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Liposomal NAD+ & Betaine Anhydrous: The Formulation Logic

Liposomal NAD+ Case Study | Codeage Education
The Longevity Code · Pillar 03 · Cellular Longevity
Education · NAD+ & Cellular Energy

Liposomal NAD+
The Coenzyme of Cellular Life

500mg
NAD+ Per Serving
2
Active Compounds
30
Servings Per Container
9 min read·Cellular Longevity·Liposomal Delivery
Pillar Overview
03
Cellular Longevity
The Longevity Code

Energy is not metaphorical. It is molecular.

Every cell in the human body is understood to depend on a coenzyme called NAD+ to help convert nutrients into usable energy. Research suggests it may participate in hundreds of enzymatic reactions — from DNA maintenance to mitochondrial function to the regulation of circadian rhythm.

Codeage Liposomal NAD+ delivers 500mg of nicotinamide adenine dinucleotide per serving alongside betaine anhydrous — in a liposomal capsule format designed to support the cellular dimension of longevity. Pillar 03 of The Longevity Code addresses the body at the level where aging is understood to begin: the cell.

The Coenzyme Architecture

NAD+ is believed to participate in hundreds of enzymatic reactions in the human body.

It is not a vitamin. It is not a mineral. It is a coenzyme — a molecule that enzymes are understood to require in order to function. Research suggests that NAD+ availability may play a role in the efficiency of these cellular processes.

Pathway 01

Cellular Energy

NAD+ is understood to play an essential role in the metabolic pathways that help convert nutrients into ATP — the energy currency every cell depends on.

Pathway 02

DNA Maintenance

Enzymes that participate in DNA repair — including PARPs — are understood to require NAD+ as a substrate. Research suggests DNA integrity may depend on its availability.

Pathway 03

Sirtuin Activity

Sirtuins — a family of proteins studied for their potential role in cellular stress response and gene regulation — are NAD+-dependent enzymes.

Pathway 04

Circadian Regulation

Research suggests NAD+ levels may oscillate with the circadian cycle. The body's internal clock and NAD+ metabolism appear to be biochemically linked.

Two compounds. Each with a purpose.

This is not a complex stack. It is a focused formula — two compounds chosen for their direct relationship to NAD+ biology, delivered in a format designed to protect them through digestion.

NAD+
500mg · Nicotinamide Adenine Dinucleotide

The Coenzyme Itself

Not a precursor. Not a metabolic intermediate. This formula delivers NAD+ directly — the finished coenzyme, in its active form. 500mg per serving, encapsulated in a liposomal delivery system designed to help protect the molecule through the digestive environment and support its absorption.

TMG
102.5mg · Betaine Anhydrous (Trimethylglycine)

The Methyl Donor

Betaine anhydrous — also known as trimethylglycine — is a naturally occurring methyl donor. Methyl groups are understood to participate in a wide range of biochemical reactions, including those related to homocysteine metabolism. Its inclusion alongside NAD+ reflects a considered formulation pairing.

Codeage Helix Liposomal Delivery
500
mg NAD+ · Liposomal
Per Serving · 2 Capsules

Liposomal delivery is a method of encapsulating active compounds within phospholipid layers. The Codeage Helix Liposomal system uses phospholipids derived from non-GMO sunflower lecithin, including phosphatidylcholine, to encapsulate the NAD+ molecule. This delivery format has been the subject of growing interest in nutritional science as an approach to supplement delivery.

What the literature has explored.

Two areas of published research relevant to the formulation logic of this product — shared as educational context only.

Published Research Reference · NAD+ and Cellular Metabolism
"Research into NAD+ biology has examined the coenzyme's central role in mitochondrial electron transport, sirtuin-mediated gene regulation, and PARP-dependent DNA repair — identifying NAD+ decline as a feature of aging that intersects with multiple metabolic and cellular maintenance pathways."
For reference: Verdin, E. (2015). NAD⁺ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208–1213
Published Research Reference · Liposomal Delivery Systems
"Investigations into liposomal encapsulation have examined how phospholipid vesicles may interact with bioactive compounds in the gastrointestinal tract — a delivery approach that has been the subject of research across nutritional science applications."
For reference: Akbarzadeh, A., et al. (2013). Liposome: classification, preparation, and applications. Nanoscale Research Letters, 8(1), 102

The studies referenced above were conducted independently and did not involve this product. They are cited here solely for educational context regarding the ingredients or compound classes discussed, and do not represent claims about the intended effects of this formula.

A coenzyme present in every living cell.

NAD+ is not localized to a single organ or tissue. It is present in every cell that performs metabolic work — which is every cell. Its relevance spans the entire body.

Mitochondria

The electron transport chain — the final stage of cellular energy production — is understood to require NAD+ to function. Every cell with mitochondria may depend on its availability.

Cell Nucleus

NAD+ is understood to be consumed by PARP enzymes and sirtuins in the nucleus — both studied for their involvement in DNA maintenance and gene regulation processes.

Brain & Neurons

Neurons are among the most metabolically active cells in the body. Their energy demands are understood to place a significant requirement on NAD+ availability.

Muscle Tissue

Skeletal and cardiac muscle are understood to depend on NAD+ for the metabolic processes that may support contraction, repair, and energy production during physical activity.

Liver

The liver — the body's primary metabolic organ — is understood to maintain high concentrations of NAD+ to help support detoxification, lipid metabolism, and glucose regulation.

The capsule format is a formulation decision.

Delivering 500mg of liposomal NAD+ alongside betaine anhydrous in a daily capsule format reflects the specific considerations of the compound — its delivery format, dosing, and suitability for daily use.

500
NAD+ Per Serving

A meaningful daily dose.

500mg of nicotinamide adenine dinucleotide per two-capsule serving — a dose that reflects the emerging research interest in NAD+ supplementation at substantive levels.

30
Servings Per Container

One month of daily use.

60 capsules per bottle. Two capsules per serving. Designed for a full month of consistent daily supplementation — a timeframe that may reflect how longevity compounds are commonly studied.

Liposomal Encapsulation

Phospholipid protection.

The Codeage Helix Liposomal system wraps the active compound in phospholipid layers from non-GMO sunflower lecithin — designed to help protect NAD+ through the digestive process.

⦿
Methylcellulose Capsule

Plant-based delivery.

The capsule shell is methylcellulose — a plant-derived material. No gelatin. No animal-derived capsule components. Compatible with a broader range of dietary preferences.

The Longevity Code · Architecture

The cellular layer
of a life well-maintained.

Pillar 03 of The Longevity Code addresses longevity where it is understood to begin — at the level of the cell. NAD+, mitochondrial function, DNA maintenance. The molecular infrastructure that may support everything else.

01 · Daily Foundation 02 · Structural Integrity 03 · Cellular Longevity 04 · Systemic Balance

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