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Liposomal
NRHM+
Nicotinamide Riboside Hydrogen Malate, Trans-Resveratrol, D-Ribose, and Quercetin — a precision formula studied in the context of cellular biology, delivered via the Codeage Helix Liposomal system.
The Cellular Context
NAD+ research and the compounds science has studied alongside it.
Within every cell in the human body, a coenzyme called NAD+ is involved in energy metabolism, DNA repair signaling, and the activity of proteins known as sirtuins — widely studied in aging biology. Researchers have documented that NAD+ levels decline with age. Nicotinamide Riboside (NR) is one of the most studied NAD+ precursors, capable of crossing cell membranes to participate in NAD+ biosynthesis pathways.
Liposomal NRHM+ maps to Pillar 03 — Cellular Longevity. Pillar 03 is built around precision compounds — ingredients researchers have studied in the context of cellular aging mechanisms, NAD+ biology, and the molecular processes associated with how cells age over time.
The Science Foundation
Understanding Nicotinamide Riboside
Before the formula, the mechanism. NR occupies a specific and well-studied position in the NAD+ biosynthesis pathway — distinct from other precursors in how it is processed by the body.
Nicotinamide Riboside (NR)
NR is a nucleoside — a form of vitamin B3 — that enters the NAD+ biosynthesis pathway via the Preiss-Handler and salvage pathways. Unlike niacin or nicotinamide, NR can be phosphorylated directly to NMN by NR kinases (NRK1, NRK2) before converting to NAD+. This distinct entry point has made NR one of the primary subjects of NAD+ precursor research, particularly in studies examining aging biology and metabolic function.
Hydrogen Malate Form (NRHM)
The Hydrogen Malate salt form of Nicotinamide Riboside — used in Liposomal NRHM+ — is associated with superior stability compared to the chloride salt (NR-Cl) form. Malate, derived from malic acid (a compound found naturally in the Krebs cycle), pairs with NR to form a more stable molecular structure. This formulation approach has drawn attention from researchers and formulators interested in studying how different NR salt forms behave in the context of cellular biology.
Formula Breakdown
Every ingredient. Every dose. Every reason.
Each compound in Liposomal NRHM+ is a subject of active cellular longevity research. The following explores the science behind each ingredient.
Nicotinamide Riboside Hydrogen Malate
The NR Hydrogen Malate in this formula represents the primary active compound. NR has been studied extensively as a direct precursor to NAD+ — a coenzyme whose decline with age has been documented across multiple human and animal studies. Research has examined NR's relationship with blood NAD+ levels in human subjects, its tissue distribution across liver, muscle, and brain, and its studied relationship with sirtuin proteins (SIRT1, SIRT3) — proteins widely investigated in metabolic regulation and cellular stress response research.
↗ Trammell et al., Nature Communications (2016) — NR and human blood NAD+ metabolomeJapanese Knotweed Extract — 98% Trans-Resveratrol
Trans-Resveratrol is the bioactive stilbene compound extracted from Polygonum cuspidatum root at a standardization rate of 98% — among the highest-purity forms used in cellular longevity research. Resveratrol's studied relationship with SIRT1 — a NAD+-dependent deacetylase — has positioned it as a natural companion in NAD+ pathway research. Studies have examined its associations with the AMPK/SIRT1 pathway, mitochondrial biogenesis, and inflammatory signaling markers in the context of biological aging. At 100mg standardized to 98% Trans-Resveratrol, this dose is consistent with parameters used in published research.
↗ Lagouge et al., Cell (2006) — Resveratrol, SIRT1, and mitochondrial researchD-Ribose
D-Ribose is a five-carbon (pentose) sugar that serves as the structural backbone of ATP (adenosine triphosphate) — the cell's primary energy currency — and of RNA. As a direct participant in the ribose-5-phosphate pathway, it is involved in nucleotide synthesis and cellular energy recycling. In cellular longevity research, D-Ribose has been examined in relation to energy substrate availability and mitochondrial function, particularly in metabolically active tissues such as cardiac and skeletal muscle. Its inclusion alongside NR reflects a formula designed to address both the NAD+ axis and the ATP substrate axis of cellular energy biology as studied in the research literature.
Quercetin Dihydrate
Quercetin is a flavonoid — a class of polyphenolic compounds found widely in the plant kingdom — sourced here from Sophora japonica buds in its dihydrate form for improved stability. Quercetin has attracted research attention in longevity biology for its studied associations with senolytic activity (investigating the relationship between this class of compound and senescent "zombie" cells that accumulate with aging) and SIRT1 signaling. At 25mg, its inclusion in this formula is designed to complement NR and resveratrol as part of a research-informed multi-pathway cellular longevity approach.
Vitamin C (as Ascorbic Acid)
Vitamin C as ascorbic acid is included as an antioxidant cofactor with its own established position in cellular biology research. Ascorbic acid is involved in enzymatic reactions studied in relation to collagen biosynthesis and carnitine production — biochemical processes that intersect with the broader metabolic contexts in which NR and resveratrol research also takes place.
