Ayurvedic Botanical Herbal Blend: Fermented Triphala Extract, Fermented Holy Basil Leaf Extract (Ocimum tenuiflorum), Raspberry Powder (Leaf), Fermented Fenugreek Seed Extract (Trigonella foenum-graecum), Bitter Fennel (Seed), Sage Herb Powder (Leaf), Cranberry Extract (Fruit), Red Clover (Flower), Probiotic Blend (50 Billion CFU‡): S. boulardii, B. coagulans, L. plantarum, L. paracasei, L. rhamnosus, L. casei, B. lactis, B. breve, B. bifidum, L acidophilus, L. fermentum, L. gasseri, L. helveticus, B. longum, L. johnsonii, L. crispatus, L. bulgaricus, B. subtilis. Other Ingredients: Methylcellulose Capsule, Enteric Coating.

‡At time of manufacture.

Take 2 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food. Not intended for children.

CAUTION: Do not exceed recommended dose. If you are allergic, or think you may be allergic to any of the listed ingredients, consult your primary healthcare physician before consuming. If you are pregnant, nursing, have a medical condition, or taking any medication, consult your doctor before using this product. If you experience an allergic reaction, please stop using the product immediately and contact your doctor. Do no exceed recommended dose. If your item appears to be damaged upon arrival, please contact us immediately. Additionally, if you experience any adverse reactions such as stomach pains, nausea, diarrhea, headache, rash, or others, please stop taking this product immediately and contact your doctor. Color and odor may vary from batch to batch. Contains no filler ingredients, artificial flavors, colors, sweeteners, or preservatives. Use this product as a food supplement only. Do not use for weight reduction.

Probiotic Blend

Reid G. (2017). The development of probiotics for women's health. Canadian journal of microbiology, 63(4), 269–277. DOI: 10.1139/cjm-2016-0733

Borges, S., Silva, J., & Teixeira, P. (2014). The role of lactobacilli and probiotics in maintaining vaginal health. Archives of gynecology and obstetrics, 289(3), 479–489. DOI: 10.1007/s00404-013-3064-9

Reid G. (2001). Probiotic agents to protect the urogenital tract against infection. The American journal of clinical nutrition, 73(2 Suppl), 437S–443S. DOI: 10.1093/ajcn/73.2.437s

Lepargneur J. P. (2016). Lactobacillus crispatus as biomarker of the healthy vaginal tract. Lactobacillus crispatus, biomarqueur de l'écosystème vaginal sain. Annales de biologie clinique, 74(4), 421–427. DOI: 10.1684/abc.2016.1169

Reid, G., & Bruce, A. W. (2001). Could probiotics be an option for treating and preventing urogenital infections?. Medscape women's health, 6(5), 9. PMID: 11698931

Kovachev S. (2018). Defence factors of vaginal lactobacilli. Critical reviews in microbiology, 44(1), 31–39. DOI: 10.1080/1040841X.2017.1306688

Rostok, M., Hütt, P., Rööp, T., Smidt, I., Štšepetova, J., Salumets, A., & Mändar, R. (2019). Potential vaginal probiotics: safety, tolerability and preliminary effectiveness. Beneficial microbes, 10(4), 385–393. DOI: 10.3920/BM2016.0123

Jacqueline A. McGroarty, Probiotic use of lactobacilli in the human female urogenital tract, FEMS Immunology & Medical Microbiology, Volume 6, Issue 4, April 1993, Pages 251–264. DOI: 10.1111/j.1574-695X.1993.tb00337.x

Reid, G., Dols, J., & Miller, W. (2009). Targeting the vaginal microbiota with probiotics as a means to counteract infections. Current opinion in clinical nutrition and metabolic care, 12(6), 583–587. DOI: 10.1097/MCO.0b013e328331b611

Akgül T, Karakan T. The role of probiotics in women with recurrent urinary tract infections. Turk J Urol. 2018;44(5):377‐383. doi: 10.5152/tud.2018.48742

Gupta, V., Nag, D., & Garg, P. (2017). Recurrent urinary tract infections in women: How promising is the use of probiotics?. Indian journal of medical microbiology, 35(3), 347–354. DOI: 10.4103/ijmm.IJMM_16_292

Falagas, M. E., Betsi, G. I., Tokas, T., & Athanasiou, S. (2006). Probiotics for prevention of recurrent urinary tract infections in women: a review of the evidence from microbiological and clinical studies. Drugs, 66(9), 1253–1261. DOI: 10.2165/00003495-200666090-00007

Fermented Prebiotic Fibers

Swain MR, Anandharaj M, Ray RC, Parveen Rani R. Fermented fruits and vegetables of Asia: a potential source of probiotics. Biotechnol Res Int. 2014;2014:250424. doi:10.1155/2014/250424

