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- 3,000 mg of grass-fed bone per serving
- Made from grass-fed, grass-finished, pasture-raised beef from Argentina
- Freeze dried, non-defatted, and desiccated
- Bone Matrix, cartilage & raw whole bone marrow
- Whole bone extracts can contain a source of specialized cells, collagen, growth factors, fat-soluble activators, trace minerals, and glycosaminoglycans*
- Non-GMO
- Gluten and hormones free
- Free of binders or flow agents
- 1-month supply
- Easy-to-use capsules
- Manufactured in the USA in a cGMP-certified facility
- Third-party tested
Description
Product Details
Featured Ingredients
Vitamin A
A fat-soluble vitamin
Vitamin B12
water-soluble vitamin known as cobalamin
Iron
An important mineral
Conjugated Linoleic Acid (CLA)
A fatty acid found in meat
Biotin
Known as vitamin B7 or H
Superfood
Grass-fed Argentinian beef bone marrow supplement is made with bovine bone marrow, bone matrix, and cartilage to provide nutrients and vitamins found in the bone.*
Suggested use
Adults take 6 capsules daily as directed by a healthcare professional with 8 ounces of water or your favorite beverage. May be taken with or without food.
See caution
CAUTION: Do not exceed recommended dose. Pregnant, nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Please use caution if you have allergies or sensitivities to any of the listed ingredients. Keep out of reach of children and pets. Do not use if safety seal is damaged or missing. Store in a cool dry place. Use this product as a food supplement only. Do not use for weight reduction.
Additional Details
Superfood
Grass-fed Argentinian beef bone marrow supplement is made with bovine bone marrow, bone matrix, and cartilage to provide nutrients and vitamins found in the bone.*
See all ingredients
Ingredients:
Grass-Fed Bone Extract (Bovine; Bone Matrix, Marrow & Cartilage) (BSE-free). Other Ingredients: Methylcellulose Capsule.
Pairs With
References
Adam, M., Musilova, J., Krabcova, M., Brettschneider, I., Pesakova, V., & Deyl, Z. (1980). Effect of cartilage bone marrow extract on the metabolism of collagen in osteoarthrotic cartilage. Pharmacology, 21(1), 53–58. DOI: 10.1159/000137415
Zhong, Z., Wheeler, M. D., Li, X., Froh, M., Schemmer, P., Yin, M., Bunzendaul, H., Bradford, B., & Lemasters, J. J. (2003). L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 6(2), 229–240. DOI: 10.1097/00075197-200303000-00013
Niu, Y. C., Feng, R. N., Hou, Y., Li, K., Kang, Z., Wang, J., Sun, C. H., & Li, Y. (2012). Histidine and arginine are associated with inflammation and oxidative stress in obese women. The British journal of nutrition, 108(1), 57–61. DOI: 10.1017/S0007114511005289
See more
Towheed, T. E., Maxwell, L., Anastassiades, T. P., Shea, B., Houpt, J., Robinson, V., Hochberg, M. C., & Wells, G. (2005). Glucosamine therapy for treating osteoarthritis. The Cochrane database of systematic reviews, (2), CD002946. DOI: 10.1002/14651858.CD002946.pub2
Hochberg, M. C., Martel-Pelletier, J., Monfort, J., Möller, I., Castillo, J. R., Arden, N., Berenbaum, F., Blanco, F. J., Conaghan, P. G., Doménech, G., Henrotin, Y., Pap, T., Richette, P., Sawitzke, A., du Souich, P., Pelletier, J. P., & MOVES Investigation Group (2016). Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial... Annals of the rheumatic diseases, 75(1), 37–44. DOI: 10.1136/annrheumdis-2014-206792
Richy, F., Bruyere, O., Ethgen, O., Cucherat, M., Henrotin, Y., & Reginster, J. Y. (2003). Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of internal medicine, 163(13), 1514–1522. DOI: 10.1001/archinte.163.13.1514
Kumar, S., Sugihara, F., Suzuki, K., Inoue, N., & Venkateswarathirukumara, S. (2015). A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. Journal of the science of food and agriculture, 95(4), 702–707. DOI: 10.1002/jsfa.6752
Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., Hafler, D. A., & Weiner, H. L. (1993). Effects of oral administration of type II collagen on rheumatoid arthritis. Science (New York, N.Y.), 261(5129), 1727–1730. DOI: 10.1126/science.8378772
Jordan, H. A., Levitz, L. S., Utgoff, K. L., & Lee, H. L. (1981). Role of food characteristics in behavioral change and weight loss. Journal of the American Dietetic Association, 79(1), 24–29. PMID: 7240603
Rubio, I. G., Castro, G., Zanini, A. C., & Medeiros-Neto, G. (2008). Oral ingestion of a hydrolyzed gelatin meal in subjects with normal weight and in obese patients: Postprandial effect on circulating gut peptides, glucose and insulin. Eating and weight disorders : EWD, 13(1), 48–53. DOI: 10.1007/BF03327784
Hochstenbach-Waelen, A., Westerterp-Plantenga, M. S., Veldhorst, M. A., & Westerterp, K. R. (2009). Single-protein casein and gelatin diets affect energy expenditure similarly but substrate balance and appetite differently in adults. The Journal of nutrition, 139(12), 2285–2292. DOI: 10.3945/jn.109.110403
Zdzieblik, D., Oesser, S., Baumstark, M. W., Gollhofer, A., & König, D. (2015). Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. The British journal of nutrition, 114(8), 1237–1245. DOI: 10.1017/S0007114515002810
Yamadera, Wataru & INAGAWA, Kentaro & Chiba, Shintaro & Bannai, Makoto & Takahashi, Michio & NAKAYAMA, Kazuhiko. (2007). Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms. 5. 126 - 131. DOI: 10.1111/j.1479-8425.2007.00262.x
Kawai N, Sakai N, Okuro M, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015;40(6):1405-1416. doi: 10.1038/npp.2014.326
Bannai M, Kawai N, Ono K, Nakahara K, Murakami N. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Front Neurol. 2012;3:61. Published 2012 Apr 18. doi: 10.3389/fneur.2012.00061
Vitamin A
Green AS, Fascetti AJ. Meeting the Vitamin A Requirement: The Efficacy and Importance of β-Carotene in Animal Species. ScientificWorldJournal. 2016;2016:7393620. doi: 10.1155/2016/7393620
Marjorie J Haskell, The challenge to reach nutritional adequacy for vitamin A: β-carotene bioavailability and conversion—evidence in humans, The American Journal of Clinical Nutrition, Volume 96, Issue 5, November 2012, Pages 1193S–1203S, DOI: 10.3945/ajcn.112.034850
De Pee, S., & Bloem, M. W. (2007). The bioavailability of (pro) vitamin A carotenoids and maximizing the contribution of homestead food production to combating vitamin A deficiency. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 77(3), 182–192. DOI: 10.1024/0300-9831.77.3.182
De Pee, S., & West, C. E. (1996). Dietary carotenoids and their role in combating vitamin A deficiency: a review of the literature. European journal of clinical nutrition, 50 Suppl 3, S38–S53. PMID: 8841773
