 860-5; discussion 865. DOI: 10.1111/j.1524-4725.2005.31732

Matts, Paul & Oblong, John & Bissett, D.L.. (2002). A Review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag. 5. 285-289.

Park, Sang Min et al. “Niacin intake and risk of skin cancer in US women and men.” International journal of cancer vol. 140,9 (2017): 2023-2031. doi: 10.1002/ijc.30630

Mahabadi N, Bhusal A, Banks SW. Riboflavin Deficiency. [Updated 2020 Jul 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.

Thakur, Kiran & Tomar, Sudhir & Singh, Ashish Kumar & Mandal, Surajit & Arora, Sumit. (2016). Riboflavin and health: A review of recent human research. Critical reviews in food science and nutrition. 57. DOI: 10.1080/10408398.2016.1145104

Alvarez, O M, and R L Gilbreath. “Thiamine influence on collagen during the granulation of skin wounds.” The Journal of surgical research vol. 32,1 (1982): 24-31. DOI: 10.1016/0022-4804(82)90180-9

Probiotic Blend

Kober, Mary-Margaret, and Whitney P Bowe. “The effect of probiotics on immune regulation, acne, and photoaging.” International journal of women's dermatology vol. 1,2 85-89. 6 Apr. 2015, doi: 10.1016/j.ijwd.2015.02.001

Lee, Young Bok et al. “Potential Role of the Microbiome in Acne: A Comprehensive Review.” Journal of clinical medicine vol. 8,7 987. 7 Jul. 2019. doi: 10.3390/jcm8070987

Dolan, Keren E et al. “Probiotics and Disease: A Comprehensive Summary-Part 6, Skin Health.” Integrative medicine (Encinitas, Calif.) vol. 16,4 (2017): 32-41. PMID: 30881255

Skin Herbals

Vostálová, Jitka et al. “Skin Protective Activity of Silymarin and its Flavonolignans.” Molecules (Basel, Switzerland) vol. 24,6 1022. 14 Mar. 2019. doi: 10.3390/molecules24061022

Hung, Chi-feng et al. “Topical delivery of silymarin constituents via the skin route.” Acta pharmacologica Sinica vol. 31,1 (2010): 118-26. doi: 10.1038/aps.2009.186

Dhanalakshmi, Sivanandhan et al. “Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis.” Carcinogenesis vol. 25,8 (2004): 1459-65. DOI: 10.1093/carcin/bgh152

Gunes, Seda et al. “In vitro evaluation of Spirulina platensis extract incorporated skin cream with its wound healing and antioxidant activities.” Pharmaceutical biology vol. 55,1 (2017): 1824-1832. doi:10.1080/13880209.2017.1331249

Yang, Yafan, and Shuangshuang Li. “Dandelion Extracts Protect Human Skin Fibroblasts from UVB Damage and Cellular Senescence.” Oxidative medicine and cellular longevity vol. 2015 (2015): 619560. doi: 10.1155/2015/619560

OyetakinWhite, Patricia et al. “Protective mechanisms of green tea polyphenols in skin.” Oxidative medicine and cellular longevity vol. 2012 (2012): 560682. doi: 10.1155/2012/560682

Katiyar, S K et al. “Green tea and skin.” Archives of dermatology vol. 136,8 (2000): 989-94. DOI: 10.1001/archderm.136.8.989

Clifford, Tom et al. “The potential benefits of red beetroot supplementation in health and disease.” Nutrients vol. 7,4 2801-22. 14 Apr. 2015. doi: 10.3390/nu7042801

Albaugh, Vance L et al. “Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing.” The Journal of nutrition vol. 147,11 (2017): 2011-2017. doi: 10.3945/jn.117.256404

Beitner, H. “Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin.” The British journal of dermatology vol. 149,4 (2003): 841-9. DOI: 10.1046/j.1365-2133.2003.05597.x

Oregon Health & Science University. "Pepper Compound Could Aid Millions With Vitiligo." ScienceDaily. ScienceDaily, 15 April 2008.