Dhiman K. Ayurvedic intervention in the management of uterine fibroids: A Case series. Ayu. 2014;35(3):303‐308. doi: 10.4103/0974-8520.153750

Smejkal, C., Kolida, S., Bingham, M., Gibson, G., & McCartney, A. (2003). Probiotics and prebiotics in female health. The journal of the British Menopause Society, 9(2), 69–74. DOI: 10.1258/136218003100322224

Martinez, R. C., Bedani, R., & Saad, S. M. (2015). Scientific evidence for health effects attributed to the consumption of probiotics and prebiotics: an update for current perspectives and future challenges. The British journal of nutrition, 114(12), 1993–2015. DOI: 10.1017/S0007114515003864

Roberfroid M. B. (2000). Prebiotics and probiotics: are they functional foods?. The American journal of clinical nutrition, 71(6 Suppl), 1682S–90S. DOI: 10.1093/ajcn/71.6.1682S

Quigley E. M. (2012). Prebiotics and probiotics: their role in the management of gastrointestinal disorders in adults. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 27(2), 195–200. DOI: 10.1177/0884533611423926

Bommer, S., Klein, P., & Suter, A. (2011). First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Advances in therapy, 28(6), 490–500. DOI: 10.1007/s12325-011-0027-z

Kargozar, R., Azizi, H., & Salari, R. (2017). A review of effective herbal medicines in controlling menopausal symptoms. Electronic physician, 9(11), 5826–5833. DOI: 10.19082/5826

Carlson JL, Erickson JM, Lloyd BB, Slavin JL. Health Effects and Sources of Prebiotic Dietary Fiber. Curr Dev Nutr. 2018;2(3):nzy005. Published 2018 Jan 29. doi: 10.1093/cdn/nzy005

Meyer D. (2015). Health benefits of prebiotic fibers. Advances in food and nutrition research, 74, 47–91. DOI: 10.1016/bs.afnr.2014.11.002

Jamshidi N, Cohen MM. The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. Evid Based Complement Alternat Med. 2017;2017:9217567. doi: 10.1155/2017/9217567

Khadivzadeh T, Najafi MN, Kargarfard L, Ghazanfarpour M, Dizavandi FR, Khorsand I. Effect of Fennel on the Health Status of Menopausal Women: A Systematic and Meta-analysis. J Menopausal Med. 2018;24(1):67‐74. doi: 10.6118/jmm.2018.24.1.67

Ehsanpour S, Salehi K, Zolfaghari B, Bakhtiari S. The effects of red clover on quality of life in post-menopausal women. Iran J Nurs Midwifery Res. 2012;17(1):34‐40. PMID: 23493172

Ghazanfarpour M, Sadeghi R, Latifnejad Roudsari R, et al. Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis. Avicenna J Phytomed. 2015;5(6):498‐511. PMID: 26693407

Botanical Herbs

Steels, E., Steele, M. L., Harold, M., & Coulson, S. (2017). Efficacy of a Proprietary Trigonella foenum-graecum L. De-Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Study. Phytotherapy research : PTR, 31(9), 1316–1322. DOI: 10.1002/ptr.5856

Shamshad Begum, S., Jayalakshmi, H. K., Vidyavathi, H. G., Gopakumar, G., Abin, I., Balu, M., Geetha, K., Suresha, S. V., Vasundhara, M., & Krishnakumar, I. M. (2016). A Novel Extract of Fenugreek Husk (FenuSMART™) Alleviates Postmenopausal Symptoms and Helps to Establish the Hormonal Balance: A Randomized, Double-Blind, Placebo-Controlled Study. Phytotherapy research : PTR, 30(11), 1775–1784. DOI: 10.1002/ptr.5680

Nagulapalli Venkata, K. C., Swaroop, A., Bagchi, D., & Bishayee, A. (2017). A small plant with big benefits: Fenugreek (Trigonella foenum-graecum Linn.) for disease prevention and health promotion. Molecular nutrition & food research, 61(6). DOI: 10.1002/mnfr.201600950

Rao, A., Steels, E., Beccaria, G., Inder, W. J., & Vitetta, L. (2015). Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study. Phytotherapy research : PTR, 29(8), 1123–1130. DOI: 10.1002/ptr.5355

Rao, A., Steels, E., Inder, W. J., Abraham, S., & Vitetta, L. (2016). Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study. The aging male : the official journal of the International Society for the Study of the Aging Male, 19(2), 134–142. DOI: 10.3109/13685538.2015.1135323

Yadav, U. C., & Baquer, N. Z. (2014). Pharmacological effects of Trigonella foenum-graecum L. in health and disease. Pharmaceutical biology, 52(2), 243–254. DOI: 10.3109/13880209.2013.826247