Van Loo-Bouwman, C. A., West, C. E., van Breemen, R. B., Zhu, D., Siebelink, E., Versloot, P., Hulshof, P. J., van Lieshout, M., Russel, F. G., Schaafsma, G., & Naber, T. H. (2009). Vitamin A equivalency of beta-carotene in healthy adults: limitation of the extrinsic dual-isotope dilution technique to measure matrix effect. The British journal of nutrition, 101(12), 1837–1845. DOI: 10.1017/S0007114508131762
Vitamin B12
Lin, C. Y., Kuo, C. S., Lu, C. L., Wu, M. Y., & Huang, R. F. (2010). Elevated serum vitamin B(12) levels in association with tumor markers as the prognostic factors predictive for poor survival in patients with hepatocellular carcinoma. Nutrition and cancer, 62(2), 190–197. DOI: 10.1080/01635580903305334
Majaj A. S. (1966). Vitamin E-responsive macrocytic anemia in protein-calorie malnutrition. Measurements of vitamin E, folic acid, vitamin C, vitamin B12 and iron. The American journal of clinical nutrition, 18(5), 362–368. DOI: 10.1093/ajcn/18.5.362
Kwok, T., Tang, C., Woo, J., Lai, W. K., Law, L. K., & Pang, C. P. (1998). Randomized trial of the effect of supplementation on the cognitive function of older people with subnormal cobalamin levels. International journal of geriatric psychiatry, 13(9), 611–616. DOI: 10.1002/(sici)1099-1166(199809)13:9<611::aid-gps832>3.0.co;2-o
Lonn, E., Yusuf, S., Arnold, M. J., Sheridan, P., Pogue, J., Micks, M., McQueen, M. J., Probstfield, J., Fodor, G., Held, C., Genest, J., Jr, & Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators (2006). Homocysteine lowering with folic acid and B vitamins in vascular disease. The New England journal of medicine, 354(15), 1567–1577. DOI: 10.1056/NEJMoa060900
Kwok, T., Lee, J., Law, C. B., Pan, P. C., Yung, C. Y., Choi, K. C., & Lam, L. C. (2011). A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people. Clinical nutrition (Edinburgh, Scotland), 30(3), 297–302. DOI: 10.1016/j.clnu.2010.12.004
Clarke R. (2000). Lowering blood homocysteine with folic acid-based supplements: meta-analysis of randomised trials. Indian heart journal, 52(7 Suppl), S59–S64. PMID: 11339443
Ma, E., Iwasaki, M., Kobayashi, M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., & Tsugane, S. (2009). Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Nutrition and cancer, 61(4), 447–456. DOI: 10.1080/01635580802610123
Malouf, R., & Areosa Sastre, A. (2003). Vitamin B12 for cognition. The Cochrane database of systematic reviews, (3), CD004326. DOI: 10.1002/14651858.CD004326
Malouf, R., & Grimley Evans, J. (2008). Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. The Cochrane database of systematic reviews, (4), CD004514. DOI: 10.1002/14651858.CD004514.pub2
McNulty, H., Pentieva, K., Hoey, L., & Ward, M. (2008). Homocysteine, B-vitamins and CVD. The Proceedings of the Nutrition Society, 67(2), 232–237. DOI: 10.1017/S0029665108007076
Chen, K. J., Pan, W. H., Yang, F. L., Wei, I. L., Shaw, N. S., & Lin, B. F. (2005). Association of B vitamins status and homocysteine levels in elderly Taiwanese. Asia Pacific journal of clinical nutrition, 14(3), 250–255. PMID: 16169836
Iron
Lieu, P. T., Heiskala, M., Peterson, P. A., & Yang, Y. (2001). The roles of iron in health and disease. Molecular aspects of medicine, 22(1-2), 1–87. DOI: 10.1016/s0098-2997(00)00006-6
Abbaspour, N., Hurrell, R., & Kelishadi, R. (2014). Review on iron and its importance for human health. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 19(2), 164–174. PMCID: PMC3999603
Toxqui, L., De Piero, A., Courtois, V., Bastida, S., Sánchez-Muniz, F. J., & Vaquero, M. P. (2010). Deficiencia y sobrecarga de hierro: implicaciones en el estado oxidativo y la salud cardiovascular [Iron deficiency and overload. Implications in oxidative stress and cardiovascular health]. Nutricion hospitalaria, 25(3), 350–365. PMID: 20593115
Macdougall IC. Intravenous iron therapy in patients with chronic kidney disease: recent evidence and future directions. Clin Kidney J. 2017;10(Suppl 1):i16-i24. doi: 10.1093/ckj/sfx043
Chung M, Moorthy D, Hadar N, et al. Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Oct. (Comparative Effectiveness Reviews, No. 83.)
Berns J. S. (2017). Interpretation of the Kidney Disease: Improving Global Outcomes guidelines for iron therapy: commentary and emerging evidence. Clinical kidney journal, 10(Suppl 1), i3–i8. DOI: 10.1093/ckj/sfx042
Rubeor A, Goojha C, Manning J, White J. Does Iron Supplementation Improve Performance in Iron-Deficient Nonanemic Athletes?. Sports Health. 2018;10(5):400-405. doi: 10.1177/1941738118777488
Conjugated Linoleic Acid (CLA)
Moya-Camarena, S. Y., Vanden Heuvel, J. P., Blanchard, S. G., Leesnitzer, L. A., & Belury, M. A. (1999). Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. Journal of lipid research, 40(8), 1426–1433. PMID: 10428978
Rainer, L., & Heiss, C. J. (2004). Conjugated linoleic acid: health implications and effects on body composition. Journal of the American Dietetic Association, 104(6), 963–1032. DOI: 10.1016/j.jada.2004.03.016
Fischer-Posovszky, P., Kukulus, V., & Wabitsch, M. (2008). Konjugierte Linolsäuren (CLA) und ihre Bedeutung für die Reduktion des Körperfetts. Eine kritische Betrachtung der momentanen Datenlage [Conjugated linoleic acids (CLA) and their relevance in the reduction of body fat. A critical review of the currently available data]. MMW Fortschritte der Medizin, 149 Suppl 4, 128–131. PMID: 18402234
Banni S. (2002). Conjugated linoleic acid metabolism. Current opinion in lipidology, 13(3), 261–266. DOI: 10.1097/00041433-200206000-00005
Fritsche, J. and Steinhart, H. (1998), Analysis, occurrence, and physiological properties of trans fatty acids (TFA) with particular emphasis on conjugated linoleic acid isomers (CLA) – a review. Fett/Lipid, 100: 190-210. doi:10.1002/(SICI)1521-4133(199806)100:6<190::AID-LIPI190>3.0.CO;2-5
Gebauer, S. K., Chardigny, J. M., Jakobsen, M. U., Lamarche, B., Lock, A. L., Proctor, S. D., & Baer, D. J. (2011). Effects of ruminant trans fatty acids on cardiovascular disease and cancer: a comprehensive review of epidemiological, clinical, and mechanistic studies. Advances in nutrition (Bethesda, Md.), 2(4), 332–354. DOI: 10.3945/an.111.000521
Mozaffarian, D., Aro, A., & Willett, W. C. (2009). Health effects of trans-fatty acids: experimental and observational evidence. European journal of clinical nutrition, 63 Suppl 2, S5–S21. DOI: 10.1038/sj.ejcn.1602973
Bendsen, N. T., Christensen, R., Bartels, E. M., & Astrup, A. (2011). Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies. European journal of clinical nutrition, 65(7), 773–783. DOI: 10.1038/ejcn.2011.34
Dhiman, T. R., Nam, S. H., & Ure, A. L. (2005). Factors affecting conjugated linoleic acid content in milk and meat. Critical reviews in food science and nutrition, 45(6), 463–482. DOI: 10.1080/10408390591034463
