Vitamin C (from Acerola Cherry Extract), Proprietary Blend: Fermented Indian Frankincense Resin Extract (Boswellia serrata), Camu Camu Powder (Myrciaria dubia; Fruit), Fermented Triphala Extract (Amla Fruit Extract), Fermented Holy Basil Extract (Ocimum tenuiflorum; Leaf), Fermented Elecampane Extract (Root), Fermented Fenugreek Extract (Seed), Fermented Asparagus (Shoot), Mangosteen Powder (Garcinia mangostana; Fruit), Açaí Powder (Euterpe oleracea; Berry), Huang Qi Extract (Astragalus propinquus; Root), Ginger Extract (Root), White Peony Extract Root, Rose Hip Fruit Extract; Probiotic Blend (50 Billion CFU‡): S. boulardii, B. coagulans, L plantarum, L. paracasei, L. rhamnosus, L. casei,  B. lactis, B. breve, B. bifidum, L. acidophilus, L. fermentum, L. gasseri, L. helveticus, B.longum, L. johnsonii, L. crispatus, L. bulgaricus, B. subtilis, B. clausii; Phytoceramides. Other Ingredients: Enteric Coating, Methylcellulose Capsule.

‡At time of manufacture.

Adults take two capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.

Probiotic Blend

Verna EC, Lucak S. Use of probiotics in gastrointestinal disorders: what to recommend?. Therap Adv Gastroenterol. 2010;3(5):307‐319. doi: 10.1177/1756283X10373814

Ritchie, Marina & Romanuk, Tamara. (2012). A Meta-Analysis of Probiotic Efficacy for Gastrointestinal Diseases. PloS one. 7. e34938. DOI: 10.1371/journal.pone.0034938

Nancy Toedter Williams, Pharm.D., BCPS, BCNSP, Probiotics, American Journal of Health-System Pharmacy, Volume 67, Issue 6, 15 March 2010, Pages 449–458. DOI: 10.2146/ajhp090168

Salem I, Ramser A, Isham N, Ghannoum MA. The Gut Microbiome as a Major Regulator of the Gut-Skin Axis. Front Microbiol. 2018;9:1459. Published 2018 Jul 10. doi: 10.3389/fmicb.2018.01459

Ellis SR, Nguyen M, Vaughn AR, et al. The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions. Microorganisms. 2019;7(11):550. Published 2019 Nov 11. doi: 10.3390/microorganisms7110550

Szántó, M, Dózsa, A, Antal, D, Szabó, K, Kemény, L, Bai, P. Targeting the gut‐skin axis—Probiotics as new tools for skin disorder management? Exp Dermatol. 2019; 28: 1210– 1218. DOI: 10.1111/exd.14016 

M. Rahmati Roudsari, R. Karimi, S. Sohrabvandi & A. M. Mortazavian (2015) Health Effects of Probiotics on the Skin, Critical Reviews in Food Science and Nutrition, 55:9, 1219-1240, DOI: 10.1080/10408398.2012.680078

Fermented Prebiotic Fibers

Patel S, Goyal A. The current trends and future perspectives of prebiotics research: a review. 3 Biotech. 2012;2(2):115‐125. doi: 10.1007/s13205-012-0044-x

Thompson RS, Roller R, Mika A, Greenwood BN, Knight R, Chichlowski M, Berg BM and Fleshner M (2017) Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity. Front. Behav. Neurosci. 10:240. doi: 10.3389/fnbeh.2016.00240

Pham VT, Seifert N, Richard N, et al. The effects of fermentation products of prebiotic fibres on gut barrier and immune functions in vitro [published correction appears in PeerJ. 2018 Aug 17;6:. Steinert, Robert [corrected to Steinert, Robert E]]. PeerJ. 2018;6:e5288. Published 2018 Aug 10. doi:10.7717/peerj.5288

Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients. 2013;5(4):1417‐1435. Published 2013 Apr 22. doi: 10.3390/nu5041417

Poeker, S.A., Geirnaert, A., Berchtold, L. et al. Understanding the prebiotic potential of different dietary fibers using an in vitro continuous adult fermentation model (PolyFermS). Sci Rep 8, 4318 (2018). DOI: 10.1038/s41598-018-22438-y

Fermented Botanical Blend

Mohd Ali N, Yeap SK, Ho WY, Beh BK, Tan SW, Tan SG. The promising future of chia, Salvia hispanica L. J Biomed Biotechnol. 2012;2012:171956. doi: 10.1155/2012/171956

Ullah R, Nadeem M, Khalique A, et al. Nutritional and therapeutic perspectives of Chia (Salvia hispanica L.): a review. J Food Sci Technol. 2016;53(4):1750‐1758. doi: 10.1007/s13197-015-1967-0

Neri Numa, Iramaia & Sancho, Renata & Pereira, Ana Paula & Pastore, Gláucia. (2017). Small Brazilian wild fruits: Nutrients, bioactive compounds, health-promotion properties and commercial interest. Food Research International. 103. DOI: 10.1016/j.foodres.2017.10.053

Stallings AF, Lupo MP. Practical uses of botanicals in skin care. J Clin Aesthet Dermatol. 2009;2(1):36‐40.

Traditional Chinese Medicinal Herbs

Shenefelt PD. Herbal Treatment for Dermatologic Disorders. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 18. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92761/

Tirant M, Lotti T, Gianfaldoni S, Tchernev G, Wollina U, Bayer P. Integrative Dermatology - The Use of Herbals and Nutritional Supplements to Treat Dermatological Conditions. Open Access Maced J Med Sci. 2018;6(1):185‐202. Published 2018 Jan 21. doi: 10.3889/oamjms.2018.041

Bedi, Monica & Shenefelt, Philip. (2002). Herbal Therapy in Dermatology. Archives of dermatology. 138. 232-42. DOI: 10.1001/archderm.138.2.232

Botanicals in Dermatology and Skin Health. Juliane Reuter, Irmgard Merfort, Ute Wölfle, Günter Seelinger, and Christoph M. Schempp. Botanical Medicine. January 2009, 33-65

Alan M Dattner, Herbal and complementary medicine in dermatology. Dermatologic Clinics, 22, 3, 2004, 325-332, 0733-8635. DOI: 10.1016/j.det.2004.03.005

Vitamin C

Prakash A, Baskaran R. Acerola, an untapped functional superfruit: a review on latest frontiers. J Food Sci Technol. 2018;55(9):3373‐3384. doi: 10.1007/s13197-018-3309-5

Mezadri, Tatiana & Pachón, María-Soledad & Villaño, Débora & Garcia-Parrilla, María & Troncoso, Ana. (2006). The Acerola fruit: composition, productive characteristics and economic importance. Archivos latinoamericanos de nutrición. 56. 101-9.

Mingfeng Xu, Chenjia Shen, Han Zheng, Yunsheng Xu, Changfeng Xue, Beiwei Zhu, Jiangning Hu. Metabolomic analysis of acerola cherry (Malpighia emarginata) fruit during ripening development via UPLC-Q-TOF and contribution to the antioxidant activity. Food Research International, 130, 2020, 108915, 0963-9969. DOI: 10.1016/j.foodres.2019.108915

Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017;9(8):866. Published 2017 Aug 12. doi: 10.3390/nu9080866

Telang PS. Vitamin C in dermatology. Indian Dermatol Online J. 2013;4(2):143‐146. doi: 10.4103/2229-5178.110593

Al-Niaimi F, Chiang NYZ. Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. J Clin Aesthet Dermatol. 2017;10(7):14‐17.