Cranberry

Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2012;10(10):CD001321. Published 2012 Oct 17. doi: 10.1002/14651858.CD001321.pub5

Lavigne, J. P., Bourg, G., Botto, H., & Sotto, A. (2007). Cranberry (Vaccinium macrocarpon) et infections urinaires: étude et revue de la littérature [Cranberry (Vaccinium macrocarpon) and urinary tract infections: study model and review of literature]. Pathologie-biologie, 55(8-9), 460–464. https://doi.org/10.1016/j.patbio.2007.07.005

Howell A. B. (2007). Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Molecular nutrition & food research, 51(6), 732–737. DOI: 10.1002/mnfr.200700038

Howell, A. B., Reed, J. D., Krueger, C. G., Winterbottom, R., Cunningham, D. G., & Leahy, M. (2005). A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry, 66(18), 2281–2291. DOI: 10.1016/j.phytochem.2005.05.022

Raz, R., Chazan, B., & Dan, M. (2004). Cranberry juice and urinary tract infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 38(10), 1413–1419. DOI: 10.1086/386328

Howell A. B. (2002). Cranberry proanthocyanidins and the maintenance of urinary tract health. Critical reviews in food science and nutrition, 42(3 Suppl), 273–278. DOI: 10.1080/10408390209351915

Pérez-López, F. R., Haya, J., & Chedraui, P. (2009). Vaccinium macrocarpon: an interesting option for women with recurrent urinary tract infections and other health benefits. The journal of obstetrics and gynaecology research, 35(4), 630–639. DOI: 10.1111/j.1447-0756.2009.01026.x

Philip N, Walsh LJ. Cranberry Polyphenols: Natural Weapons against Dental Caries. Dent J (Basel). 2019;7(1):20. Published 2019 Mar 1. doi: 10.3390/dj7010020

Bonifait, L., & Grenier, D. (2010). Cranberry polyphenols: potential benefits for dental caries and periodontal disease. Journal (Canadian Dental Association), 76, a130. PMID: 20943032

Jeffrey B Blumberg, Arpita Basu, Christian G Krueger, Mary Ann Lila, Catherine C Neto, Janet A Novotny, Jess D Reed, Ana Rodriguez-Mateos, Cheryl D Toner, Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015, Advances in Nutrition, Volume 7, Issue 4, July 2016, Pages 759S–770S. DOI: 10.3945/an.116.012583

Zhao, S., Liu, H., & Gu, L. (2018). American cranberries and health benefits - an evolving story of 25 years. Journal of the science of food and agriculture, 10.1002/jsfa.8882. Advance online publication. DOI: 10.1002/jsfa.8882

Zhao, S., Liu, H., & Gu, L. (2018). American cranberries and health benefits - an evolving story of 25 years. Journal of the science of food and agriculture, 10.1002/jsfa.8882. Advance online publication. DOI: 10.1002/jsfa.8882

Hisano M, Bruschini H, Nicodemo AC, Srougi M. Cranberries and lower urinary tract infection prevention. Clinics (Sao Paulo). 2012;67(6):661‐668. doi: 10.6061/clinics/2012(06)18

Raspberry Leaf

Burton-Freeman BM, Sandhu AK, Edirisinghe I. Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links. Adv Nutr. 2016;7(1):44‐65. Published 2016 Jan 15. doi: 10.3945/an.115.009639

Basu A, Rhone M, Lyons TJ. Berries: emerging impact on cardiovascular health. Nutr Rev. 2010;68(3):168‐177. doi: 10.1111/j.1753-4887.2010.00273.x

Simpson, M., Parsons, M., Greenwood, J., & Wade, K. (2001). Raspberry leaf in pregnancy: its safety and efficacy in labor. Journal of midwifery & women's health, 46(2), 51–59. DOI: 10.1016/s1526-9523(01)00095-2

Parsons, M., Simpson, M., & Ponton, T. (1999). Raspberry leaf and its effect on labour: safety and efficacy. Australian College of Midwives Incorporated journal, 12(3), 20–25. DOI: 10.1016/s1031-170x(99)80008-7

Wang, S. Y., & Lin, H. S. (2000). Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. Journal of agricultural and food chemistry, 48(2), 140–146. DOI: 10.1021/jf9908345

Ferlemi AV, Lamari FN. Berry Leaves: An Alternative Source of Bioactive Natural Products of Nutritional and Medicinal Value. Antioxidants (Basel). 2016;5(2):17. Published 2016 Jun 1. doi: 10.3390/antiox5020017

Gruber CW, O'Brien M. Uterotonic plants and their bioactive constituents. Planta Med. 2011;77(3):207‐220. doi: 10.1055/s-0030-1250317