Dhiman, T. R., Anand, G. R., Satter, L. D., & Pariza, M. W. (1999). Conjugated linoleic acid content of milk from cows fed different diets. Journal of dairy science, 82(10), 2146–2156. DOI: 10.3168/jds.S0022-0302(99)75458-5
Ritzenthaler, K. L., McGuire, M. K., Falen, R., Shultz, T. D., Dasgupta, N., & McGuire, M. A. (2001). Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. The Journal of nutrition, 131(5), 1548–1554. DOI: 10.1093/jn/131.5.1548
Kramer, J. K., Cruz-Hernandez, C., Deng, Z., Zhou, J., Jahreis, G., & Dugan, M. E. (2004). Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal products. The American journal of clinical nutrition, 79(6 Suppl), 1137S–1145S. DOI: 10.1093/ajcn/79.6.1137S
Bissonauth V, Chouinard Y, Marin J, et al. The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters. The Journal of Nutritional Biochemistry. 2006 Sep;17(9):597-603. DOI: 10.1016/j.jnutbio.2005.10.010
Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. Journal of Food Composition and Analysis : an Official Publication of the United Nations University, International Network of Food Data Systems. 1992 Sep;5(3):185-197. DOI: 10.1016/0889-1575(92)90037-k
Miner, J. L., Cederberg, C. A., Nielsen, M. K., Chen, X., & Baile, C. A. (2001). Conjugated linoleic acid (CLA), body fat, and apoptosis. Obesity research, 9(2), 129–134. DOI: 10.1038/oby.2001.16
Evans, M., Lin, X., Odle, J., & McIntosh, M. (2002). Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes. The Journal of nutrition, 132(3), 450–455. DOI: 10.1093/jn/132.3.450
Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., Wadstein, J., & Gudmundsen, O. (2000). Conjugated linoleic acid reduces body fat mass in overweight and obese humans. The Journal of nutrition, 130(12), 2943–2948. DOI: 10.1093/jn/130.12.2943
Chen, S. C., Lin, Y. H., Huang, H. P., Hsu, W. L., Houng, J. Y., & Huang, C. K. (2012). Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population. Nutrition (Burbank, Los Angeles County, Calif.), 28(5), 559–565. DOI: 10.1016/j.nut.2011.09.008
Watras, A. C., Buchholz, A. C., Close, R. N., Zhang, Z., & Schoeller, D. A. (2007). The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain. International journal of obesity (2005), 31(3), 481–487. DOI: 10.1038/sj.ijo.0803437
Whigham, L. D., Watras, A. C., & Schoeller, D. A. (2007). Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. The American journal of clinical nutrition, 85(5), 1203–1211. DOI: 10.1093/ajcn/85.5.1203
Biotin
Glynis A. A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2012;5(11):28-34. PMID: 23198010
Janos Zempleni, Yousef I Hassan & Subhashinee SK Wijeratne (2008) Biotin and biotinidase deficiency, Expert Review of Endocrinology & Metabolism, 3:6, 715-724, DOI: 10.1586/17446651.3.6.715
Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166‐169. doi: 10.1159/000462981
Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166‐169. doi: 10.1159/000462981
S. Daniells and G. Hardy, “Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame?” Current Opinion in Clinical Nutrition & Metabolic Care, vol. 13, no. 6, pp. 690–697, November 2010. doi: 10.1097/MCO.0b013e32833ece02
Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008;3(6):715‐724. doi: 10.1586/17446651.3.6.715
2008;3(6):715‐724. doi: 10.1586/17446651.3.6.715
Sparavigna A, Tenconi B, La Penna L. Efficacy and tolerability of a biomineral formulation for treatment of onychoschizia: a randomized trial. Clin Cosmet Investig Dermatol. 2019;12:355‐362. Published 2019 May 13. doi: 10.2147/CCID.S187305
Lipner, S. R., & Scher, R. K. (2018). Biotin for the treatment of nail disease: what is the evidence?. The Journal of dermatological treatment, 29(4), 411–414. DOI: 10.1080/09546634.2017.1395799
Victor E. Colombo, Françoise Gerber, Max Bronhofer, George L. Floersheim. Treatment of brittle fingernails and onychoschizia with biotin: Scanning electron microscopy. Colombo, Victor E. et al. Journal of the American Academy of Dermatology, Volume 23, Issue 6, 1127 – 1132. DOI: https://doi.org/10.1016/0190-9622(90)70345-I
Trüeb RM. Serum Biotin Levels in Women Complaining of Hair Loss. Int J Trichology. 2016;8(2):73-77. doi: 10.4103/0974-7753.188040
Floersheim G. L. (1989). Behandlung brüchiger Fingernägel mit Biotin [Treatment of brittle fingernails with biotin]. Zeitschrift fur Hautkrankheiten, 64(1), 41–48. PMID: 2648686
Hochman, L. G., Scher, R. K., & Meyerson, M. S. (1993). Brittle nails: response to daily biotin supplementation. Cutis, 51(4), 303–305. PMID: 8477615
Scheinfeld, N., Dahdah, M. J., & Scher, R. (2007). Vitamins and minerals: their role in nail health and disease. Journal of drugs in dermatology : JDD, 6(8), 782–787. PMID: 17763607
Supplement Facts
Ingredients
Suggested Use
References
Product Details
- 3,000 mg of grass-fed bone per serving
- Made from grass-fed, grass-finished, pasture-raised beef from Argentina
- Freeze dried, non-defatted, and desiccated
- Bone Matrix, cartilage & raw whole bone marrow
- Whole bone extracts can contain a source of specialized cells, collagen, growth factors, fat-soluble activators, trace minerals, and glycosaminoglycans*
- Non-GMO
- Gluten and hormones free
- Free of binders or flow agents
- 1-month supply
- Easy-to-use capsules
- Manufactured in the USA in a cGMP-certified facility
- Third-party tested
Featured Ingredients
Vitamin A
A fat-soluble vitamin
Vitamin B12
water-soluble vitamin known as cobalamin
Iron
An important mineral
Conjugated Linoleic Acid (CLA)
A fatty acid found in meat
Biotin
Known as vitamin B7 or H
Superfood
Grass-fed Argentinian beef bone marrow supplement is made with bovine bone marrow, bone matrix, and cartilage to provide nutrients and vitamins found in the bone.*
Suggested use
Adults take 6 capsules daily as directed by a healthcare professional with 8 ounces of water or your favorite beverage. May be taken with or without food.
See caution
CAUTION: Do not exceed recommended dose. Pregnant, nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Please use caution if you have allergies or sensitivities to any of the listed ingredients. Keep out of reach of children and pets. Do not use if safety seal is damaged or missing. Store in a cool dry place. Use this product as a food supplement only. Do not use for weight reduction.
Additional Details
Superfood
Grass-fed Argentinian beef bone marrow supplement is made with bovine bone marrow, bone matrix, and cartilage to provide nutrients and vitamins found in the bone.*
See all ingredients
Ingredients:
Grass-Fed Bone Extract (Bovine; Bone Matrix, Marrow & Cartilage) (BSE-free). Other Ingredients: Methylcellulose Capsule.