Magnesium (as Citrate & Oxide)
Magnesium is one of the most studied essential minerals in human physiology, participating in over 300 enzymatic reactions including those involved in ATP production, DNA synthesis, and protein biosynthesis. Its inclusion in this formula is notable given the direct relationship researchers have documented between magnesium and NAD+ metabolism — magnesium serves as a required cofactor for the kinase enzymes involved in NR phosphorylation. The dual-form approach (citrate and oxide) reflects formulation considerations around both solubility and elemental density that are commonly examined in mineral bioavailability research.
Zinc (as Zinc Gluconate)
Zinc is an essential trace mineral studied extensively in the context of immune function, cellular signaling, and DNA repair mechanisms — areas that overlap significantly with the cellular longevity research landscape this formula inhabits. Zinc gluconate is among the most studied organic zinc forms in the nutritional science literature, examined for its studied relationship with absorption compared to inorganic zinc salts. Its presence in a cellular longevity formula reflects the broader research context in which adequate zinc status is considered a meaningful variable in aging biology.
Codeage Helix Technology
Liposomal delivery.
A studied approach to form.
Delivery format is a meaningful variable in supplement research. The Codeage Helix Liposomal Delivery system is built around phospholipid encapsulation technology — one of the most studied delivery formats in the nutritional science literature.
Phospholipid Encapsulation
Phospholipids sourced from non-GMO sunflower lecithin — including phosphatidylcholine — form a bilayer membrane around active compounds, sharing structural characteristics with cell membranes. This is the same general technology studied across liposomal delivery research.
GI Environment Consideration
Standard NR may be subject to degradation in the GI tract before reaching target tissues. Liposomal encapsulation is a delivery format studied in the context of how compounds may be protected through the digestive environment, and is among the approaches researchers have examined for sensitive actives.
Cellular Membrane Affinity
Because liposomes share structural characteristics with cell membranes, researchers have studied their potential for cellular membrane interaction — a property that has positioned liposomal delivery as a meaningful area of investigation in nutritional science and pharmacokinetics.
The Formula Architecture
Why these four compounds together.
Each ingredient was selected for its studied relationship to adjacent compounds in the NAD+ and cellular energy biology research landscape.
NR + Resveratrol — The SIRT1 Context
NR is studied as a precursor to cellular NAD+. Resveratrol has been studied in relation to SIRT1 — a NAD+-dependent enzyme. Researchers examining this combination have noted that the two compounds may have a complementary studied relationship: NR in the context of the substrate NAD+ requires to function, and resveratrol in the context of SIRT1 activity that NAD+ is associated with. This pairing is among the most examined in cellular longevity supplement research.
D-Ribose — The Energy Substrate Context
While NR is studied in relation to the NAD+ axis, D-Ribose has been examined in relation to ATP synthesis — a parallel but distinct dimension of cellular energy biology. Mitochondrial function is studied in relation to both adequate NAD+ for the electron transport chain and adequate nucleotide substrates for ATP production. D-Ribose represents a structural approach to this second research axis.
Quercetin — The Cellular Clearance Context
Cellular senescence — the studied accumulation of dysfunctional cells that cease dividing but remain metabolically active — is a recognized area of biological aging research. Quercetin's studied role in senolytic biology research adds a third dimension to this formula that neither NR nor resveratrol addresses directly, making the compound combination more architecturally complete from a research standpoint.
Serving Size — 1 Capsule
Liposomal NRHM+ delivers its complete formula in a single daily capsule. The liposomal encapsulation system allows for a precision dose in a compact form — because delivery format, not capsule count, is the relevant variable when evaluating a precision longevity formula.
The Research Context
What science has studied
about NR and the NAD+ pathway.
The following are independent peer-reviewed studies on the ingredient categories present in this formula. These studies do not represent research on this specific product.
Nicotinamide Riboside Supplementation and NAD+ Metabolism in Healthy Adults
A randomized, double-blind, placebo-controlled crossover study published in Nature Communications (2016) administered 100mg, 300mg, and 1,000mg of Nicotinamide Riboside to healthy adults and measured blood NAD+ metabolome responses. The study documented that NR supplementation was associated with a dose-dependent increase in blood NAD+ and related metabolites — among the first human evidence examining how NR may influence circulating NAD+ levels. The researchers also tracked the downstream metabolites NMN and NAM, mapping NR's full metabolic trajectory in human subjects.
↗ Trammell et al., Nature Communications (2016)Resveratrol, Mitochondrial Function, and SIRT1/PGC-1α Signaling — A Research Examination
Published in Cell (2006), this study examined resveratrol's studied associations with SIRT1 activation and downstream mitochondrial biogenesis in a murine model. The research found associations between resveratrol treatment and increased mitochondrial number and function, improved aerobic capacity, and extended lifespan in high-fat-diet mice — effects the authors associated primarily with SIRT1 and PGC-1α activity. This study is among the most cited in resveratrol research and helped establish the compound's position in NAD+-pathway longevity science, given SIRT1's documented dependence on NAD+ as a cofactor.
↗ Lagouge et al., Cell (2006)Cellular Longevity · Pillar 03
Precision compounds.
Studied with intention.
Liposomal NRHM+ is formulated for those who approach their biology the way they approach everything else — with precision, intention, and attention to the research.
Explore Liposomal NRHM+ →Educational content only. The studies cited are independent research and do not represent endorsement by the researchers of any specific product. Consult with a qualified healthcare professional before beginning any supplementation program, particularly if you are pregnant, nursing, taking medications, or have a medical condition.