Pairs With
References
Adam, M., Musilova, J., Krabcova, M., Brettschneider, I., Pesakova, V., & Deyl, Z. (1980). Effect of cartilage bone marrow extract on the metabolism of collagen in osteoarthrotic cartilage. Pharmacology, 21(1), 53–58. DOI: 10.1159/000137415
Zhong, Z., Wheeler, M. D., Li, X., Froh, M., Schemmer, P., Yin, M., Bunzendaul, H., Bradford, B., & Lemasters, J. J. (2003). L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 6(2), 229–240. DOI: 10.1097/00075197-200303000-00013
Niu, Y. C., Feng, R. N., Hou, Y., Li, K., Kang, Z., Wang, J., Sun, C. H., & Li, Y. (2012). Histidine and arginine are associated with inflammation and oxidative stress in obese women. The British journal of nutrition, 108(1), 57–61. DOI: 10.1017/S0007114511005289
See more
Towheed, T. E., Maxwell, L., Anastassiades, T. P., Shea, B., Houpt, J., Robinson, V., Hochberg, M. C., & Wells, G. (2005). Glucosamine therapy for treating osteoarthritis. The Cochrane database of systematic reviews, (2), CD002946. DOI: 10.1002/14651858.CD002946.pub2
Hochberg, M. C., Martel-Pelletier, J., Monfort, J., Möller, I., Castillo, J. R., Arden, N., Berenbaum, F., Blanco, F. J., Conaghan, P. G., Doménech, G., Henrotin, Y., Pap, T., Richette, P., Sawitzke, A., du Souich, P., Pelletier, J. P., & MOVES Investigation Group (2016). Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial... Annals of the rheumatic diseases, 75(1), 37–44. DOI: 10.1136/annrheumdis-2014-206792
Richy, F., Bruyere, O., Ethgen, O., Cucherat, M., Henrotin, Y., & Reginster, J. Y. (2003). Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of internal medicine, 163(13), 1514–1522. DOI: 10.1001/archinte.163.13.1514
Kumar, S., Sugihara, F., Suzuki, K., Inoue, N., & Venkateswarathirukumara, S. (2015). A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. Journal of the science of food and agriculture, 95(4), 702–707. DOI: 10.1002/jsfa.6752
Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., Hafler, D. A., & Weiner, H. L. (1993). Effects of oral administration of type II collagen on rheumatoid arthritis. Science (New York, N.Y.), 261(5129), 1727–1730. DOI: 10.1126/science.8378772
Jordan, H. A., Levitz, L. S., Utgoff, K. L., & Lee, H. L. (1981). Role of food characteristics in behavioral change and weight loss. Journal of the American Dietetic Association, 79(1), 24–29. PMID: 7240603
Rubio, I. G., Castro, G., Zanini, A. C., & Medeiros-Neto, G. (2008). Oral ingestion of a hydrolyzed gelatin meal in subjects with normal weight and in obese patients: Postprandial effect on circulating gut peptides, glucose and insulin. Eating and weight disorders : EWD, 13(1), 48–53. DOI: 10.1007/BF03327784
Hochstenbach-Waelen, A., Westerterp-Plantenga, M. S., Veldhorst, M. A., & Westerterp, K. R. (2009). Single-protein casein and gelatin diets affect energy expenditure similarly but substrate balance and appetite differently in adults. The Journal of nutrition, 139(12), 2285–2292. DOI: 10.3945/jn.109.110403
Zdzieblik, D., Oesser, S., Baumstark, M. W., Gollhofer, A., & König, D. (2015). Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. The British journal of nutrition, 114(8), 1237–1245. DOI: 10.1017/S0007114515002810
Yamadera, Wataru & INAGAWA, Kentaro & Chiba, Shintaro & Bannai, Makoto & Takahashi, Michio & NAKAYAMA, Kazuhiko. (2007). Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms. 5. 126 - 131. DOI: 10.1111/j.1479-8425.2007.00262.x
Kawai N, Sakai N, Okuro M, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015;40(6):1405-1416. doi: 10.1038/npp.2014.326
Bannai M, Kawai N, Ono K, Nakahara K, Murakami N. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Front Neurol. 2012;3:61. Published 2012 Apr 18. doi: 10.3389/fneur.2012.00061
Vitamin A
Green AS, Fascetti AJ. Meeting the Vitamin A Requirement: The Efficacy and Importance of β-Carotene in Animal Species. ScientificWorldJournal. 2016;2016:7393620. doi: 10.1155/2016/7393620
Marjorie J Haskell, The challenge to reach nutritional adequacy for vitamin A: β-carotene bioavailability and conversion—evidence in humans, The American Journal of Clinical Nutrition, Volume 96, Issue 5, November 2012, Pages 1193S–1203S, DOI: 10.3945/ajcn.112.034850
De Pee, S., & Bloem, M. W. (2007). The bioavailability of (pro) vitamin A carotenoids and maximizing the contribution of homestead food production to combating vitamin A deficiency. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 77(3), 182–192. DOI: 10.1024/0300-9831.77.3.182
De Pee, S., & West, C. E. (1996). Dietary carotenoids and their role in combating vitamin A deficiency: a review of the literature. European journal of clinical nutrition, 50 Suppl 3, S38–S53. PMID: 8841773
Van Loo-Bouwman, C. A., West, C. E., van Breemen, R. B., Zhu, D., Siebelink, E., Versloot, P., Hulshof, P. J., van Lieshout, M., Russel, F. G., Schaafsma, G., & Naber, T. H. (2009). Vitamin A equivalency of beta-carotene in healthy adults: limitation of the extrinsic dual-isotope dilution technique to measure matrix effect. The British journal of nutrition, 101(12), 1837–1845. DOI: 10.1017/S0007114508131762
Vitamin B12
Lin, C. Y., Kuo, C. S., Lu, C. L., Wu, M. Y., & Huang, R. F. (2010). Elevated serum vitamin B(12) levels in association with tumor markers as the prognostic factors predictive for poor survival in patients with hepatocellular carcinoma. Nutrition and cancer, 62(2), 190–197. DOI: 10.1080/01635580903305334
Majaj A. S. (1966). Vitamin E-responsive macrocytic anemia in protein-calorie malnutrition. Measurements of vitamin E, folic acid, vitamin C, vitamin B12 and iron. The American journal of clinical nutrition, 18(5), 362–368. DOI: 10.1093/ajcn/18.5.362
Kwok, T., Tang, C., Woo, J., Lai, W. K., Law, L. K., & Pang, C. P. (1998). Randomized trial of the effect of supplementation on the cognitive function of older people with subnormal cobalamin levels. International journal of geriatric psychiatry, 13(9), 611–616. DOI: 10.1002/(sici)1099-1166(199809)13:9<611::aid-gps832>3.0.co;2-o
Lonn, E., Yusuf, S., Arnold, M. J., Sheridan, P., Pogue, J., Micks, M., McQueen, M. J., Probstfield, J., Fodor, G., Held, C., Genest, J., Jr, & Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators (2006). Homocysteine lowering with folic acid and B vitamins in vascular disease. The New England journal of medicine, 354(15), 1567–1577. DOI: 10.1056/NEJMoa060900
Kwok, T., Lee, J., Law, C. B., Pan, P. C., Yung, C. Y., Choi, K. C., & Lam, L. C. (2011). A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people. Clinical nutrition (Edinburgh, Scotland), 30(3), 297–302. DOI: 10.1016/j.clnu.2010.12.004
Clarke R. (2000). Lowering blood homocysteine with folic acid-based supplements: meta-analysis of randomised trials. Indian heart journal, 52(7 Suppl), S59–S64. PMID: 11339443
Ma, E., Iwasaki, M., Kobayashi, M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., & Tsugane, S. (2009). Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Nutrition and cancer, 61(4), 447–456. DOI: 10.1080/01635580802610123
Malouf, R., & Areosa Sastre, A. (2003). Vitamin B12 for cognition. The Cochrane database of systematic reviews, (3), CD004326. DOI: 10.1002/14651858.CD004326
Malouf, R., & Grimley Evans, J. (2008). Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. The Cochrane database of systematic reviews, (4), CD004514. DOI: 10.1002/14651858.CD004514.pub2
McNulty, H., Pentieva, K., Hoey, L., & Ward, M. (2008). Homocysteine, B-vitamins and CVD. The Proceedings of the Nutrition Society, 67(2), 232–237. DOI: 10.1017/S0029665108007076
Chen, K. J., Pan, W. H., Yang, F. L., Wei, I. L., Shaw, N. S., & Lin, B. F. (2005). Association of B vitamins status and homocysteine levels in elderly Taiwanese. Asia Pacific journal of clinical nutrition, 14(3), 250–255. PMID: 16169836
Iron
Lieu, P. T., Heiskala, M., Peterson, P. A., & Yang, Y. (2001). The roles of iron in health and disease. Molecular aspects of medicine, 22(1-2), 1–87. DOI: 10.1016/s0098-2997(00)00006-6
Abbaspour, N., Hurrell, R., & Kelishadi, R. (2014). Review on iron and its importance for human health. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 19(2), 164–174. PMCID: PMC3999603
Toxqui, L., De Piero, A., Courtois, V., Bastida, S., Sánchez-Muniz, F. J., & Vaquero, M. P. (2010). Deficiencia y sobrecarga de hierro: implicaciones en el estado oxidativo y la salud cardiovascular [Iron deficiency and overload. Implications in oxidative stress and cardiovascular health]. Nutricion hospitalaria, 25(3), 350–365. PMID: 20593115
Macdougall IC. Intravenous iron therapy in patients with chronic kidney disease: recent evidence and future directions. Clin Kidney J. 2017;10(Suppl 1):i16-i24. doi: 10.1093/ckj/sfx043
Chung M, Moorthy D, Hadar N, et al. Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Oct. (Comparative Effectiveness Reviews, No. 83.)
Berns J. S. (2017). Interpretation of the Kidney Disease: Improving Global Outcomes guidelines for iron therapy: commentary and emerging evidence. Clinical kidney journal, 10(Suppl 1), i3–i8. DOI: 10.1093/ckj/sfx042
Rubeor A, Goojha C, Manning J, White J. Does Iron Supplementation Improve Performance in Iron-Deficient Nonanemic Athletes?. Sports Health. 2018;10(5):400-405. doi: 10.1177/1941738118777488
Conjugated Linoleic Acid (CLA)
Moya-Camarena, S. Y., Vanden Heuvel, J. P., Blanchard, S. G., Leesnitzer, L. A., & Belury, M. A. (1999). Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. Journal of lipid research, 40(8), 1426–1433. PMID: 10428978
Rainer, L., & Heiss, C. J. (2004). Conjugated linoleic acid: health implications and effects on body composition. Journal of the American Dietetic Association, 104(6), 963–1032. DOI: 10.1016/j.jada.2004.03.016
Fischer-Posovszky, P., Kukulus, V., & Wabitsch, M. (2008). Konjugierte Linolsäuren (CLA) und ihre Bedeutung für die Reduktion des Körperfetts. Eine kritische Betrachtung der momentanen Datenlage [Conjugated linoleic acids (CLA) and their relevance in the reduction of body fat. A critical review of the currently available data]. MMW Fortschritte der Medizin, 149 Suppl 4, 128–131. PMID: 18402234
Banni S. (2002). Conjugated linoleic acid metabolism. Current opinion in lipidology, 13(3), 261–266. DOI: 10.1097/00041433-200206000-00005
Fritsche, J. and Steinhart, H. (1998), Analysis, occurrence, and physiological properties of trans fatty acids (TFA) with particular emphasis on conjugated linoleic acid isomers (CLA) – a review. Fett/Lipid, 100: 190-210. doi:10.1002/(SICI)1521-4133(199806)100:6<190::AID-LIPI190>3.0.CO;2-5
Gebauer, S. K., Chardigny, J. M., Jakobsen, M. U., Lamarche, B., Lock, A. L., Proctor, S. D., & Baer, D. J. (2011). Effects of ruminant trans fatty acids on cardiovascular disease and cancer: a comprehensive review of epidemiological, clinical, and mechanistic studies. Advances in nutrition (Bethesda, Md.), 2(4), 332–354. DOI: 10.3945/an.111.000521
Mozaffarian, D., Aro, A., & Willett, W. C. (2009). Health effects of trans-fatty acids: experimental and observational evidence. European journal of clinical nutrition, 63 Suppl 2, S5–S21. DOI: 10.1038/sj.ejcn.1602973
Bendsen, N. T., Christensen, R., Bartels, E. M., & Astrup, A. (2011). Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies. European journal of clinical nutrition, 65(7), 773–783. DOI: 10.1038/ejcn.2011.34
Dhiman, T. R., Nam, S. H., & Ure, A. L. (2005). Factors affecting conjugated linoleic acid content in milk and meat. Critical reviews in food science and nutrition, 45(6), 463–482. DOI: 10.1080/10408390591034463
Dhiman, T. R., Anand, G. R., Satter, L. D., & Pariza, M. W. (1999). Conjugated linoleic acid content of milk from cows fed different diets. Journal of dairy science, 82(10), 2146–2156. DOI: 10.3168/jds.S0022-0302(99)75458-5
Ritzenthaler, K. L., McGuire, M. K., Falen, R., Shultz, T. D., Dasgupta, N., & McGuire, M. A. (2001). Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. The Journal of nutrition, 131(5), 1548–1554. DOI: 10.1093/jn/131.5.1548
Kramer, J. K., Cruz-Hernandez, C., Deng, Z., Zhou, J., Jahreis, G., & Dugan, M. E. (2004). Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal products. The American journal of clinical nutrition, 79(6 Suppl), 1137S–1145S. DOI: 10.1093/ajcn/79.6.1137S
Bissonauth V, Chouinard Y, Marin J, et al. The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters. The Journal of Nutritional Biochemistry. 2006 Sep;17(9):597-603. DOI: 10.1016/j.jnutbio.2005.10.010
Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. Journal of Food Composition and Analysis : an Official Publication of the United Nations University, International Network of Food Data Systems. 1992 Sep;5(3):185-197. DOI: 10.1016/0889-1575(92)90037-k
Miner, J. L., Cederberg, C. A., Nielsen, M. K., Chen, X., & Baile, C. A. (2001). Conjugated linoleic acid (CLA), body fat, and apoptosis. Obesity research, 9(2), 129–134. DOI: 10.1038/oby.2001.16
Evans, M., Lin, X., Odle, J., & McIntosh, M. (2002). Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes. The Journal of nutrition, 132(3), 450–455. DOI: 10.1093/jn/132.3.450
Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., Wadstein, J., & Gudmundsen, O. (2000). Conjugated linoleic acid reduces body fat mass in overweight and obese humans. The Journal of nutrition, 130(12), 2943–2948. DOI: 10.1093/jn/130.12.2943
Chen, S. C., Lin, Y. H., Huang, H. P., Hsu, W. L., Houng, J. Y., & Huang, C. K. (2012). Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population. Nutrition (Burbank, Los Angeles County, Calif.), 28(5), 559–565. DOI: 10.1016/j.nut.2011.09.008
Watras, A. C., Buchholz, A. C., Close, R. N., Zhang, Z., & Schoeller, D. A. (2007). The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain. International journal of obesity (2005), 31(3), 481–487. DOI: 10.1038/sj.ijo.0803437
Whigham, L. D., Watras, A. C., & Schoeller, D. A. (2007). Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. The American journal of clinical nutrition, 85(5), 1203–1211. DOI: 10.1093/ajcn/85.5.1203
Biotin
Glynis A. A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2012;5(11):28-34. PMID: 23198010
Janos Zempleni, Yousef I Hassan & Subhashinee SK Wijeratne (2008) Biotin and biotinidase deficiency, Expert Review of Endocrinology & Metabolism, 3:6, 715-724, DOI: 10.1586/17446651.3.6.715
Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166‐169. doi: 10.1159/000462981
Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166‐169. doi: 10.1159/000462981
S. Daniells and G. Hardy, “Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame?” Current Opinion in Clinical Nutrition & Metabolic Care, vol. 13, no. 6, pp. 690–697, November 2010. doi: 10.1097/MCO.0b013e32833ece02
Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008;3(6):715‐724. doi: 10.1586/17446651.3.6.715
2008;3(6):715‐724. doi: 10.1586/17446651.3.6.715
Sparavigna A, Tenconi B, La Penna L. Efficacy and tolerability of a biomineral formulation for treatment of onychoschizia: a randomized trial. Clin Cosmet Investig Dermatol. 2019;12:355‐362. Published 2019 May 13. doi: 10.2147/CCID.S187305
Lipner, S. R., & Scher, R. K. (2018). Biotin for the treatment of nail disease: what is the evidence?. The Journal of dermatological treatment, 29(4), 411–414. DOI: 10.1080/09546634.2017.1395799
Victor E. Colombo, Françoise Gerber, Max Bronhofer, George L. Floersheim. Treatment of brittle fingernails and onychoschizia with biotin: Scanning electron microscopy. Colombo, Victor E. et al. Journal of the American Academy of Dermatology, Volume 23, Issue 6, 1127 – 1132. DOI: https://doi.org/10.1016/0190-9622(90)70345-I
Trüeb RM. Serum Biotin Levels in Women Complaining of Hair Loss. Int J Trichology. 2016;8(2):73-77. doi: 10.4103/0974-7753.188040
Floersheim G. L. (1989). Behandlung brüchiger Fingernägel mit Biotin [Treatment of brittle fingernails with biotin]. Zeitschrift fur Hautkrankheiten, 64(1), 41–48. PMID: 2648686
Hochman, L. G., Scher, R. K., & Meyerson, M. S. (1993). Brittle nails: response to daily biotin supplementation. Cutis, 51(4), 303–305. PMID: 8477615
Scheinfeld, N., Dahdah, M. J., & Scher, R. (2007). Vitamins and minerals: their role in nail health and disease. Journal of drugs in dermatology : JDD, 6(8), 782–787. PMID: 17763607
Grass-Fed Bone Extract (Bovine; Bone Matrix, Marrow & Cartilage) (BSE-free). Other Ingredients: Methylcellulose Capsule.
Adults take 6 capsules daily as directed by a healthcare professional with 8 ounces of water or your favorite beverage. May be taken with or without food.
CAUTION: Do not exceed recommended dose. Pregnant, nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Please use caution if you have allergies or sensitivities to any of the listed ingredients. Keep out of reach of children and pets. Do not use if safety seal is damaged or missing. Store in a cool dry place. Use this product as a food supplement only. Do not use for weight reduction.
Adam, M., Musilova, J., Krabcova, M., Brettschneider, I., Pesakova, V., & Deyl, Z. (1980). Effect of cartilage bone marrow extract on the metabolism of collagen in osteoarthrotic cartilage. Pharmacology, 21(1), 53–58. DOI: 10.1159/000137415
Zhong, Z., Wheeler, M. D., Li, X., Froh, M., Schemmer, P., Yin, M., Bunzendaul, H., Bradford, B., & Lemasters, J. J. (2003). L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 6(2), 229–240. DOI: 10.1097/00075197-200303000-00013
Niu, Y. C., Feng, R. N., Hou, Y., Li, K., Kang, Z., Wang, J., Sun, C. H., & Li, Y. (2012). Histidine and arginine are associated with inflammation and oxidative stress in obese women. The British journal of nutrition, 108(1), 57–61. DOI: 10.1017/S0007114511005289
Towheed, T. E., Maxwell, L., Anastassiades, T. P., Shea, B., Houpt, J., Robinson, V., Hochberg, M. C., & Wells, G. (2005). Glucosamine therapy for treating osteoarthritis. The Cochrane database of systematic reviews, (2), CD002946. DOI: 10.1002/14651858.CD002946.pub2
Hochberg, M. C., Martel-Pelletier, J., Monfort, J., Möller, I., Castillo, J. R., Arden, N., Berenbaum, F., Blanco, F. J., Conaghan, P. G., Doménech, G., Henrotin, Y., Pap, T., Richette, P., Sawitzke, A., du Souich, P., Pelletier, J. P., & MOVES Investigation Group (2016). Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial... Annals of the rheumatic diseases, 75(1), 37–44. DOI: 10.1136/annrheumdis-2014-206792
Richy, F., Bruyere, O., Ethgen, O., Cucherat, M., Henrotin, Y., & Reginster, J. Y. (2003). Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of internal medicine, 163(13), 1514–1522. DOI: 10.1001/archinte.163.13.1514
Kumar, S., Sugihara, F., Suzuki, K., Inoue, N., & Venkateswarathirukumara, S. (2015). A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. Journal of the science of food and agriculture, 95(4), 702–707. DOI: 10.1002/jsfa.6752
Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., Hafler, D. A., & Weiner, H. L. (1993). Effects of oral administration of type II collagen on rheumatoid arthritis. Science (New York, N.Y.), 261(5129), 1727–1730. DOI: 10.1126/science.8378772
Jordan, H. A., Levitz, L. S., Utgoff, K. L., & Lee, H. L. (1981). Role of food characteristics in behavioral change and weight loss. Journal of the American Dietetic Association, 79(1), 24–29. PMID: 7240603
Rubio, I. G., Castro, G., Zanini, A. C., & Medeiros-Neto, G. (2008). Oral ingestion of a hydrolyzed gelatin meal in subjects with normal weight and in obese patients: Postprandial effect on circulating gut peptides, glucose and insulin. Eating and weight disorders : EWD, 13(1), 48–53. DOI: 10.1007/BF03327784
Hochstenbach-Waelen, A., Westerterp-Plantenga, M. S., Veldhorst, M. A., & Westerterp, K. R. (2009). Single-protein casein and gelatin diets affect energy expenditure similarly but substrate balance and appetite differently in adults. The Journal of nutrition, 139(12), 2285–2292. DOI: 10.3945/jn.109.110403
Zdzieblik, D., Oesser, S., Baumstark, M. W., Gollhofer, A., & König, D. (2015). Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. The British journal of nutrition, 114(8), 1237–1245. DOI: 10.1017/S0007114515002810
Yamadera, Wataru & INAGAWA, Kentaro & Chiba, Shintaro & Bannai, Makoto & Takahashi, Michio & NAKAYAMA, Kazuhiko. (2007). Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms. 5. 126 - 131. DOI: 10.1111/j.1479-8425.2007.00262.x
Kawai N, Sakai N, Okuro M, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015;40(6):1405-1416. doi: 10.1038/npp.2014.326
Bannai M, Kawai N, Ono K, Nakahara K, Murakami N. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Front Neurol. 2012;3:61. Published 2012 Apr 18. doi: 10.3389/fneur.2012.00061
Vitamin A
Green AS, Fascetti AJ. Meeting the Vitamin A Requirement: The Efficacy and Importance of β-Carotene in Animal Species. ScientificWorldJournal. 2016;2016:7393620. doi: 10.1155/2016/7393620
Marjorie J Haskell, The challenge to reach nutritional adequacy for vitamin A: β-carotene bioavailability and conversion—evidence in humans, The American Journal of Clinical Nutrition, Volume 96, Issue 5, November 2012, Pages 1193S–1203S, DOI: 10.3945/ajcn.112.034850
De Pee, S., & Bloem, M. W. (2007). The bioavailability of (pro) vitamin A carotenoids and maximizing the contribution of homestead food production to combating vitamin A deficiency. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 77(3), 182–192. DOI: 10.1024/0300-9831.77.3.182
De Pee, S., & West, C. E. (1996). Dietary carotenoids and their role in combating vitamin A deficiency: a review of the literature. European journal of clinical nutrition, 50 Suppl 3, S38–S53. PMID: 8841773
Van Loo-Bouwman, C. A., West, C. E., van Breemen, R. B., Zhu, D., Siebelink, E., Versloot, P., Hulshof, P. J., van Lieshout, M., Russel, F. G., Schaafsma, G., & Naber, T. H. (2009). Vitamin A equivalency of beta-carotene in healthy adults: limitation of the extrinsic dual-isotope dilution technique to measure matrix effect. The British journal of nutrition, 101(12), 1837–1845. DOI: 10.1017/S0007114508131762
Vitamin B12
Lin, C. Y., Kuo, C. S., Lu, C. L., Wu, M. Y., & Huang, R. F. (2010). Elevated serum vitamin B(12) levels in association with tumor markers as the prognostic factors predictive for poor survival in patients with hepatocellular carcinoma. Nutrition and cancer, 62(2), 190–197. DOI: 10.1080/01635580903305334
Majaj A. S. (1966). Vitamin E-responsive macrocytic anemia in protein-calorie malnutrition. Measurements of vitamin E, folic acid, vitamin C, vitamin B12 and iron. The American journal of clinical nutrition, 18(5), 362–368. DOI: 10.1093/ajcn/18.5.362
Kwok, T., Tang, C., Woo, J., Lai, W. K., Law, L. K., & Pang, C. P. (1998). Randomized trial of the effect of supplementation on the cognitive function of older people with subnormal cobalamin levels. International journal of geriatric psychiatry, 13(9), 611–616. DOI: 10.1002/(sici)1099-1166(199809)13:9<611::aid-gps832>3.0.co;2-o
Lonn, E., Yusuf, S., Arnold, M. J., Sheridan, P., Pogue, J., Micks, M., McQueen, M. J., Probstfield, J., Fodor, G., Held, C., Genest, J., Jr, & Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators (2006). Homocysteine lowering with folic acid and B vitamins in vascular disease. The New England journal of medicine, 354(15), 1567–1577. DOI: 10.1056/NEJMoa060900
Kwok, T., Lee, J., Law, C. B., Pan, P. C., Yung, C. Y., Choi, K. C., & Lam, L. C. (2011). A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people. Clinical nutrition (Edinburgh, Scotland), 30(3), 297–302. DOI: 10.1016/j.clnu.2010.12.004
Clarke R. (2000). Lowering blood homocysteine with folic acid-based supplements: meta-analysis of randomised trials. Indian heart journal, 52(7 Suppl), S59–S64. PMID: 11339443
Ma, E., Iwasaki, M., Kobayashi, M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., & Tsugane, S. (2009). Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Nutrition and cancer, 61(4), 447–456. DOI: 10.1080/01635580802610123
Malouf, R., & Areosa Sastre, A. (2003). Vitamin B12 for cognition. The Cochrane database of systematic reviews, (3), CD004326. DOI: 10.1002/14651858.CD004326
Malouf, R., & Grimley Evans, J. (2008). Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. The Cochrane database of systematic reviews, (4), CD004514. DOI: 10.1002/14651858.CD004514.pub2
McNulty, H., Pentieva, K., Hoey, L., & Ward, M. (2008). Homocysteine, B-vitamins and CVD. The Proceedings of the Nutrition Society, 67(2), 232–237. DOI: 10.1017/S0029665108007076
Chen, K. J., Pan, W. H., Yang, F. L., Wei, I. L., Shaw, N. S., & Lin, B. F. (2005). Association of B vitamins status and homocysteine levels in elderly Taiwanese. Asia Pacific journal of clinical nutrition, 14(3), 250–255. PMID: 16169836
Iron
Lieu, P. T., Heiskala, M., Peterson, P. A., & Yang, Y. (2001). The roles of iron in health and disease. Molecular aspects of medicine, 22(1-2), 1–87. DOI: 10.1016/s0098-2997(00)00006-6
Abbaspour, N., Hurrell, R., & Kelishadi, R. (2014). Review on iron and its importance for human health. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 19(2), 164–174. PMCID: PMC3999603
Toxqui, L., De Piero, A., Courtois, V., Bastida, S., Sánchez-Muniz, F. J., & Vaquero, M. P. (2010). Deficiencia y sobrecarga de hierro: implicaciones en el estado oxidativo y la salud cardiovascular [Iron deficiency and overload. Implications in oxidative stress and cardiovascular health]. Nutricion hospitalaria, 25(3), 350–365. PMID: 20593115
Macdougall IC. Intravenous iron therapy in patients with chronic kidney disease: recent evidence and future directions. Clin Kidney J. 2017;10(Suppl 1):i16-i24. doi: 10.1093/ckj/sfx043
Chung M, Moorthy D, Hadar N, et al. Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Oct. (Comparative Effectiveness Reviews, No. 83.)
Berns J. S. (2017). Interpretation of the Kidney Disease: Improving Global Outcomes guidelines for iron therapy: commentary and emerging evidence. Clinical kidney journal, 10(Suppl 1), i3–i8. DOI: 10.1093/ckj/sfx042
Rubeor A, Goojha C, Manning J, White J. Does Iron Supplementation Improve Performance in Iron-Deficient Nonanemic Athletes?. Sports Health. 2018;10(5):400-405. doi: 10.1177/1941738118777488
Conjugated Linoleic Acid (CLA)
Moya-Camarena, S. Y., Vanden Heuvel, J. P., Blanchard, S. G., Leesnitzer, L. A., & Belury, M. A. (1999). Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. Journal of lipid research, 40(8), 1426–1433. PMID: 10428978
Rainer, L., & Heiss, C. J. (2004). Conjugated linoleic acid: health implications and effects on body composition. Journal of the American Dietetic Association, 104(6), 963–1032. DOI: 10.1016/j.jada.2004.03.016
Fischer-Posovszky, P., Kukulus, V., & Wabitsch, M. (2008). Konjugierte Linolsäuren (CLA) und ihre Bedeutung für die Reduktion des Körperfetts. Eine kritische Betrachtung der momentanen Datenlage [Conjugated linoleic acids (CLA) and their relevance in the reduction of body fat. A critical review of the currently available data]. MMW Fortschritte der Medizin, 149 Suppl 4, 128–131. PMID: 18402234
Banni S. (2002). Conjugated linoleic acid metabolism. Current opinion in lipidology, 13(3), 261–266. DOI: 10.1097/00041433-200206000-00005
Fritsche, J. and Steinhart, H. (1998), Analysis, occurrence, and physiological properties of trans fatty acids (TFA) with particular emphasis on conjugated linoleic acid isomers (CLA) – a review. Fett/Lipid, 100: 190-210. doi:10.1002/(SICI)1521-4133(199806)100:6<190::AID-LIPI190>3.0.CO;2-5
Gebauer, S. K., Chardigny, J. M., Jakobsen, M. U., Lamarche, B., Lock, A. L., Proctor, S. D., & Baer, D. J. (2011). Effects of ruminant trans fatty acids on cardiovascular disease and cancer: a comprehensive review of epidemiological, clinical, and mechanistic studies. Advances in nutrition (Bethesda, Md.), 2(4), 332–354. DOI: 10.3945/an.111.000521
Mozaffarian, D., Aro, A., & Willett, W. C. (2009). Health effects of trans-fatty acids: experimental and observational evidence. European journal of clinical nutrition, 63 Suppl 2, S5–S21. DOI: 10.1038/sj.ejcn.1602973
Bendsen, N. T., Christensen, R., Bartels, E. M., & Astrup, A. (2011). Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies. European journal of clinical nutrition, 65(7), 773–783. DOI: 10.1038/ejcn.2011.34
Dhiman, T. R., Nam, S. H., & Ure, A. L. (2005). Factors affecting conjugated linoleic acid content in milk and meat. Critical reviews in food science and nutrition, 45(6), 463–482. DOI: 10.1080/10408390591034463
Dhiman, T. R., Anand, G. R., Satter, L. D., & Pariza, M. W. (1999). Conjugated linoleic acid content of milk from cows fed different diets. Journal of dairy science, 82(10), 2146–2156. DOI: 10.3168/jds.S0022-0302(99)75458-5
Ritzenthaler, K. L., McGuire, M. K., Falen, R., Shultz, T. D., Dasgupta, N., & McGuire, M. A. (2001). Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. The Journal of nutrition, 131(5), 1548–1554. DOI: 10.1093/jn/131.5.1548
Kramer, J. K., Cruz-Hernandez, C., Deng, Z., Zhou, J., Jahreis, G., & Dugan, M. E. (2004). Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal products. The American journal of clinical nutrition, 79(6 Suppl), 1137S–1145S. DOI: 10.1093/ajcn/79.6.1137S
Bissonauth V, Chouinard Y, Marin J, et al. The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters. The Journal of Nutritional Biochemistry. 2006 Sep;17(9):597-603. DOI: 10.1016/j.jnutbio.2005.10.010
Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. Journal of Food Composition and Analysis : an Official Publication of the United Nations University, International Network of Food Data Systems. 1992 Sep;5(3):185-197. DOI: 10.1016/0889-1575(92)90037-k
Miner, J. L., Cederberg, C. A., Nielsen, M. K., Chen, X., & Baile, C. A. (2001). Conjugated linoleic acid (CLA), body fat, and apoptosis. Obesity research, 9(2), 129–134. DOI: 10.1038/oby.2001.16
Evans, M., Lin, X., Odle, J., & McIntosh, M. (2002). Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes. The Journal of nutrition, 132(3), 450–455. DOI: 10.1093/jn/132.3.450
Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., Wadstein, J., & Gudmundsen, O. (2000). Conjugated linoleic acid reduces body fat mass in overweight and obese humans. The Journal of nutrition, 130(12), 2943–2948. DOI: 10.1093/jn/130.12.2943
Chen, S. C., Lin, Y. H., Huang, H. P., Hsu, W. L., Houng, J. Y., & Huang, C. K. (2012). Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population. Nutrition (Burbank, Los Angeles County, Calif.), 28(5), 559–565. DOI: 10.1016/j.nut.2011.09.008
Watras, A. C., Buchholz, A. C., Close, R. N., Zhang, Z., & Schoeller, D. A. (2007). The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain. International journal of obesity (2005), 31(3), 481–487. DOI: 10.1038/sj.ijo.0803437
Whigham, L. D., Watras, A. C., & Schoeller, D. A. (2007). Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. The American journal of clinical nutrition, 85(5), 1203–1211. DOI: 10.1093/ajcn/85.5.1203
Biotin
Glynis A. A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2012;5(11):28-34. PMID: 23198010
Janos Zempleni, Yousef I Hassan & Subhashinee SK Wijeratne (2008) Biotin and biotinidase deficiency, Expert Review of Endocrinology & Metabolism, 3:6, 715-724, DOI: 10.1586/17446651.3.6.715
Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166‐169. doi: 10.1159/000462981
Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017;3(3):166‐169. doi: 10.1159/000462981
S. Daniells and G. Hardy, “Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame?” Current Opinion in Clinical Nutrition & Metabolic Care, vol. 13, no. 6, pp. 690–697, November 2010. doi: 10.1097/MCO.0b013e32833ece02
Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008;3(6):715‐724. doi: 10.1586/17446651.3.6.715
2008;3(6):715‐724. doi: 10.1586/17446651.3.6.715
Sparavigna A, Tenconi B, La Penna L. Efficacy and tolerability of a biomineral formulation for treatment of onychoschizia: a randomized trial. Clin Cosmet Investig Dermatol. 2019;12:355‐362. Published 2019 May 13. doi: 10.2147/CCID.S187305
Lipner, S. R., & Scher, R. K. (2018). Biotin for the treatment of nail disease: what is the evidence?. The Journal of dermatological treatment, 29(4), 411–414. DOI: 10.1080/09546634.2017.1395799
Victor E. Colombo, Françoise Gerber, Max Bronhofer, George L. Floersheim. Treatment of brittle fingernails and onychoschizia with biotin: Scanning electron microscopy. Colombo, Victor E. et al. Journal of the American Academy of Dermatology, Volume 23, Issue 6, 1127 – 1132. DOI: https://doi.org/10.1016/0190-9622(90)70345-I
Trüeb RM. Serum Biotin Levels in Women Complaining of Hair Loss. Int J Trichology. 2016;8(2):73-77. doi: 10.4103/0974-7753.188040
Floersheim G. L. (1989). Behandlung brüchiger Fingernägel mit Biotin [Treatment of brittle fingernails with biotin]. Zeitschrift fur Hautkrankheiten, 64(1), 41–48. PMID: 2648686
Hochman, L. G., Scher, R. K., & Meyerson, M. S. (1993). Brittle nails: response to daily biotin supplementation. Cutis, 51(4), 303–305. PMID: 8477615
Scheinfeld, N., Dahdah, M. J., & Scher, R. (2007). Vitamins and minerals: their role in nail health and disease. Journal of drugs in dermatology : JDD, 6(8), 782–787. PMID: 17763607
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FL
11/18/2022
Fernando L.
United States
FV
09/15/2022
Francille V.
United States
BT
08/21/2022
Brandie T.
United States
FV
08/10/2022
Francille V.
United StatesGood
Have only used for a few weeks so not sure of long term effects. So far it has been good
JJ
06/01/2022
Judy J.
United StatesGrass Fed Bone Morrow
I haven't been taking it long enough to feel a difference. However, I've also been taking Codeage Grass Fed Beef Liver and I've noticed a difference in my energy level. Not sure what I'm supposed to feel with the Bone Marrow, but I'm hoping it will make my bones stronger.